Best March Madness Parlay Today: Friday's Best Moneyline Picks & Bets at +9944 Odds

Entering the second day of the NCAA Tournament, we've put together our best March Madness moneyline parlay based on our expert score predictions.

C Jackson Cowart

Last Updated: March 21, 2025 12:02 PM EDT • 9 minute read

Best March Madness Parlay Bets Today: Friday's Best Moneyline Picks — Pictured: Michigan State guard Jeremy Fears Jr. reacts to a foul committed by Oregon guard Jackson Shelstad. Photo by Junfu Han via Imagn Images.

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With 16 NCAA Tournament games tipping off today starting at 12:15 p.m. ET, we've put together our best March Madness parlay based on our moneyline picks for every game.

Our best March Madness parlay bets today combine for a betting ticket with +9944 odds, which would turn a $10 bet into a $994.43 profit. While it may seem like a long shot, it's a lot more likely than a perfect bracket, and our college basketball experts are backing all these teams to win today.

👉 Can't get enough March Madness action? Check out the rest of our March Madness first-round expert picks as part of our March Madness predictions.

💰 Our best March Madness parlay bets today for the NCAA Tournament

📅 Check out the full March Madness first-round schedule & opening odds.

🔥 Baylor (+105) vs. Mississippi State
🔥 Alabama (-5000) vs. Robert Morris
🔥 Iowa State (-1111) vs. Lipscomb
🔥 Colorado State (-120) vs. Memphis
🔥 Duke (-10000) vs. Mount St. Mary's
🔥 Saint Mary's (-189) vs. Vanderbilt
🔥 Ole Miss (+105) vs. North Carolina
🔥 Maryland (-556) vs. Grand Canyon
🔥 Florida (-10000) vs. Norfolk State
🔥 Kentucky (-714) vs. Troy
🔥 Marquette (-179) vs. New Mexico
🔥 Arizona (-1111) vs. Akron
🔥 UConn (-227) vs. Oklahoma
🔥 Illinois (-161) vs. Xavier
🔥 Michigan State (-2000) vs. Bryant
🔥 Oregon (-303) vs. Liberty

🚀 Best parlay odds: +9944 via Caesars ($10 to win $994.40)

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🔮 March Madness score predictions & moneyline odds for every game

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🏀 Mississippi State vs. Baylor prediction, 12:15 p.m. ET (CBS)

🎯 Score prediction: Baylor 73, Mississippi State 71
💰 Best Baylor moneyline odds: +112 via FanDuel

Here's why Mike Spector is picking Baylor to win outright:

"Mississippi State went 12-1 straight-up against non-conference teams this year but did not produce a winning streak longer than two games once getting into the rugged SEC portion of its schedule. Meanwhile, the Bears are 9-3 in NCAA Tournament games since 2020, which is why I am predicting a mild upset."

👉 For more analysis, check out our Mississippi State vs. Baylor prediction.

📊 Mississippi State vs. Baylor odds

🏀 Alabama vs. Robert Morris prediction, 12:40 p.m. ET (truTV)

🎯 Score prediction: Alabama 93, Robert Morris 76
💰 Best Alabama moneyline odds: -5000 via DraftKings

Here's why Mike Spector is picking Alabama to win outright:

"I don’t expect the Colonials to keep the Crimson Tide under their season average, but a pro-Robert Morris crowd should spur the underdogs on playing nearly two hours from campus. That’s why I’m predicting a final score of Alabama 93, Robert Morris 76."

👉 For more analysis, check out our Alabama vs. Robert Morris prediction.

📊 Alabama vs. Robert Morris odds

🏀 Iowa State vs. Lipscomb prediction, 1:30 p.m. ET (TNT)

🎯 Score prediction: Iowa State 74, Lipscomb 66
💰 Best Iowa State moneyline odds: -1111 via Caesars

Here's why Phil Wood is picking Iowa State to win outright:

"The Bisons will stay in this game thanks to their 46th-ranked 3-point shooting. Meanwhile, the Cyclones rank 134th in opponent 3-point shooting percentage. Lipscomb could pull off this upset, but I think it’s more likely they lose a relatively close game that sees Iowa State pull away late."

👉 For more analysis, check out our Iowa State vs. Lipscomb prediction.

📊 Iowa State vs. Lipscomb odds

🏀 Memphis vs. Colorado State prediction, 2 p.m. ET (TBS)

🎯 Score prediction: Colorado State 75, Memphis 69
💰 Best Colorado State moneyline odds: +106 via FanDuel

Here's why Isaiah Sirois is picking Colorado State to win outright:

"It’s tricky to evaluate Memphis since we don’t know the status of multiple key players, but their struggles against Tulane and, at least in the first half, against UAB at the AAC tournament are concerning, especially as they rank outside Bart Torvik’s top 90 since Feb. 1."

