Arizona vs. Iowa State Prediction, Odds & Picks: Wildcats to Cover in Ames

Last Updated: September 27, 2025 9:00 AM EDT • 5 minute read X Social Google News Link

My best Arizona vs. Iowa State prediction focuses on why the Wildcats could upset the Cyclones in Saturday’s 7 p.m. ET (ESPN) game at Jack Trice Stadium in Ames, Iowa. The Cyclones are favored by 6.5 points, but the public is split on who they think will cover when making college football predictions for Week 5.
Below, I dive into why the Wildcats covering the spread is one of my best college football picks for this week and why I anticipate Cyclones quarterback Rocco Becht to struggle in this game.
🏈 Arizona vs. Iowa State prediction
College football expert odds subject to change.
- Moneyline pick: Arizona (+200 via bet365) ⭐⭐⭐
- Against the spread pick: Arizona +6.5 (-110 via bet365) ⭐⭐⭐⭐
- Over/Under pick: Under 49.5 (-112 via DraftKings) ⭐⭐⭐⭐
📝 Arizona vs. Iowa State best bet
Track the latest college football scores for line movement and matchup info.
🌵 Arizona +6.5 (-110) ⭐⭐⭐⭐

Questions about the Wildcats’ defense have been answered after they held Kansas State to just 193 yards of total offense two weeks ago. While they allowed 17 points, the one field goal came on a drive of minus-10 yards, and one of Kansas State’s two touchdowns came on a one-play, 75-yard drive.
The Cyclones are averaging nearly 400 yards per game, but quarterback Rocco Becht and his offense have been far from convincing. They’re averaging just 21.3 points against FBS competition, and two of their wins are by just three points.
Arizona quarterback Noah Fifita hasn’t thrown an interception this season. If he takes care of the football again, then the Wildcats, who have a plus-2 turnover margin, can win this game.
The best price available for Arizona +6.5 is -110 at bet365. It implies a 52.83% chance Arizona covers the spread. A $10 bet would pay $9.09.
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💰 Best Arizona vs. Iowa State player prop pick
Our college football player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
⬇️ Rocco Becht Under 235.5 passing yards (-114) ⭐⭐⭐⭐⭐

Becht has thrown for at least 265 yards twice this season. However, in two games against power conference teams, Becht has yet to throw for more than 183.
The Wildcats are allowing just 126.3 passing yards per game. While this average is certainly helped by playing Hawaii and Weber State in their first two games of the year, the defense just held Avery Johnson to 88 yards on 13-of-29 passing. How good was that performance? Johnson threw for 273 yards against Iowa State in Week 0, and he threw for 318 in Week 1.
With this number set at 235.5, this is the best Arizona vs. Iowa State prediction. Arizona’s defense is for real, and the price of -114 at FanDuel is great, especially considering I’d take this Under 215.5. The price implies a 53.27% chance this Under hits. A $10 bet would pay $8.77.
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📊 Arizona vs. Iowa State odds: Week 5
Arizona vs. Iowa State odds update live in real time.
📈 Arizona vs. Iowa State opening odds
- Moneyline: Arizona +200 | Iowa State -250
- Spread: Arizona +6.5 (-110) | Iowa State -6.5 (-110)
- Over/Under: Over 49.5 (-110) | Under 49.5 (-110)
🔍 Arizona vs. Iowa State odds analysis
The betting public is split on the spread and the total for this game, so there has barely been any movement at the best sports betting sites. At the time of writing, 52% of bettors are backing the Under. With so little support for either side, the Over/Under hasn’t moved by more than a half-point anywhere.
As for the spread, 52% of wagers back the Wildcats. While FanDuel’s opening line was 7.5, it has dropped to 6.5 to align with every other major sportsbook. Based on public support, I’d be shocked if this spread hits 7 again before kickoff.
🔢 Arizona vs. Iowa State key stats
Season stats courtesy of Sports Reference.
Arizona (3-0) | Statistic (per game) | Iowa State (4-0) |
---|---|---|
37.0 | Points | 29.8 |
8.7 | Points allowed | 14.2 |
+2.0 | Turnover margin | +0.5 |
248.3 | Passing yards | 222.0 |
189.0 | Rushing yards | 161.0 |
126.3 | Passing yards allowed | 176.0 |
96.0 | Rushing yards allowed | 121.0 |
+2.9 | Net yards per play | +1.1 |
📺 Arizona vs. Iowa State game info
- When: Saturday, Sept. 27
- Kickoff: 7 p.m. ET
- Where: Jake Trice Stadium (Ames, Iowa)
- How to watch: ESPN
❓ Arizona vs. Iowa State FAQs
Who is favored to win Arizona vs. Iowa State?
Iowa State is favored to win this game with a moneyline of at least -225 across the best sports betting apps.
What is the spread for Arizona vs. Iowa State?
The Cyclones are favored by 6.5, and with bettors split almost evenly on who they think will cover, this total is unlikely to hit the key number of 7.
What is the Over/Under for Arizona vs. Iowa State?
The Over/Under for this game is set between 48.5 and 49.5.
What are the best bets for Arizona vs. Iowa State?
The best bets for Arizona vs. Iowa State are the Wildcats to cover as 6.5-point underdogs and Rocco Becht to throw for fewer than 235.5 passing yards.
When is the Arizona vs. Iowa State game?
Saturday’s 7 p.m. ET game between Arizona and Iowa State will air live on ESPN.
How do college football odds work?
When betting on college football, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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Philip Wood X social