College Football Predictions & Odds Week 13: Best Bets for Top Matchups

Check out the latest college football predictions and odds for Week 13, including our best bets and expert picks for all the top matchups.
Oregon's Dante Moore leads the Ducks against USC in the biggest game of our college football predictions for Week 13.
Pictured: Oregon's Dante Moore leads the Ducks against USC in the biggest game of our college football predictions for Week 13. Photo by Ben Lonergan via Imagn Images.

The penultimate week of the regular season might lack a plethora of major matchups, but our college football predictions for Week 13 break down the biggest games on the slate, including what could be a pseudo-College Football Playoff play-in game.

This week, our college football picks cover USC and Oregon's College GameDay matchup, Oklahoma's sneaky tough showdown against Missouri, the Florida vs. Tennessee rivalry game, and much more.


🏈 College football predictions: Week 13

Here are all of our college football expert picks for Week 13, which we'll update throughout the week.

  • Akron vs. Bowling Green player props (coming soon)
  • UMass vs. Ohio player props (coming soon)
  • Western Michigan vs. Northern Illinois player props (coming soon)
  • Miami (OH) vs. Buffalo player props (coming soon)
  • Central Michigan vs. Kent State player props (coming soon)
  • Louisiana vs. Arkansas State player props (coming soon)
    • Louisiana vs. Arkansas state same-game parlay (coming soon)
  • Florida State vs. NC State player props (coming soon)
    • Florida State vs. NC State same-game parlay (coming soon)
  • Hawaii vs. UNLV player props (coming soon)
    • Hawaii vs. UNLV same-game parlay (coming soon)
  • Rutgers vs. Ohio State prediction (coming soon)
  • Early Missouri vs. Oklahoma (coming soon)
    • Missouri vs. Oklahoma player props (coming soon)
  • Early USC vs. Oregon (coming soon)
    • USC vs. Oregon player props (coming soon)
    • USC vs. Oregon same-game parlay (coming soon)
    • USC vs. Oregon anytime touchdown scorer predictions (coming soon)
  • Syracuse vs. Notre Dame player props (coming soon)
    • Syracuse vs. Notre Dame same-game parlay (coming soon)
  • Arkansas vs. Texas player props (coming soon)
  • Tennessee vs. Florida player props (coming soon)
    • Tennessee vs. Florida same-game parlay (coming soon)
  • BYU vs. Cincinnati player props (coming soon)

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💰 College football odds & expert picks: Tuesday

Here are the latest college football odds for every Week 13 game via the best college football betting sites, which update live in real time. 

📊 Akron vs. Bowling Green odds

  • Date: Tuesday, Nov. 18
  • Kickoff: 7 p.m. ET
  • Location: Doyt L. Perry Stadium (Bowling Green, Ohio)
  • How to watch: ESPNU

📊 UMass vs. Ohio odds

  • Date: Tuesday, Nov. 18
  • Kickoff: 7 p.m. ET
  • Location: Peden Stadium (Athens, Ohio)
  • How to watch: CBSSN

📊 Western Michigan vs. Northern Illinois odds

  • Date: Tuesday, Nov. 18
  • Kickoff: 7 p.m. ET
  • Location: Huskie Stadium (Dekalb, Ill.)
  • How to watch: ESPN2

💰 College football odds & expert picks: Wednesday

📊 Miami (OH) vs. Buffalo odds

  • Date: Wednesday, Nov. 19
  • Kickoff: 7 p.m. ET
  • Location: UB Stadium (Buffalo, N.Y.)
  • How to watch: ESPN2

📊 Central Michigan vs. Kent State odds

  • Date: Wednesday, Nov. 19
  • Kickoff: 7 p.m. ET
  • Location: Dix Stadium (Kent, Ohio)
  • How to watch: ESPNU

💰 College football odds & expert picks: Thursday

📊 Louisiana vs. Arkansas State odds

  • Date: Thursday, Nov. 20
  • Kickoff: 7:30 p.m. ET
  • Location: Centennial Bank Stadium (Jonesboro, Ark.)
  • How to watch: ESPN

💰 College football odds & expert picks: Friday

📊 Florida State vs. NC State odds

  • Date: Friday, Nov. 21
  • Kickoff: 8 p.m. ET
  • Location: Stadium (Raleigh, N.C.)
  • How to watch: ESPN

📊 Hawaii vs. UNLV odds

  • Date: Friday, Nov. 21
  • Kickoff: 10:30 p.m. ET
  • Location: Allegiant Stadium (Las Vegas)
  • How to watch: FS1