👉 For more analysis, check out our Memphis vs. Colorado State prediction.

📊 Memphis vs. Colorado State odds

🏀 Duke vs. Mount St. Mary's prediction, 2:50 p.m. ET (CBS)

🎯 Score prediction: Duke 87, Mount St. Mary’s 52
💰 Best Duke moneyline odds: -10000 via BetMGM

Here's why Mike Spector is picking Duke to win outright:

"Duke had a stretch at the end of the regular season where it beat four straight opponents by 33-plus points, including a No. 6 seed in the NCAA Tournament (Illinois). The Blue Devils have also covered eight of their last 10 games, which is why I’m predicting a final score of Duke 87, Mount St. Mary’s 52."

👉 For more analysis, check out our Duke vs. Mount St. Mary's prediction.

📊 Duke vs. Mount St. Mary's odds

🏀 Saint Mary's vs. Vanderbilt prediction, 3:15 p.m. ET (truTV)

🎯 Score prediction: Saint Mary’s 70, Vanderbilt 65
💰 Best Saint Mary's moneyline odds: -189 via ESPN BET

Here's why Mike Spector is picking Saint Mary's to win outright:

"Vanderbilt is better in the favorite role than as an underdog, going 12-6 ATS as a favorite while covering just six of 14 games as a ‘dog. That’s why I’m predicting a final score of Saint Mary’s 70, Vanderbilt 65."

👉 For more analysis, check out our Saint Mary's vs. Vanderbilt prediction.

📊 Saint Mary's vs. Vanderbilt odds

🏀 Ole Miss vs. North Carolina prediction, 4:05 p.m. ET (TNT)

🎯 Score prediction: Ole Miss 83, North Carolina 78
💰 Best Ole Miss moneyline odds: +116 via FanDuel

Here's why Phil Wood is picking Ole Miss to win outright:

"The Tar Heels played plenty of good teams this season, but they went just 1-12 in Quad 1 games. Five of those 12 losses were by double figures. Meanwhile, the Rebels went 8-10 in Quad 1 games, and they picked up wins over 10 NCAA Tournament teams."

👉 For more analysis, check out our Ole Miss vs. North Carolina prediction.

📊 Ole Miss vs. North Carolina odds

🏀 Maryland vs. Grand Canyon prediction, 4:35 p.m. ET (TBS)

🎯 Score prediction: Maryland 85, Grand Canyon 70
💰 Best Maryland moneyline odds: -556 via Caesars

Here's why Isaiah Sirois is picking Maryland to win outright:

"I think the pace will play a huge factor in this one, as Maryland will get plenty of possessions to prove themselves as the far better team. Grand Canyon’s turnover issues will only feed into that problem. Back the Terps to win big."

👉 For more analysis, check out our Maryland vs. Grand Canyon prediction.

📊 Maryland vs. Grand Canyon odds

🏀 Florida vs. Norfolk State prediction, 6:50 p.m. ET (TNT)

🎯 Score prediction: Florida 88, Norfolk State 65
💰 Best Florida moneyline odds: -9001 via DraftKings

Here's why Isaiah Sirois is picking Florida to win outright:

"Bart Torvik has this game projected at 90-64, so we’re also right around that number. Because games with massive spreads like this one tend to be snoozers, a final score bet might be just what the doctor ordered to get you through this game."

👉 For more analysis, check out our Florida vs. Norfolk State prediction.

📊 Florida vs. Norfolk State odds

🏀 Kentucky vs. Troy prediction, 7:10 p.m. ET (CBS)

🎯 Score prediction: Kentucky 86, Troy 70
💰 Best Kentucky moneyline odds: -714 via Caesars

Here's why Brenden Schaeffer is picking Kentucky to win outright:

"Although Troy’s strength is its defense, the Trojans are unlikely to be able to impose their preferred pace (229th in adjusted tempo) against the run-and-gun Wildcats. Kentucky’s top-10 adjusted offensive efficiency should allow the Wildcats to pile up the points."

👉 For more analysis, check out our Kentucky vs. Troy prediction.

📊 Kentucky vs. Troy odds

🏀 Marquette vs. New Mexico prediction, 7:25 p.m. ET (TBS)

🎯 Score prediction: Marquette 83, New Mexico 81
💰 Best Marquette moneyline odds: -175 via ESPN BET

Here's why Phil Wood is picking Marquette to win outright:

"The Lobos like to play fast, and they are the type of mid-major that can cause headaches for any top-tier conference. Dent will show the nation why he’s one of the best scorers in the country, but he won’t be able to do enough to secure the Lobos’ victory."

