Buffalo vs. Central Michigan Prediction & Odds: College Football Week 12 Betting Preview

My best Buffalo vs. Central Michigan prediction ahead of Wednesday’s 7 p.m. ET (CBSSN) game at Kelly/Shorts Stadium in Mount Pleasant, Mich., focuses on Buffalo’s strong rush defense slowing down Central Michigan’s run-first offense. Central Michigan is favored by 1 or 1.5 points, depending on the sportsbook.

With MAC championship game hopes hanging in the balance, who will come out victorious on Wednesday? For more coverage of this week’s games, check out our college football Week 12 predictions.

✅ Buffalo vs. Central Michigan prediction & expert picks

See all of our experts' college football picks for Week 12.

📊 Buffalo vs. Central Michigan odds

See live college football odds for every game in Week 12.

🏈 Buffalo vs. Central Michigan preview & score prediction

The one-dimensional nature of the Central Michigan offense is the main reason I’m taking Buffalo to win this game. Central Michigan is averaging 185.3 rushing yards per game, but the Chippewas have had just one game in which their quarterback threw for more than 152 yards.

Buffalo is allowing just 139.3 rushing yards per game and 3.4 yards per carry.

Can Buffalo’s offense spring the victory?

Buffalo is averaging just 24.8 points per game, which ranks 88th in the nation. The Bulls have scored fewer than 30 points in all but three games this season, and they’ve been held to 20 or less in four games

But Central Michigan is allowing 24.0 points per game, and it gave up at least that many to the two best MAC teams the Chippewas have faced. Both of those games resulted in losses. Buffalo’s balanced offensive attack, with 32.6 pass attempts and 34.9 rushes per game, will find enough success against a lackluster defense, as the Bulls’ own defense, allowing just 19.6 per game, holds Central Michigan in check.

BetMGM’s price of +100 implies a 50% chance that Buffalo wins. A $10 bet would profit $10.

Score prediction: Buffalo 21, Central Michigan 17

🆚 Buffalo vs. Central Michigan matchup to watch

Nahree Biggins vs. Buffalo rush defense

While Angel Flores leads the team with 519 yards, the success of the team’s second-leading rusher, Biggins, is more important to the outcome of this game.

Biggins is averaging 5.3 yards per carry, but he’s rushed for 43 yards or fewer in three of his five MAC games, and he ran for 36 yards or fewer in both MAC losses. This season, he’s managed 43 or fewer yards in six of nine games, topping that mark just once against teams allowing fewer than 4.0 yards per carry.

Biggins has yet to top 40 yards in a game where he doesn’t carry the ball at least 10 times, something he’s only done four times, and he has nine or fewer attempts in all four Central Michigan losses.

FanDuel’s price of -114 implies a 43.27% chance that this Under hits. A $10 bet would profit $8.77.

Best prop bet: Under 41.5 rushing yards (-114 via FanDuel)

📈 Buffalo vs. Central Michigan betting trends

🌤️ Buffalo vs. Central Michigan weather

Throwing the ball may be a little tricky, with wind gusts up to 28 mph. However, there’s only a 3% chance of rain, so while it will be a cold 31 degrees, the field conditions shouldn’t be an issue.

📺 How to watch Buffalo vs. Central Michigan

• Date: Wednesday, Nov. 12
• Kickoff: 7 p.m. ET
• Location: Kelly/Shorts Stadium (Mount Pleasant, Mich.)
• TV: CBSSN