Colorado vs. Houston Prediction, Odds & Picks: College Football Week 3 Best Bets

Last Updated: September 11, 2025 11:07 AM EDT • 5 minute read X Social Google News Link

Houston is a 4.5-point betting favorite, and my Colorado vs. Houston prediction is backing the Cougars to cover for Friday’s 7:30 p.m. ET (ESPN) game at TDECU Stadium in Houston. The Cougars have outscored their opponents 62-9 through two games, but are they one of the best college football picks this week?
Despite, the Buffaloes bouncing back from a Week 1 loss, defeating Delaware 31-7, I don't trust Deion Sanders' team to win again with my college football predictions for Week 3.
🏈 Colorado vs. Houston prediction
College football expert picks for Thursday; odds subject to change.
- Moneyline pick: Houston (-196 via Caesars) ⭐⭐⭐⭐
- Against the spread pick: Houston -4.5 (-105 via Caesars) ⭐⭐⭐⭐
- Over/Under pick: Over 45 (-110 via bet365) ⭐⭐⭐
- Best bet: Conner Weigman Over 191.5 passing yards (-111 via Caesars) ⭐⭐⭐⭐⭐
📝 Colorado vs. Houston best bet
Track the latest college football scores for line movement and matchup info.
🐾 Houston -4.5 (-110) ⭐⭐⭐⭐⭐
The Cougars have dominated their first two games, but considering their opponents, it’s hard to know exactly what this team will look like against better competition. Meanwhile, the Buffaloes lost 27-20 to Georgia Tech in Week 1 and were outgained 463 to 305. And while they won by 24 in Week 2, the Buffaloes only outgained Delaware by two yards.
Colorado has forced three turnovers in each game, which has been a key reason for their success. But Conner Weigman only has seven interceptions in 17 career games, and the Cougars haven’t turned the ball over this season.
The Buffaloes can’t win without turnovers, and Weigman is experienced enough to avoid them. Caesars is offering -4.5 for -105, the best price and spread combo available at our best college football betting sites. The price implies a 51.22% chance that Houston covers. A $10 bet would pay $9.52.
💰 Best Colorado vs. Houston player prop bet
Our college football player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
⬆️ Conner Weigman Over 191.5 passing yards ⭐⭐⭐⭐
Colorado’s defense allowed Nick Minicucci to throw for 312 yards against them last week, so I love Weigman in this contest. Minicucci threw for 251 yards against Delaware State two weeks ago, but he averaged 8.7 yards per attempt against Colorado.
Because of the blowout nature of the first two Houston games, Weigman hasn’t thrown for 200 yards in a game. However, the Buffaloes are allowing 227.5 pass yards per game against mediocre competition, and they should provide opportunities for Weigman. Weigman has only thrown for 200 yards six times in his career, but considering this matchup, this total is undervaluing him.
FanDuel is offering this total at 190.5, which is one yard less than Caesars. However, Caesars is offering a slightly better price of -111, so I recommend wagering there. The price implies a 52.61% chance Weigman hits this Over. A $10 bet would pay $9.01.
📊 Colorado vs. Houston odds: Week 3
Colorado vs. Houston odds update live in real time.
📈 Colorado vs. Houston opening odds
- Moneyline: Colorado +165 | Houston -200
- Spread: Colorado +4.5 (-110) | Houston -4.5 (-110)
- Over/Under: Over 43.5 (-110) | Under 43.5 (-110)
🔍 Colorado vs. Houston odds analysis
Early in the week, the spread grew to Houston -5.5 at most of our best sports betting sites. However, it has settled back at 4.5, which is a bit surprising considering 70% of bettors are backing the Cougars to cover the spread in this game.
I expect this spread to grow to 5.5 again before kickoff. The total opened at 43.5, and with overwhelming public support for the Over, the number has grown to 45. That’s already a lot of movement, so I don’t expect more growth even if the public continues to show support for the Over.
🔢 Colorado vs. Houston stats
Season stats courtesy of Sports Reference.
Colorado (1-1) | Statistic (per game) | Houston (2-0) |
---|---|---|
25.5 | Points | 31.0 |
17.0 | Points allowed | 4.5 |
+2.5 | Turnover margin | +2.0 |
213.5 | Passing yards | 170.0 |
138.0 | Rushing yards | 197.5 |
227.5 | Passing yards allowed | 78.0 |
202.0 | Rushing yards allowed | 108.0 |
-1.0 | Net yards per play | +2.5 |
📺 Colorado vs. Houston game info
- When: Friday, Sept. 12
- Kickoff: 7:30 p.m. ET
- Where: TDECU Stadium (Houston)
- How to watch: ESPN
❓ Colorado vs. Houston FAQs
Who is favored to win Colorado vs. Houston?
Playing at home, the Cougars are favored to win this game, with a moneyline of -196 or better at every major sportsbook.
What is the spread for Colorado vs. Houston?
The Cougars are favored by 4.5, but with the public overwhelmingly backing Houston to cover, I expect this number to increase.
What is the Over/Under for Colorado vs. Houston?
The Over/Under for this game opened at 43.5, but it has grown to 45.
What are the best bets for Colorado vs. Houston?
The best bets for Colorado vs. Houston are Houston to cover the 4.5-point betting spread and Conner Weigman to hit the Over on his 191.5 passing yards.
When is the Colorado vs. Houston game?
The Colorado vs. Houston game is on Friday, Sept. 12 at 7:30 p.m. ET on ESPN.
How do college football odds work?
When betting on college football, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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