Bucks vs. Cavaliers Odds, Picks, Predictions: Who Will Win Eastern Conference Showdown?

The Milwaukee Bucks face the Cleveland Cavaliers in a compelling clash between Eastern Conference foes. Read on for our top Bucks vs. Cavaliers NBA picks based on the best NBA odds.

Milwaukee (29-16) enters this matchup on a two-game win streak after defeating the Toronto Raptors and Indiana Pacers on back-to-back nights earlier this week. Cleveland (28-19) dropped two in a row to the Memphis Grizzlies and Golden State Warriors, and is eager to face an Eastern Conference squad.

The Cavs, currently fifth in the East, are short home favorites against a Bucks team that sits just behind the Boston Celtics in the conference standings. Who will prevail Saturday night?

Here is our best Bucks vs. Cavaliers NBA pick (odds via DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

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Bucks vs. Cavaliers Game Info

• Date: Saturday, Jan. 21, 7:30 p.m. ET
• TV: NBA League Pass
• Location: Rocket Mortgage FieldHouse, Cleveland, OH

Bucks vs. Celtics Odds

Check out our NBA Finals odds and NBA MVP odds.

Bucks vs. Celtics Odds Analysis

The Cavaliers opened as 2-point favorites, but the line dropped down to 1.5 across most top-rated sportsbooks. Bettors can get slightly favorable juice by taking the Bucks +1.5 at FanDuel, which currently has a -108 vig compared to the standard -110 offering everywhere else.

The total opened at 220 and since climbed up to 221 at most shops. The best place to bet the Under is at PointsBet and BetMGM, the only sportsbooks hanging a 221.5 as of Saturday morning.

Bucks vs. Celtics Pick

Cavaliers -1.5 vs. Bucks (-110 via DraftKings) ⭐⭐⭐

This is a tough game to handicap until we know the status of each team's star players. Bucks power forward Giannis Antetokounmpo is questionable with a knee injury, while Cavs guard Donovan Mitchell is TBD with a groin injury.

Mitchell missed the last two games, but assuming he's back in action tonight, taking the spread with the home team is the right choice. Cleveland is 14-8-1 ATS as a home favorite and has a 13-9-3 ATS clip in conference games. The Bucks are 8-11-3 ATS as the road team this season.

If Giannis does play, Cleveland’s defense did a solid job on him in their first meeting, holding the former MVP to 16 points. He’s done much better in the two contests since, but the Cavs rank an NBA third in points per possession allowed. The Bucks actually rank second. 

In a low-scoring game, take the home team to make the plays down the stretch. This three-star bet is good until 2.5, but consider passing if the spread gets any higher.

Bucks vs. Cavaliers Best Odds

DraftKings (-110)

Four of five top-rated sportsbooks agree on this spread, despite uncertainty on whether Giannis or Mitchell will play. FanDuel is the lone exception, offering a juiced -112 on the 1.5-spread.

FanDuel isn’t the best place for this bet, but it's a sign of things to come for this spread. This line will likely grow if we get better information about Mitchell, who averages 28.4 points per game.

Bucks-Cavaliers pick made 1/21/2022 at 9:54 a.m. ET.

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