Tottenham vs. Manchester City Prediction, Premier League Betting Odds & Expert Picks: Matchweek 2

After an exciting match at London Stadium kicked off Matchweek 2 in the Premier League, my Tottenham vs. Manchester City prediction expects sparks to fly again in Saturday's opener.

Kickoff is set for 7:30 a.m. ET (USA Network) from Etihad Stadium in Manchester, England. The Cityzens are -200 betting favorites on the 3-way moneyline, according to the Premier League odds.

My Premier League best bets believe Tijjani Reijnders will once again play an important part in the hosts taking all three points from the contest.

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📊 Tottenham vs. Manchester City odds: Matchweek 2

Live updated odds from our best soccer betting sites.

📈 Tottenham vs. Manchester City betting odds analysis

It's always a surprise when one Big Six side is listed as a -200 favorite over another. While Manchester City is the popular public pick, I'd be surprised if the hosts' odds continued to shorten. Tottenham has won two of its last three against the Cityzens, so many bettors could see value in Spurs at plus money (+525).

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⚽ Tottenham vs. Manchester City expert picks

Soccer picks made Friday; odds subject to change.

✅ Moneyline pick: Manchester City moneyline (-200 via ESPN BET) ⭐⭐⭐⭐
✅ Against the spread pick: Tottenham +1.5 (-161 via Caesars) ⭐⭐⭐⭐
✅ Over/Under pick: Under 3.5 goals (-145 via Caesars) ⭐⭐⭐

🔮 Tottenham vs. Manchester City prediction & best bet

🔎 Our NEW player props odds tool can help you find the best betting odds across legal sportsbooks in your area!

⛵️ Manchester City to win (-200) ⭐⭐⭐⭐

You only need two adjectives to describe Manchester City's season-opening win over Wolves: Classy and clinical. Fine, for the sake of alliteration, let's add "clean sheet." It was business as usual for Pep Guardiola's men as they cruised to a 4-0 victory at Molineux.

While Tottenham picked up all three points in a dominant 3-0 display over newly promoted Burnley, I'm not confident those attacking numbers will translate in a matchup against one of the best teams on the planet. Spurs could have issues creating chances due to the absence of an innovative attacking midfielder.

Son Heung-min moved to the MLS, James Maddison is sidelined with a serious injury, Morgan Gibbs-White stayed at Nottingham Forest, and Tottenham was beaten to the signing of Eberechi Eze by Arsenal. Savinho could make a switch from City to Spurs after the match, but by then, it'll be too little too late.

I believe Manchester City should be heavily favored in this match. However, if you don't want to lay the -200 odds with the best sports betting sites, I'd recommend taking Tottenham to cover the 1.5-goal spread (-161).

Guardiola has faced Thomas Frank eight times in his managerial career, and Manchester City won by two goals or more just twice in that span. I'm of the mindset that the former Brentford boss can set up to keep this game closer than the spread suggests, with better players at his disposal this time around.

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💰 Best Tottenham vs. Manchester City player prop bet

🪄 Tijjani Reijnders to score or give an assist (+100) ⭐⭐⭐

As I alluded to in the prior pick, I believe Frank will set the visitors up to absorb pressure through a compact defensive shape. Tottenham will be happy to concede possession at the expense of defensive solidity, which means Manchester City will need a versatile playmaker to part the parked bus.

I believe Reijnders will be that magician in the middle of the park. The Cityzens' shiny new $64.5 million toy tallied two goal contributions in his Premier League debut. The Dutch midfielder showed he's more than capable of picking up the creative baton left behind by Kevin De Bruyne's departure.

Reijnders is listed at even money to get on the stat sheet again on Saturday morning, implying a 50% probability he adds to his season totals. A winning $10 wager at the best sportsbooks profits $10.

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🚑 Tottenham vs. Manchester City injuries

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📺 Tottenham vs. Manchester City game info

• When: Saturday, Aug. 24
• Kickoff: 7:30 a.m. ET
• Where: Etihad Stadium (Manchester, England)
• How to watch: USA Network

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 🔮 Premier League expert picks

• Premier League predictions for Matchday 2
• Chelsea vs. West Ham prediction
• Tottenham vs. Man City prediction
• Leeds United vs. Arsenal prediction
• Man United vs. Fulham prediction

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❓Tottenham vs. Manchester City FAQs

Who is the favorite to win Tottenham vs. Manchester City?

Manchester City is a -200 betting favorite to beat Tottenham by the 3-way moneyline odds.

How do soccer spread odds work?

When betting on soccer, the favorite needs to win by a certain number of goals to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the number of goals displayed in the spread or win outright to cash. For example, a 1.5-goal favorite would need to win by 2 or more goals to reward bettors.

How do soccer moneyline odds work?

Unlike some other sports, soccer often features "3-way moneyline odds" allowing bettors to wager on a win for either side or a draw. You can also wager on the "2-way moneyline" to remove the draw option, but you'll get better odds on each team in a 3-way market.

Where can I find the best Premier League betting odds?

Shop around our best sportsbooks to find the best odds for your Premier League picks. Our best sports betting apps for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.

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