Early Auburn vs. Oklahoma Prediction & Odds: Week 4 College Football Picks
Last Updated: September 18, 2025 6:35 PM EDT β’ 4 minute read X Social Google News Link
My early Auburn vs. Oklahoma prediction sees Tigers head coach Hugh Freeze remaining firmly on the hot seat after this top-25 showdown at Memorial Stadium in Norman, Okla.
As we continue our college football predictions for Week 4, the Sooners enter as 6.5-point betting favorites behind Heisman hopeful John Mateer, who looks to add another marquee win to his resume.
With momentum building and the home crowd behind them, my college football picks are siding with the Sooners to handle business when the teams kick off Saturday at 3:30 p.m. ET (ABC).
π° Early Auburn vs. Oklahoma prediction & best bet
Stay ahead with the rest of our early college football predictions.
π ΎοΈ Oklahoma -6.5 (-110) ββββ
Both Freeze and Brent Venables are leaning on transfer QBs to save their jobs, and both have gotten off to a strong enough start thus far with Auburn and Oklahoma both ranked in the top 25. But Venables has the upper hand in this game, as the defensive guru has a deep familiarity with the Tigers' man behind center.
Last season, Arnold was in and out of the lineup as the Sooners' QB1 as the former blue-chip recruit struggled to find his form. So while his hot start for Auburn has given the fans hope on the Plains, his play should be taken with a grain of salt. He put up a 47.8 QBR for Oklahoma last season, and his passing has been sporadic for Auburn this year against three teams that rank outside the top 70 in SP+ on defense. The Sooners rank No. 5 in SP+ and No. 1 in EPA per pass on defense.
With the likes of Peyton Bowen, Kendal Daniels, and Courtland Guillory poised to make Arnold's day difficult, Heisman Trophy odds favorite John Mateer should be able to score enough to cover. The Sooners are No. 21 in SP+ on offense thanks to Mateer and offensive coordinator Ben Arbuckle.
In a game that I expect to be more about the defenses than the transfer QBs, the Sooners have the clear advantage. And if Venables' team can win by at least a touchdown at home, a $10 bet pays a $9.09 profit.
π Auburn vs. Oklahoma odds: Week 4
College football odds update live in real time.
π Auburn vs. Oklahoma opening odds
- Moneyline: Auburn +175 | Oklahoma -208
- Spread: Auburn +4.5 (-110) | Oklahoma -4.5 (-110)
- Over/Under: Over 49.5 (-110) | Under 49.5 (-110)
π Auburn vs. Oklahoma odds analysis
With home-field advantage in Norman, the Sooners opened as a definitive favorite at -4.5, and Oklahoma has only seen the line shift further in its direction. The Sooners are now a 6.5-point betting favorite at our best college football betting sites, and the public is all over Venables' team against Freeze's, with 68% of bettors are backing Oklahoma to cover at home.
Given how strongly the public is backing Oklahoma, this line could shift another full point in the Sooners' direction by Saturday afternoon.
π Auburn vs. Oklahoma odds update
Oklahoma remains a 6.5-point home favorite, though the odds are shifting further in the Sooners' favor, currently at -115 as of Wednesday morning. Meanwhile, the total is now at 47.5 or 47 points at most major sportsbooks.
π Auburn vs. Oklahoma injury report
| Auburn | Oklahoma |
|---|---|
| Damari Alston, RB (questionable) | Michael Fasusi, OL (questionable) |
| Durell Robinson, RB (questionable) |
πΊ Auburn vs. Oklahoma game info
- When: Saturday, Sept. 20
- Kickoff: 3:30 p.m. ET
- Where: Memorial Stadium (Norman, Okla.)
- How to watch: ABC
β Auburn vs. Oklahoma FAQs
Who is favored to win Auburn vs. Oklahoma?
Oklahoma is a -225 moneyline favorite at home against Auburn, implying a 69.23% probability the Sooners will win. Auburn is a +200 moneyline favorite on the road against Oklahoma, implying a 33.33% probability the Tigers will win.
What are the opening odds for Auburn vs. Oklahoma?
Oklahoma opened as a 4.5-point betting favorite, with the Sooners now -6.5 against Auburn. The game total sits between 48 and 48.5.
How do college football odds work?
When betting on college football odds, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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Rob Paul X social