Tigers vs. Red Sox Prediction: MLB Odds & Expert Picks for Sept. 26

The Detroit Tigers (86-73) and Boston Red Sox (87-72) will begin a crucial weekend series at 7:10 p.m. on Friday at Fenway Park (Apple TV). Both teams have plenty of motivation as I make my Tigers vs. Red Sox prediction.

Detroit is currently the No. 6 seed in the American League, but it holds the same record as the Cleveland Guardians for the AL Central title and No. 3 spot. The Red Sox sit at No. 5, two games up on the Houston Astros for a postseason berth.

Boston is a short -120 favorite to clinch a playoff spot, which my MLB picks believe is a line worth grabbing before first pitch.

📊 Tigers vs. Red Sox odds

Latest MLB odds updated live in real time.

⚾ Tigers vs. Red Sox predictions

MLB expert picks odds subject to change.

• Game pick: Red Sox ML (-120 via BetMGM) ⭐⭐⭐⭐
• Over/Under pick: Under 8.5 (+100 via FanDuel) ⭐⭐⭐
• Player prop bet: Trevor Story Under 1.5 total bases (-115 via bet365) ⭐⭐⭐⭐

✅ Tigers vs. Red Sox expert pick

Track the latest MLB scores for line movement and matchup info.

🧦 Red Sox ML (-120) ⭐⭐⭐⭐

Left-hander Kyle Harrison (1-1, 3.58 ERA) will make his second start for the Red Sox during Friday’s opener against the Tigers. If it’s anything like his first nod, our best sports betting sites are underrating Harrison.

Harrison, who was the headliner in the return for Rafael Devers on June 15, spent most of the year in Triple-A working on his pitch mix. That hard work might be paying off, as Harrison tossed six innings of one-run ball against the Tampa Bay Rays on Saturday. He did that after adding a cutter and fine-tuning his pitch grips.

A matchup against the Tigers could be a good test to see if Harrison can make a case for the postseason roster. Detroit is second in the league with a wRC+ of 115 against left-handed pitchers, though that mark has dropped to 88 during a 6-15 clip this month while squandering away a division lead.

I’ll side with Harrison and fade Detroit’s recent form in my Tigers vs. Red Sox prediction, potentially earning $8.33 on a $10 bet through BetMGM.

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💰 Tigers vs. Red Sox player prop bet

Our MLB player prop odds tool shows the best odds for every market across legal sportsbooks in your area.

⬇️ Trevor Story Under 1.5 total bases (-115) ⭐⭐⭐⭐

Although I like Boston to win on Friday, it's hard to pass on this price to fade Trevor Story. This same Under costs as much as -140 at DraftKings, meaning the -115 value at bet365 and BetMGM won’t last much longer.

Story has been producing a bounce-back campaign for the Red Sox, generating 4.0 WAR over 155 games after playing 69 contests across his last two years. He’s cleared this prop in three straight outings, but THE BAT X’s model projects 1.77 bases, indicating his streak could end on Friday.

If you're looking for a Boston hitter set to thrive, our Mike Spector is targeting Alex Bregman in his best home run predictions today.

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