💰 College football odds & expert picks: Saturday

📊 Rutgers vs. Ohio State odds

  • Date: Saturday, Nov. 22
  • Kickoff: Noon ET
  • Location: Ohio Stadium (Columbus, Ohio)
  • How to watch: FOX

📊 Missouri vs. Oklahoma odds

  • Date: Saturday, Nov. 22
  • Kickoff: Noon ET
  • Location: Memorial Stadium (Norman, Okla.)
  • How to watch: ABC

🔮 Missouri vs. Oklahoma early prediction

⬇️ Under 43.5 (-12)

After a massive win over Alabama, Oklahoma is positioned to make a College Football Playoff push, something Missouri was hoping to do too prior to losing QB Beau Pribula for the season. With the Tigers starting freshman Matt Zollers and leaning on their run game, led by Ahmad Hardy, scoring won't be easy for Missouri against a defense ranked No. 5 by SP+. But the Sooners' offense hasn't looked all that hot either, and John Mateer might have a hard time getting in a rhythm against an underrated Tigers defense (No. 16 by SP+) with a vicious front seven.


📊 USC vs. Oregon odds

  • Date: Saturday, Nov. 22
  • Kickoff: 3:30 p.m. ET
  • Location: Autzen Stadium (Eugene, Ore.)
  • How to watch: CBS

🔮 USC vs. Oregon early prediction

🦆 Oregon -7.5 (-110)

This is one of the biggest games of the season, with the winner essentially punching its ticket to the CFP and the loser likely headed for a bowl game with a goofy sponsorship name. However, this old Pac-12 rivalry shouldn't live up to the hype with the way USC has played against quality opponents. Lincoln Riley's offense is electric, but the Trojans have gone 3-5 ATS against Power Four opponents. Meanwhile, Dan Lanning has Oregon ranked No. 4 by SP+, with an offense capable of exposing USC's lackluster defense, thanks to Dante Moore, and a defense set to be one of the Trojans' toughest matchups. 


📊 Syracuse vs. Notre Dame odds

  • Date: Saturday, Nov. 22
  • Kickoff: 3:30 p.m. ET
  • Location: Notre Dame Stadium (Notre Dame, Ind.)
  • How to watch: NBC, Peacock

📊 Arkansas vs. Texas odds

  • Date: Saturday, Nov. 22
  • Kickoff: 3:30 p.m. ET
  • Location: DKR-Texas Memorial Stadium (Austin, Texas)
  • How to watch: ABC

🔮 Arkansas vs. Texas early prediction

🐂 Texas -9.5 (-122)

Since Arkansas fired Sam Pittman, interim head coach Bobby Petrino has gone 0-5 ... completely wrecking his shot at getting the full-time job. The Razorbacks should add another L to his record when they take on a Texas team that can't beat the elite teams in the SEC, but can certainly pad its stats against the bottom dwellers. Arch Manning has looked far more competent and recent weeks and should be able to pick apart an Arkansas team ranked No. 88 by defensive SP+. And while Taylen Green has been electric for the Razorbacks, this Texas defense is one of the best in the country. Arkansas is just 3-5 ATS since Week 3.


📊 Tennessee vs. Florida odds

  • Date: Saturday, Nov. 22
  • Kickoff: 7:30 p.m. ET
  • Location: Ben Hill Griffin Stadium (Gainesville, Fla.)
  • How to watch: ABC

🔮 Tennessee vs. Florida early prediction

🍊 Tennessee -3.5 (+100)

Our best college football betting sites aren't giving Tennessee enough respect with this spread. Are the Volunteers having a down year because of poor defense? Yes, but their three losses have come at the hands of three teams in position to make the CFP (Oklahoma, Alabama, Georgia). Florida, on the other hand, lost by 31 to Kentucky just two weeks ago. Even if DJ Lagway can take advantage of the Vols' defensive problems, I don't see him keeping up with Joey Aguilar and Co. Tennessee is ranked No. 5 on offense by SP+, while Florida is No. 71. The Gators are 2-6-1 ATS against FBS teams this season.


📊 BYU vs. Cincinnati odds

  • Date: Saturday, Nov. 22
  • Kickoff: 8 p.m. ET
  • Location: Nippert Stadium (Cincinnati)
  • How to watch: FOX

💡 College football expert picks: Week 13

  • College football picks against the spread Week 13 (coming soon)
  • College football picks for every top 25 game in Week 13 (coming soon)
  • College football player props Week 13 (coming soon)
  • College football anytime touchdown scorer predictions Week 13 (coming soon)
  • Heisman Trophy power rankings Week 13 (coming soon)
  • College football best bets Week 13 (coming soon)

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