Atletico Madrid vs. Inter Milan Prediction & Odds: Champions League Betting Preview for Nov. 26
Last Updated: November 25, 2025 12:50 PM EST • 3 minute read X Social Google News Link
The stage is set for an important Champions League clash at Metropolitano Stadium in Madrid on Wednesday, and my Atletico Madrid vs. Inter Milan prediction backs the visitors to maintain their unbeaten record.
My Champions League best bets analyze how Atletico Madrid - despite being a +130 betting favorite - will struggle to contain last season’s runner-up Inter Milan, who have one of the best defensive records in the Champions League. The action starts at 3 p.m. ET on Paramount+.
✅ Atletico Madrid vs. Inter Milan prediction & expert picks
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💵 Best Atletico Madrid vs. Inter Milan bets
⚽ Atletico Madrid vs. Inter Milan preview & score prediction
Inter Milan return to Champions League action with a point to prove after a setback over the weekend domestically.
Although facing Atletico Madrid is never easy, especially on the road, I’m targeting Inter Milan to maintain their unbeaten record by winning or drawing Wednesday.
Inter Milan set to bounce back
Despite being one of three teams with a perfect record through four Champions League games, Inter Milan saw their four-game winning streak in all competitions end Sunday with a 1-0 defeat to rivals AC Milan.
They had more shots on target and controlled possession against AC Milan, but failed to score in a game for the first time this season.
Don’t expect them to get shut out again. I’m expecting goals to flow in this encounter and for Inter Milan to escape with at least a point against Atletico.
Atletico are on a five-game winning streak in all competitions, but Diego Simeone’s side has been inconsistent in the Champions League, leaving the club in 17th place. Defense has been an issue, as Atleti have conceded over two goals a game.
A successful $10 bet on Inter Milan, who have only conceded one goal in the Champions League, winning or drawing delivers a profit of $6.15 at bet365.
Score prediction: Inter Milan 2, Atletico Madrid 1
🆚 Atletico Madrid vs. Inter Milan matchup to watch
Marcus Thuram vs. Atletico’s defense
Marcus Thuram will be at the forefront of the action Wednesday, as Inter Milan will focus their attacking efforts on getting the French forward, as well as Lautaro Martinez, the ball as much as possible.
As Thuram tries to silence the home crowd, things could get physical when Atletico defenders try to stop the imposing 28-year-old, who has two Champions League goals this season.
Similar to his last two Serie A appearances, I’m backing the fearless forward to get fouled at least two times when he tries to break through Atletico’s back line.
A winning $10 bet on Thuram getting fouled Over 1.5 times nets a profit of $11 at bet365.
Best prop bet: Marcus Thuram to be fouled Over 1.5 (+110 via bet365)
📊 Atletico Madrid vs. Inter Milan odds
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📈 Atletico Madrid vs. Inter Milan betting trends & recent form
| Atletico Madrid | Statistic | Inter Milan |
|---|---|---|
| 2-0-2 | Champions League record | 4-0-0 |
| 1-0-1 | H2H record | 1-0-1 |
| L-W-L-W | Last 5 games | W-W-W-W |
| Won 1-0 at Getafe | Previous result | Lost 1-0 vs. AC Milan |
| Atletico have won eight of their last 10 UEFA competition games at home against Italian teams | Key stat | Inter have lost only one of their last eight UEFA competition games against Spanish teams |
🌤️ Atletico Madrid vs. Inter Milan weather
Conditions will be ideal for Atletico’s clash vs. Inter in Madrid, with temperatures set to be around 48 degrees and no rain in the forecast.
📺 How to watch Atletico Madrid vs. Inter Milan
- Date: Wednesday, Nov. 26
- Kickoff: 3 p.m. ET
- Location: Riyahd Air Metropolitano Stadium (Madrid)
- TV: Paramount+
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