Barcelona vs. Inter Milan Prediction: Expert Picks & Odds for Champions League Semifinals

Gabe Henderson makes his Barcelona vs. Inter Milan prediction ahead of the pivotal second leg of the Champions League semifinal from the San Siro.
Barcelona vs. Inter Milan Prediction: Expert Picks & Odds, 5/6
Pictured: Dani Olmo and Lautaro Martinez during the UEFA Champions League semifinals first leg between FC Barcelona and Inter Milan. Photo by Sergio Ruiz / Imago via Sipa USA.

The first ticket to Munich for the 2025 Champions League final will be punched on Tuesday when Barcelona and Inter Milan square off. Our Barcelona vs. Inter Milan prediction analyzes which team has an advantage heading into the second leg of the Champions League semifinal, which is currently tied on aggregate at 3-3.

The Champions League odds give the visitors the slight advantage with moneyline odds of +135. The action from the San Siro in Milan gets underway at 3 p.m. ET (Paramount+).

Read on for our expert picks and a player prop bet for the highly anticipated UCL semifinal clash.

💰 Barcelona vs. Inter Milan expert picks: Champions League semifinal

Check out all of our soccer picks for the Champions League and more.

✅ Against the spread pick: Barcelona -0.5 (-105 via DraftKings) ⭐⭐⭐
✅ Moneyline pick: Barcelona ML (+135 via DraftKings) ⭐⭐⭐
✅ Over/Under pick: Under 3.5 goals (-135 via
ESPN BET) ⭐⭐⭐

💡 Barcelona vs. Inter Milan prediction & best bet

🎯 Score prediction: Barcelona 2, Inter Milan 1

These teams played out one of the most entertaining matches of the tournament in the first leg, eventually splitting the spoils following a 3-3 draw at the Estadi Olimpic Lluis Companys in Barcelona. Inter Milan took an early 2-0 lead before the hosts woke up and overwhelmed the reigning UCL finalists with their clinical attack.

Hansi Flick's men were able to control possession and pick apart a disciplined Inter Milan back line with relative ease after falling behind in the first half hour. If the second leg continues this war of attrition, I believe it's Barcelona that have the leg up on their competition.

While Lautaro Martinez and Marcus Thuram have proven themselves time and time again in this competition, the Blaugrana have depth and goal-scoring threats at every position. This is especially true with a wealth of healthy options up top, including an experienced goal scorer whom we will discuss more below.

Simply put, Flick's team has looked unflappable this season. Barcelona sit atop La Liga, they won the Copa del Rey, and a spot in the Champions League final would move the Blaugrana one step closer to the coveted treble.

The visitors are adaptable, and they've already displayed their ability to overcome adversity in the biggest moments. These traits cannot be taught, and while Inter Milan undoubtedly possesses similar qualities, it's Barcelona's attacking tactics and talent that give them an edge in our book during this nervy second leg.

✅ Best bet: Barcelona ML (+135 via DraftKings)

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⚽ Best Barcelona vs. Inter Milan player prop bet

🔎 Our NEW player prop odds tool can help you find the best betting odds across legal sportsbooks in your area!

🔥 Robert Lewandowski anytime goalscorer ⭐⭐

After missing the first leg with a muscle injury, Lewandowski is back in the Blaugrana's matchday squad for the second leg against Inter. However, he'll be on the bench for Barcelona, as he's not yet 100% match fit. We're recommending the team's second-leading UCL goalscorer as a two-star play due to his uncertain minutes.

If Lewandowski sees the pitch - which Flick has said he will, if the situation calls for it - he's almost a lock to score. The Polish No. 9 has netted 11 goals in 12 Champions League appearances, including an important brace against Dortmund, and 40 in 48 games overall. It's rare to see Lewandowski at plus money as an anytime goal scorer.

The talisman's goal-scoring record is what sets him apart from his striking counterpart, Ferran Torres, who has just three goals in the European competition this year.

However, seeing as Torres scored in the first leg and will command minutes as the center forward, he's worth a flyer at +210 betting odds, as well. Inter's Martinez is also the safest anytime goal-scorer bet (+120) for the hosts.

 Best odds: +115 via BetMGM

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📈 Barcelona vs. Inter Milan odds

Live updated odds from our best sports betting sites.

🚑 Barcelona vs. Inter Milan injury report

📡 How to watch Barcelona vs. Inter Milan live  

📅 Tuesday, May 6
🕗 3 p.m. ET
📍 San Siro (Milan)
🛜 Paramount+

💵 Best soccer betting sites

Want to bet on the UEFA Champions League? Here are the best soccer betting sites and the best sportsbook promos for today's UCL match.

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