Charlotte vs. South Florida Prediction: College Football Week 6 Odds & Expert Picks

South Florida looks to regain some of the buzz from its historic start to the season when it hosts Charlotte as one of five games on the Friday night college football slate, and I break down this American Conference matchup with my Charlotte vs. South Florida prediction.

The Bulls are a near four-touchdown betting favorite, with kickoff from Raymond James Stadium in Tampa, Fla., set for 7 p.m. ET (ESPN2).

My college football picks back the home favorite, who is fighting to earn the Group of Five College Football Playoff spot this season. Adding to my college football predictions for Week 6 is a contrarian Under on a player who won the American Conference Player of the Week earlier this season.

🏈 Charlotte vs. South Florida predictions

College football expert picks for Week 6; odds subject to change.

• Game pick: South Florida -16.5 first half spread (-105 via DraftKings) ⭐⭐⭐⭐
• Over/Under pick: Over 54.5 (-115 via BetMGM) ⭐⭐⭐
• Player prop bet: Byrum Brown Under 250.5 passing yards (-114 via FanDuel) ⭐⭐⭐⭐

✅ Charlotte vs. South Florida expert pick

Track the latest college football scores for line movement and matchup info.

🐂  South Florida -16.5 first half spread (-105) ⭐⭐⭐⭐

South Florida shocked the college football world by becoming the fourth team in the AP Poll era (since 1936) to win its first two games against ranked opponents as an unranked team. However, since then, the Bulls have been exposed by an elite Miami team in a 49-12 loss before rebounding with a tidy 63-14 win against South Carolina State. 

South Florida essentially controls its own destiny for a College Football Playoff spot as the Group of Five representative, with games against 5-0 North Texas and Memphis squads in two of the next three weeks. 

The Bulls have looked solid defensively all season, save for the Miami blowout, which is not surprising considering they returned 13 of 20 defenders who played at least 200 snaps last year. Meanwhile, Charlotte has scored one first-half touchdown in three games against FBS competition. 

With a huge game against North Texas looming next week, I am limiting this play to just the first half, as the Bulls could take their foot off the gas late. But over the first 30 minutes, the Bulls’ lightning-fast offense should expose a Charlotte defense that allowed 35 points to Monmouth.

I'm headed to DraftKings for this wager, as it is the only of our best college football betting sites charging less than the standard -110 juice (at 52.38% implied odds) to lay the 16.5 points on the first half spread. At a price of -105, a $10 winning wager would net $9.52 in profits.

💰 Best Charlotte vs. South Florida player prop bet

Our college football player prop odds tool shows the best odds for every market across legal sportsbooks in your area.

⬇️  Byrum Brown Under 250.5 passing yards (-114) ⭐⭐⭐⭐

Bulls quarterback Byrum Brown leads all American Conference quarterbacks in yards per attempt and yards per completion, and has gone over this projected total in two of the first four games. He is also coming off a season-high 11.8 yards per attempt average against South Carolina State, while totaling 236 passing yards on a season-low 20 attempts.

He now faces a Charlotte defense that ranks 100th or worse in EPA/pass and overall defensive success rate. But I am doubling down on the theory that the Bulls will play more conservatively in the second half after racing out to a big lead, especially with Brown having been banged up earlier in the season.

I would be interested in backing the Under on Brown’s rushing yards when those odds surface, as the team likely wants him in bubble wrap ahead of a game with North Texas that could determine its eligibility for a conference championship. But this is still a confident four-star play through FanDuel’s -114 odds that carry a 53.27% implied probability. 

If Brown ends the game with 250 or fewer passing yards, my $10 wager would net $8.77 in profits.

📊 Charlotte vs. South Florida odds

Latest college football odds updated live in real time.

📺 How to watch Charlotte vs. South Florida: Week 6

• Date: Friday, Oct. 3
• Kickoff: 7 p.m. ET
• Where: Raymond James Stadium (Tampa, Fla.)
• TV: ESPN2