Liverpool vs. Newcastle Prediction, Premier League Betting Odds & Expert Picks: Matchweek 2

There is no shortage of riveting storylines as Liverpool head to Tyneside to face Newcastle, as we offer our prediction for Monday's clash.

Gary Pearson

Last Updated: August 25, 2025 6:57 AM EDT • 5 minute read

Liverpool vs. Newcastle Prediction, EPL Betting Odds & Expert Picks: Matchweek 2 — Pictured: Mo Salah in action against Bournemouth as we offer our Liverpool vs. Newcastle prediction. Photo by Peter Byrne via Imagn Images.

The storylines are equal measures plentiful and compelling for the culmination of Matchweek 2 as we offer our Liverpool vs. Newcastle prediction.

Liverpool, among the Premier League odds front-runners, travel to Tyneside for today's match as the favorites across our best soccer betting sites.

Kickoff from St James' Park in Newcastle is set for 3 p.m. ET (USA Network), and our Premier League best bets below take stock of the numerous narratives, focusing on the home side's limited attacking options.

📊 Liverpool vs. Newcastle odds: Matchweek 2

Live updated odds from our best sports betting sites.

📈 Liverpool vs. Newcastle betting odds analysis

Liverpool is the +125 betting favorite for Monday's away Premier League match at Newcastle, with the home side receiving +200 moneyline odds at DraftKings. The Reds had the best away record last season, while the Magpies were sixth best on their home patch.

The total is juiced heavily toward the Over at 2.5 goals (-190 at DraftKings). That's mainly due to Liverpool's prolific attack, with the team's 3-3 tie at St James' Park last season factoring in.

⚽ Liverpool vs. Newcastle expert picks

Soccer picks made Monday; odds subject to change.

✅ Moneyline pick: Liverpool (+125 via DraftKings) ⭐⭐⭐⭐
✅ Against the spread pick: Liverpool -0.5 (+110 via DraftKings) ⭐⭐⭐
✅ Over/Under pick: Under 3.5 goals (-160 via Caesars) ⭐⭐⭐

🔮 Liverpool vs. Newcastle prediction & best bet

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🔴 Liverpool moneyline (+125) ⭐⭐⭐⭐

Under ordinary circumstances, St James' is inarguably one of the most challenging venues to eke a result for visiting sides. Tonight's match falls under the category of extraordinary, as Newcastle supporters have an unlimited supply of kerosene to toss on the already uncontrollable wildfire.

Alexander Isak will not play, with his demand for a transfer to Liverpool at the forefront of the narrative. Like a magpie being shot at by a child wielding a slingshot, that has angered Newcastle supporters to no end. It will make the atmosphere even more hostile, but the Magpies are without their only elite out-and-out striker.

Anthony Gordon is doing his utmost to fill in as the central striker, but his attributes are better suited to supporting the frontman. Liverpool's defense is by no means airtight, but I'm not confident in an attack led by Gordon, Anthony Elanga, and Harvey Barnes.

My confidence level drops even more when pitting it against Liverpool's outlandishly talented and prolific attack, led by Mohamed Salah, Florian Wirtz, and Hugo Ekitike. As if the Toon Army doesn't have enough to boil their collective blood, they will still be aggrieved by Ekitike's landing in Liverpool. Newcastle made several attempts at signing the Frenchman before he decided to join the Reds.

While that resentment and rancor will make for a hostile visit for Arne Slot's side, the visitors' decided advantage in the attacking third will provide the difference. And let's not forget that Liverpool are unbeaten in 17 Premier League matches against Newcastle.

Our best sports betting apps offer plus-money odds for a Reds win, with DraftKings providing the biggest number.

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💰 Best Liverpool vs. Newcastle player prop bet

⚽ Mohamed Salah anytime goal scorer (+150) ⭐⭐⭐

Salah opened his season account with an insurance marker deep in stoppage time against Bournemouth at Anfield in the opener. He scored a brace against Newcastle at St James' Park in last season's thrilling 3-3 draw. Salah has 10 goals in 17 Premier League matches against the Magpies, four of which occurred in the previous three.

BetMGM offers +150 odds, the best value of the best sportsbooks. That will yield a $15 profit on a winning $10 bet, $3 more than Caesars and FanDuel's +120, which is at the low end of the market. DraftKings offers +140 while bet365 has +130 for Salah to score.

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🚑 Liverpool vs. Newcastle injuries

📺 Liverpool vs. Newcastle game info

When: Monday, Aug. 25
Kickoff: 3 p.m. ET
Where: St James' Park (Newcastle, England)
How to watch: USA Network, Fubo TV

❓ Liverpool vs. Newcastle FAQs

Who is the favorite to win Liverpool vs. Newcastle?

Liverpool is the favorite on the 3-way moneyline to beat Newcastle in today's match, with odds of +125 at DraftKings.

How do soccer spread odds work?

When betting on soccer, the favorite needs to win by a certain number of goals to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the number of goals displayed in the spread or win outright to cash. For example, a 1.5-goal favorite would need to win by 2 or more goals to reward bettors.

How do soccer moneyline odds work?

Unlike some other sports, soccer often features "3-way moneyline odds" allowing bettors to wager on a win for either side or a draw. You can also wager on the "2-way moneyline" to remove the draw option, but you'll get better odds on each team in a 3-way market.

Where can I find the best Premier League betting odds?

Shop around our best sportsbooks to find the best odds for your Premier League picks. Our best sports betting apps for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.

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Written by:
Gary Pearson

Gary Pearson has written professionally since 2010, focusing on sports betting since 2014. Before entering the sports betting space, he contributed to the Canadian Press, FanSided, the Hockey Writers, the Calgary Herald, and other publications. His work has also been featured in Sports Illustrated and Bleacher Report. Gary, who consumes sports like a blue whale devours plankton, has a penchant for writing predictions and analyses across several sports, including hockey, soccer, football, tennis, and more. He bets regularly, preferring single-game picks, props, and live betting. While there isn't a sport he has yet to dabble in, Gary prefers betting on soccer, hockey, and football. He studied at various post-secondary institutions, including the University of Calgary, SAIT Polytechnic, and Griffith University, located in Brisbane, Australia. Gary has a marketing degree and completed his bachelor's degree in journalism at Griffith University. He feels strongly that life experience is as essential as post-secondary education, helping formulate more accurate predictions and analyses. Gary believes that competing at a high level of amateur sports during his formative years helped him better understand an athlete's psyche and the nuances and complexities of a team's dynamic, both on and off the playing surface. He feels that knowledge is immeasurably important when offering his analytical expertise. He has lived on five continents and currently resides in Canada.