49ers vs. Rams Expert Picks: Thursday Night Football Best Bets & TNF Predictions
The San Francisco 49ers (3-1) and Los Angeles Rams (3-1) battle tonight for the NFC West lead on Thursday Night Football (8:15 p.m. ET, Prime Video), and our 49ers vs. Rams expert picks expect the home favorites to prevail with our best NFL picks for this matchup at SoFi Stadium in Los Angeles.
🏈 49ers vs. Rams expert picks: Thursday Night Football
NFL expert picks for Thursday Night Football with pick confidence based on 1-to-5-star scale; see the latest NFL odds for the best available price.
- Game pick: Rams -5.5 (-122 via FanDuel) ⭐⭐⭐⭐
- Player prop pick: Puka Nacua Over 95.5 receiving yards (-114 via FanDuel) ⭐⭐⭐⭐
- Touchdown scorer prediction: Davante Adams to score anytime TD (+105 via Caesars) ⭐⭐⭐⭐⭐
- First touchdown prediction: Christian McCaffrey to score first TD (+650 via DraftKings) ⭐⭐⭐⭐
💰 Thursday Night Football predictions & best bets
Track the latest NFL scores for line movement and matchup info.
✅ Best 49ers vs. Rams pick
Here's what our NFL expert Gary Pearson wrote this week on why he's betting Los Angeles to cover the spread at home against rival San Francisco tonight on Thursday Night Football:
🐏 Dolphins -5.5 (-122) ⭐⭐⭐⭐
A presumed Mac Jones-led offense already devoid of tight end George Kittle won't cause any sleepless nights for a Rams defense that has the eighth-best EPA per play.
With Jones at the helm, the 49ers' offense struggled to produce against an average Arizona Cardinals defense, scoring their only touchdown in the fourth quarter.
Pearson offers his full analysis for betting the Rams, along with his Over/Under pick and best player prop bet for Thursday Night Football, in his 49ers vs. Rams prediction.
🔥 Best 49ers vs. Rams player prop pick
Here's why our NFL expert Matt Jacob is backing Rams wide receiver Puka Nacua to torch the 49ers' secondary tonight on Thursday Night Football:
⬆️ Puka Nacua Over 95.5 receiving yards (-114) ⭐⭐⭐⭐
How dominant has Puka Nacua been to start the season? The Rams wideout has eight more receptions and 101 more yards than any other NFL receiver. His per-game yardage output since Week 1 is 130, 91, 112 and 170 yards. Nacua also recorded double-digit receptions three times.
San Francisco’s defense has been solid against the pass so far, allowing 165 yards per game (sixth-best in the NFL). The Niners shut down Jacksonville’s Brian Thomas Jr. (49 yards) and Arizona’s Marvin Harrison Jr. (44 yards). But they also got shredded by Seattle’s Jaxon Smith-Njigba, who had 124 yards in the opener. San Francisco has also watched Nacua rack up 97 and 147 receiving yards in two of three career meetings.
While Jacob is backing Nacua to have a big night, he's also fading two former Pro Bowl stars tonight with his 49ers vs. Rams player props. We also broke down the best bets for the Rams star in our Puka Nacua player props.
💪 Best 49ers vs. Rams anytime touchdown scorer prediction
Here's why our NFL expert Esten McLaren is betting on Rams wide receiver Davante Adams to score a touchdown as one of his best anytime touchdown scorer bets for Thursday Night Football:
🐏 Davante Adams anytime touchdown scorer (+105) ⭐⭐⭐⭐⭐
Davante Adams has played more snaps than Puka Nacua, the Rams' No. 1 receiver, in all but one game thus far. Though he's topped 56 yards just once, he scored a touchdown in three straight games entering Thursday Night Football.
The 49ers are allowing opposing receivers to catch 66.1% of their targets at a 7.11-yard average. While they've surrendered just two touchdowns to the position, Adams and QB Matthew Stafford present a stiffer test.
McLaren is also backing Rams backup running back Blake Corum and 49ers fill-in receiver Kendrick Bourne with his anytime touchdown scorer predictions.
🥇 Best 49ers vs. Rams first touchdown scorer prediction
Here's why our NFL expert Sean Tomlinson is betting on 49ers running back Christian McCaffrey to score the first touchdown on Thursday Night Football:
⛏️ Christian McCaffrey first touchdown scorer (+650) ⭐⭐⭐⭐
The 49ers are severely limping on offense heading into this game - Mac Jones steps under center for the injured Brock Purdy while wide receivers Jauan Jennings and Ricky Pearsall and tight George Kittle also remain out.
With few of his regular options elsewhere, the journeyman Jones will no doubt seek familiarity early in the game. And for the 49ers, the one steadily healthy option so far has somehow been McCaffrey.
Tomlinson is also backing Adams to score tonight while taking a shot on an under-the-radar 49ers wideout with his first touchdown scorer predictions.
🚀 Best 49ers vs. Rams parlay
Here's what our NFL expert Brenden Schaeffer has cooked up for his best 49ers vs. Rams parlay for Thursday Night Football:
👀 Best 49ers vs. Rams parlay for TNF
- Rams -7.5 (-120) ⭐⭐⭐⭐
- Christian McCaffrey Over 6.5 receptions (-140) ⭐⭐⭐⭐
- Demarcus Robinson Over 29.5 receiving yards (-112) ⭐⭐⭐⭐
Best odds: +476 via FanDuel ($10 to win $47.60)
📺 How to watch Thursday Night Football
- Date: Thursday, Oct. 2
- Kickoff: 8:15 p.m. ET
- Where: SoFi Stadium (Inglewood, Calif.)
- TV: Prime Video
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