The Friday night ESPN game features the Buffalos taking on the Cougars at 7:30 PM ET. SBR's Phil Wood takes a look at this Big 12 matchup in his Colorado vs Houston prediction:
ATS Pick: Houston -4.5 (-105 Caesars)
"The Cougars have dominated their first two games, but considering their opponents, it’s hard to know exactly what this team will look like against better competition. Meanwhile, the Buffaloes lost 27-20 to Georgia Tech in Week 1 and were outgained 463 to 305. And while they won by 24 in Week 2, the Buffaloes only outgained Delaware by two yards.
Colorado has forced three turnovers in each game, which has been a key reason for their success. But Conner Weigman only has seven interceptions in 17 career games, and the Cougars haven’t turned the ball over this season.
The Buffaloes can’t win without turnovers, and Weigman is experienced enough to avoid them."
Best Bet: Conner Weigman Over 191.5 passing yards (-111 Caesars)
"Colorado’s defense allowed Nick Minicucci to throw for 312 yards against them last week, so I love Weigman in this contest. Minicucci threw for 251 yards against Delaware State two weeks ago, but he averaged 8.7 yards per attempt against Colorado.
Because of the blowout nature of the first two Houston games, Weigman hasn’t thrown for 200 yards in a game. However, the Buffaloes are allowing 227.5 pass yards per game against mediocre competition, and they should provide opportunities for Weigman. Weigman has only thrown for 200 yards six times in his career, but considering this matchup, this total is undervaluing him."
Colorado vs Houston Best Odds:

Can the Buffs bounce back or are they in for a long season?
ATS Pick: Houston -4.5 (-105 Caesars)
"The Cougars have dominated their first two games, but considering their opponents, it’s hard to know exactly what this team will look like against better competition. Meanwhile, the Buffaloes lost 27-20 to Georgia Tech in Week 1 and were outgained 463 to 305. And while they won by 24 in Week 2, the Buffaloes only outgained Delaware by two yards.
Colorado has forced three turnovers in each game, which has been a key reason for their success. But Conner Weigman only has seven interceptions in 17 career games, and the Cougars haven’t turned the ball over this season.
The Buffaloes can’t win without turnovers, and Weigman is experienced enough to avoid them."
Best Bet: Conner Weigman Over 191.5 passing yards (-111 Caesars)
"Colorado’s defense allowed Nick Minicucci to throw for 312 yards against them last week, so I love Weigman in this contest. Minicucci threw for 251 yards against Delaware State two weeks ago, but he averaged 8.7 yards per attempt against Colorado.
Because of the blowout nature of the first two Houston games, Weigman hasn’t thrown for 200 yards in a game. However, the Buffaloes are allowing 227.5 pass yards per game against mediocre competition, and they should provide opportunities for Weigman. Weigman has only thrown for 200 yards six times in his career, but considering this matchup, this total is undervaluing him."
Colorado vs Houston Best Odds:
Can the Buffs bounce back or are they in for a long season?