👉 For more analysis, check out our Marquette vs. New Mexico prediction.

📊 Marquette vs. New Mexico odds

🏀 Arizona vs. Akron prediction, 7:35 p.m. ET (truTV)

🎯 Score prediction: Arizona 93, Akron 77
💰 Best Arizona moneyline odds: -1111 via Caesars

Here's why Mike Spector is picking Arizona to win outright:

"Akron went 0-2 against NCAA Tournament teams that earned No. 7 and No. 13 seeds (Saint Mary’s and Yale), losing by an average of 17.5 points in those games. That is why I’m predicting a final score of Arizona 93, Akron 77."

👉 For more analysis, check out our Arizona vs. Akron prediction.

📊 Arizona vs. Akron odds

🏀 UConn vs. Oklahoma prediction, 9:25 p.m. ET (TNT)

🎯 Score prediction: UConn 74, Oklahoma 72
💰 Best UConn moneyline odds: -208 via ESPN BET

Here's why Isaiah Sirois is picking UConn to win outright:

"The Huskies are 347th in turnovers and 341st in turnovers forced. To be fair, Oklahoma isn’t that good, either. The Sooners are 49th in T-Rank and neither their offense nor defense sports a top-25 rank in adjusted efficiency."

👉 For more analysis, check out our UConn vs. Oklahoma prediction.

📊 UConn vs. Oklahoma odds

🏀 Illinois vs. Xavier prediction, 9:45 p.m. ET (CBS)

🎯 Score prediction: Illinois 83, Xavier 78
💰 Best Illinois moneyline odds: -154 via ESPN BET

Here's why Brenden Schaeffer is picking Illinois to win outright:

"In their comeback win over Texas, the Musketeers showed a strong ability to pour on points late and should keep it close until the waning moments. But Illinois is too balanced and strong on the glass to let this one slip away."

👉 For more analysis, check out our Illinois vs. Xavier prediction.

📊 Illinois vs. Xavier odds

🏀 Michigan State vs. Bryant prediction, 10 p.m. ET (TBS)

🎯 Score prediction: Michigan State 93, Bryant 64
💰 Best Michigan State moneyline odds: -2000 via BetMGM

Here's why Phil Wood is picking Michigan State to win outright:

"This should be one of the most lopsided games of the first round. The Bulldogs are allowing over 74 points per game, and they played 19 games against the America East. They played two tournament teams, with both scoring at least 99 against their porous defense."

👉 For more analysis, check out our Michigan State vs. Bryant prediction.

📊 Michigan State vs. Bryant odds

🏀 Oregon vs. Liberty prediction, 10:10 p.m. ET (truTV)

🎯 Score prediction: Oregon 77, Liberty 68
💰 Best Oregon moneyline odds: -294 via ESPN BET

Here's why Mike Spector is picking Oregon to win outright:

"The Ducks were dominant in the non-conference portion of their schedule, winning the Players Era Festival with wins over Texas A&M, San Diego State, and Alabama (all NCAA Tournament teams) and wins over two other tournament teams against Troy and Montana."

👉 For more analysis, check out our Oregon vs. Liberty prediction.

📊 Oregon vs. Liberty odds

🏀 Best March Madness odds, predictions & expert picks today

Here are our best March Madness picks for Friday's first-round action:

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Written by:
C Jackson Cowart

C Jackson Cowart is the Senior Publishing Editor at Sportsbook Review, specializing in NFL and NASCAR betting while helping lead the team's coverage of college sports and major events like the Super Bowl and March Madness. In his seven years covering sports betting as a predictive analyst, features writer, and industry reporter, he has stayed true to "process over results" while specifically targeting futures betting and news-driven markets, where he can lean on advanced metrics and an understanding of market psychology to attack value before the number moves. His favorite sportsbook is FanDuel for its clean interface and ease of use, though he finds some of his best value bets at Caesars and bet365, especially for NASCAR. An award-winning writer and editor with a decade of experience in sports media, "C-Jax" has worked with ESPN, Forbes, theScore, and multiple large daily newspapers before joining SBR in 2023. He's a proud graduate of the University of North Carolina, where he covered the Tar Heels' championship run through the 2017 NCAA men's basketball tournament. He's cashed some big tickets over the years — including Lamar Jackson to win MVP (twice) — but he's still haunted by enough second-place slips to wallpaper his home office.

Gonzaga Bulldogs guard Tyon Grant-Foster (7), seen here controlling the ball, is featured in our Oregon State vs. Gonzaga prediction tonight.