Giants vs. Dodgers Prediction, Odds & Expert Picks: MLB Best Bets for Sept. 19
Los Angeles has dominated San Francisco in 10 meetings this season, something I’m expecting to continue as I make my Giants vs. Dodgers prediction.
The Dodgers are a -178 betting favorite ahead of first pitch at 10:10 p.m. ET (Apple TV+) on Friday from Dodger Stadium in Los Angeles.
My MLB picks like Giants slugger Willy Adames in what should be a favorable matchup, and I’m backing the Over on one of his player props.
⚾ Giants vs. Dodgers expert picks & predictions
MLB odds subject to change.
- Moneyline pick: Dodgers (-178 via FanDuel) ⭐⭐
- Run line pick: Dodgers -1.5 (+115 via bet365) ⭐⭐⭐
- Over/Under pick: Over 8.5 (-120 via BetMGM) ⭐⭐
📝 Giants vs. Dodgers preview & best bet
Track the latest MLB scores for line movement and matchup info.
🔥 Dodgers -1.5 (+115) ⭐⭐⭐
The Dodgers are 7-3 in 10 meetings against the Giants in 2025. They just saw Giants starting pitcher Robbie Ray in San Francisco on Sunday, getting to the southpaw for five earned runs on six hits and four walks over just four innings.
Ray has struggled mightily in his last seven starts, registering a 6.06 ERA with 33 strikeouts, 16 walks, and a 1.51 WHIP over 35 2/3 innings. The Dodgers have been swinging hot bats as of late, averaging 6.1 runs per game over the last 10.
I like the Dodgers to rise to the occasion in a game where there should be an added layer of emotion with future Hall of Famer Clayton Kershaw set to make his last start in front of the home fans at Dodger Stadium.
One of the best sports betting sites, bet365, offered +115 odds on the Dodgers -1.5, which nets out a profit of $11.50 on a $10 bet. The +115 odds have an implied probability of 46.51%.
💰 Best Giants vs. Dodgers player prop bet
Our MLB player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
⬆️ Willy Adames Over 1.5 hits, runs, and RBI (+110) ⭐⭐⭐
Willy Adames is two home runs away from becoming the first Giant to hit 30 long balls in a season since Barry Bonds in 2004.
He’s done a decent job of attacking fastballs this season, hitting 20 of his 28 home runs with a .259 average and .491 slugging percentage. That could be a recipe for success against Kershaw’s fastball, which has permitted a .275 batting average with a whiff rate of only 6% in 2025.
A $10 bet on Adames’ Over pays out a profit of $11 at DraftKings. The +110 odds have an implied probability of 47.62%.
📊 Giants vs. Dodgers odds: Sept. 19
MLB odds update live in real time.
📈 Giants vs. Dodgers betting odds analysis
Los Angeles opened as high as a -189 favorite at home, with some of the best sports betting apps offering them as low as -167. I think there’s a strong possibility that the line could move higher in the Dodgers’ direction with the potential boost of Kershaw’s last home outing serving as a motivator.
🔢 Giants vs. Dodgers stats
Season stats courtesy of baseball-reference.com.
| Giants (76-77) | Statistic (per game) | Dodgers (86-67) |
|---|---|---|
| 4.33 | Runs | 5.10 |
| 7.79 | Hits | 8.59 |
| .235 | AVG | .254 |
| .385 | SLG | .439 |
| .696 | OPS | .768 |
| 3.85 | ERA | 4.03 |
| 8.47 | K/9 | 9.26 |
| 3.21 | BB/9 | 3.53 |
| 0.86 | HR/9 | 1.13 |
🚑 Giants vs. Dodgers injuries
📺 Giants vs. Dodgers game info
- When: Friday, Sept. 19
- First pitch: 10:10 p.m. ET
- Where: Dodger Stadium (Los Angeles)
- How to watch: Apple TV+
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❓ Giants vs. Dodgers FAQs
Who is favored to win Giants vs. Dodgers?
The Dodgers are the -179 favorite to defeat the Giants at home on Friday.
What is the run line for Giants vs. Dodgers?
Los Angeles is a -1.5 run line favorite against San Francisco in Friday’s matchup.
What is the Over/Under for Giants vs. Dodgers?
The total for Friday’s game between the Giants and Dodgers is 8.5.
What are the best bets for Giants vs. Dodgers?
My best bets for Friday’s Giants vs. Dodgers game are Los Angeles -1.5 (+115) and Willy Adames Over 1.5 hits, runs, and RBI (+110).
When is the Giants vs. Dodgers game?
First pitch is set for 10:10 p.m. ET on Friday at Dodger Stadium in Los Angeles.
How do baseball odds work?
When betting on MLB, the run line shows how many runs the favorite needs to win by in order to cash the bet. For example, a favorite of -1.5 must win by two or more runs to cover the run line, while an underdog at +1.5 must win outright or lose by one run to cover the run line.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total of runs will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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