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TreVeyon Henderson #32 of the Ohio State Buckeyes scores a touchdown as we look at our Ohio State vs. Michigan prediction
TreVeyon Henderson #32 of the Ohio State Buckeyes scores a touchdown during the second quarter of a game against the Michigan State Spartans at Ohio Stadium on November 11, 2023 in Columbus, Ohio. Photo by Ben Jackson/Getty Images via AFP.

On Saturday, Michigan and Ohio State will clash in one of the biggest matchups in the storied history of their rivalry, and we have you covered with our top Ohio State vs. Michigan prediction, grounded in the best college football odds.

The winner of this year's edition of "The Game" will progress to the Big Ten title game and contend for the national title. In a showdown between two undefeated teams, the stakes are high as No. 3 Michigan faces No. 2 Ohio State. Meanwhile, the loser might find itself outside looking in on the College Football Playoff.

Ohio State is looking to reverse a recent trend, having lost the previous two matchups in this series. The Buckeyes hope to avoid its first three-game losing streak since 1995-97. This upcoming game is significant for Ohio State as it aims to break the current pattern and prevent a rare occurrence of consecutive losses in this particular series—a situation not experienced by Ohio State in nearly two decades.

As part of our college football best bets for Saturday, here is our best Ohio State vs. Michigan prediction to accompany our Ohio State vs. Michigan college football player props (odds via our best college football betting sites; pick confidence based on a 1-to-5-star scale).

Ohio State vs. Michigan prediction: "The Game"

TreVeyon Henderson Over 14.5 receiving yards (-115 via bet365) ⭐⭐⭐⭐

In what should be a defensive battle, we like betting on Ohio State running back TreVeyon Henderson to maintain his recent form during this rivalry matchup. We project 24 receiving yards for Henderson, who has looked much healthier and been more of a dynamic weapon for the Buckeyes of late.

Henderson has cleared 100 yards on the ground in four of his last five outings, including a 15-carry, 146-yard performance against Minnesota last weekend. But his threat as a receiver has gone a bit under the radar.

In the last four weeks, Henderson has recorded 13 catches for 165 yards and cleared this mark in all but one contest. That volume is a promising sign ahead of this matchup, but Henderson is certainly capable of clearing this mark on one play given his average of 13.1 yards per reception this season.

What I like most about this prop is that Henderson will rarely be asked to pick up a blitz instead of running a route. According to PFF, Henderson has been on the field for 171 passing plays and was charted as a pass blocker on just 43 of those snaps. Over his last four outings, Henderson has blocked on 20 of his 79 snaps.

The Wolverines have been elite on the defensive end this season, and they will certainly try to limit Henderson's impact on the ground. It could be more of a passing game script than usual for Ohio State, so look for Henderson to remain involved as one of the top playmakers on this offense.


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Ohio State vs. Michigan bonus codes

Ohio State vs. Michigan best odds

bet365 (-115)

Over 15.5 receiving yardsN/AN/AOver 14.5 receiving yardsOver 14.5 receiving yards

With this prop only available at a few of our best sports betting apps, it makes it really easy to place this wager at bet365. Based on our projection, we wouldn't play this any higher than 14.5 receiving yards and wouldn't pay more than -120 vig for this Over.

Ohio State vs. Michigan odds

Ohio State vs. Michigan odds analysis

When the lookahead lines were released in the summer, Michigan opened as a slight 1.5-point favorite at home. The spread is now north of a field goal as of this week, with the Wolverines laying -3.5 across our best sportsbooks.

The total started north of 60 in the offseason, but the latest line is nowhere near that range. We are seeing a total between 45.5 and 46.5 across the board as of Wednesday afternoon.

Ohio State vs. Michigan game info

  • When: Saturday, Nov. 25 at Noon ET
  • Where: Michigan Stadium, Ann Arbor, MI
  • How to watch: FOX
  • Weather: 34 degrees, 7 mph winds, 2% precipitation

Ohio State-Michigan prediction made 11/22/2023 at 10:40 a.m. ET.

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