March Madness Odds & Schedule Today: Friday's Best Bets & Expert Picks for NCAA Tournament

Last updated: March 21, 2025 10:04 PM EDT • 3 min read X Social Google News Link

There's one 16-game slate left before we advance past the first round of the NCAA Tournament. But with so many games to choose from and options to bet, where do you start? That's where we come in.
We have our March Madness odds and schedule today with our best bets and expert picks for every NCAA Tournament game to guide you through the ups and downs of the second day of action as you try to cope with your already busted bracket.
🗓️ Friday's NCAA Tournament schedule
- No. 2 Michigan State vs. No. 15 Bryant, 10 p.m. ET (TBS), South Region
- No. 5 Oregon vs. No. 12 Liberty, 10:10 p.m. ET (truTV), East Region
🏀 Friday's March Madness expert picks & best bets
No. 2 Michigan State vs. No. 15 Bryant, 10 p.m. ET (TBS), South Region
Expert pick (Philip Wood): Michigan State -17.5 (-105 via FanDuel) vs. Bryant ⭐⭐⭐⭐⭐
- When: Friday, March 21 | 10 p.m. ET
- Where: Rocket Arena (Cleveland)
- How to watch: TBS
- Preview: Michigan State vs. Bryant prediction

No. 5 Oregon vs. No. 12 Liberty, 10:10 p.m. ET (truTV), East Region
Expert pick (Mike Spector): Jackson Shelstad Over 13.5 points (-120 via BetMGM) ⭐⭐⭐⭐⭐
- When: Friday, March 21 | 10:10 p.m. ET
- Where: Climate Pledge Arena (Seattle)
- How to watch: truTV
- Preview: Oregon vs. Liberty prediction
🏀 Best March Madness odds, predictions & expert picks today
Here are our best March Madness picks for Friday's first-round action:
- March Madness odds & schedule today
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💰 March Madness betting odds pages
March Madness odds | March Madness MVP odds |
Women's March Madness odds | March Madness MVP predictions |
Final Four odds | March Madness prop bets |
👑 Best March Madness betting sites
Ready to place your March Madness bets? Check out the best March Madness betting promos from the best March Madness betting sites as determined by our expert team at Sportsbook Review.
- Caesars Promo Code: SBRBONUSDYW | Read our Caesars Review
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- DraftKings Promo Code | Read our DraftKings Review
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Andrew Reid X social