Brentford vs. Manchester United Prediction Today: Matchweek 6 Best Bets

Last Updated: September 27, 2025 7:00 AM EDT • 4 minute read X Social Google News Link

My Brentford vs. Manchester United prediction analyzes how the visitors’ positive momentum will carry over when the action gets underway in less than an hour. Gtech Community Stadium in London is the site of the Matchweek 6 opening affair at 7:30 a.m. ET (USA Network).
Manchester United are the +105 betting favorite on the heels of an encouraging run as they visit a Brentford squad struggling to start the season. My soccer picks predict a high-scoring game, with a Red Devils forward shining against his former club.
⚽ Brentford vs. Manchester United prediction
Premier League expert picks based on odds that are subject to change.
- Moneyline pick: Draw (+280 via DraftKings) ⭐⭐⭐
- Against the spread pick: Brentford +0.5 (-130 via DraftKings) ⭐⭐⭐⭐⭐
- Over/Under pick: Over 2.5 (-150 via Caesars) ⭐⭐⭐⭐
📝 Brentford vs. Manchester United preview & best bet
🥳 Both teams to score (-175) ⭐⭐⭐⭐⭐
Ruben Amorim’s resurgent Red Devils will try to win consecutive Premier League games for the first time under the Portuguese head coach when they visit Brentford.
They might have only recorded one away goal all season, but I like Manchester United’s chances of scoring at Gtech Community Stadium against a Brentford team coming off a humbling 3-1 defeat to Fulham.
However, no defense has been stopping the Bees from scoring across seven games this season. Despite losing a pair of attacking stars over the summer, Brentford continue to be a legitimate threat in front of goal this campaign.
And with United yet to keep a clean sheet, I’m taking both teams to score in this contest. bet365 is posting the leading odds at -175 among the best sports betting sites, with a winning $10 bet netting a profit of $5.71.
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💰 Best Brentford vs. Manchester United player prop bet
🔥Bryan Mbeumo to score or assist (+115) ⭐⭐⭐⭐⭐
Bryan Mbeumo has been knocking on the door recently, but he has yet to add to his lone Premier League goal contribution this season. That could be about to change when he goes up against his former club Brentford.
After averaging just over a shot on target across his last three contests, an uptick in aggressiveness at the Gtech will result in him scoring, or at least providing an assist on Saturday.
Along with trying to justify his transfer to United fans, Mbeumo will be motivated to produce a quality performance at the stadium he called home for six years. He scored 70 times during his Brentford career, including 20 last season in the Premier League (12 goals at home and eight on the road).
Expect him to cause plenty of trouble for a Brentford defense that’s been looking shaky thus far. Of the best sports betting apps, the top odds can be found at FanDuel, which is setting the line at +115. A winning $10 bet would lead to a $11.50 profit.
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📊 Brentford vs. Manchester United odds: Matchweek 6
Premier League odds update live in real time.
📈 Brentford vs. Manchester United betting odds analysis
The odds heading into this encounter aren't surprising given each team's recent run of form. Manchester United are getting the edge as expected while listed at +105, a slight uptick from the opening odds. But banking on the Red Devils performing well is never safe under the current regime. I foresee this clash ending in a draw, which both teams will ultimately be content with after the dust settles.
🔢 Brentford vs. Manchester United results
Brentford vs. Manchester history courtesy of 11v11.com.
Date | Competition | Result | Location |
May 4, 2025 | Premier League | Brentford 4-3 Manchester United | Gtech Community Stadium |
Oct. 19, 2024 | Premier League | Manchester United 2-1 Brentford | Old Trafford |
March 30, 2024 | Premier League | Brentford 1-1 Manchester United | Gtech Community Stadium |
Oct. 7, 2023 | Premier League | Manchester United 2-1 Brentford | Old Trafford |
April 5, 2023 | Premier League | Manchester United 1-0 Brentford | Old Trafford |
🚑 Brentford vs. Manchester United injury report
📺 Brentford vs. Manchester United game info
- When: Saturday, Sept. 27
- Kickoff: 7:30 a.m. ET
- Where: Gtech Community Stadium (London)
- How to watch: USA Network
❓ Brentford vs. Manchester United FAQs
Who is favored to win Brentford vs. Manchester United?
Manchester United are the favorites at +105, while Brentford sit at +240.
What is the spread for Brentford vs. Manchester United?
The spread is at -0.5 for Manchester United, with odds of -105 at DraftKings.
What is the Over/Under for Brentford vs. Manchester United?
The total for Brentford vs. Manchester United is set at 2.5, with the Over set at -150 and the Under at +123.
What are the best bets for Brentford vs. Manchester United?
Both teams to score and Bryan Mbeumo to score or assist are my best bets for Brentford vs. Manchester United.
When is the Brentford vs. Manchester United game?
Brentford vs. Manchester United kicks off Saturday at 7:30 a.m. from Gtech Community Stadium in West London.
How do soccer odds work?
When betting on soccer, the spread shows how many goals the favorite needs to win by in order to cash the bet. For example, a favorite of -1.5 must win by 2 or more goals to cover the spread, while an underdog at +1.5 must win outright or lose by fewer than 1 goal to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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Gordon Brunt