College Football Predictions & Odds for Saturday: Expert Picks for Best Games

Our college football predictions and odds for Saturday highlight the biggest games that the Week 2 slate has to offer.

We make college football picks for the marquee matchups involving ranked teams, including Iowa vs. Iowa State and Michigan vs. Oklahoma, and offer up best bets. Our college football predictions for Week 2 take a more comprehensive look at the weekend's NCAA action through expert picks.

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🏈 Best college football predictions for Saturday

We've compiled the best bets from our college football experts from throughout the week; odds subject to change.

• Iowa-Iowa State Under 41.5 (-108 via DraftKings) ⭐⭐⭐⭐
• Illinois-Duke Under 49.5 (-110 via Caesars) ⭐⭐⭐⭐
• SMU -2.5 (-110 via FanDuel) vs. Baylor ⭐⭐⭐
• Ole Miss -8.5 (-110 via FanDuel) vs. Kentucky ⭐⭐⭐⭐⭐
• Oklahoma State-Oregon Under 55.5 (-105 via BetMGM) ⭐⭐⭐
• South Florida-Florida Over 56 (-110 via bet365) ⭐⭐⭐⭐
• Oklahoma -4.5 (-115 via DraftKings) vs. Michigan ⭐⭐⭐⭐⭐
• Arizona State -6.5 (-110 via ESPN BET) vs. Mississippi State ⭐⭐⭐⭐

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💰 College football odds & expert picks for Week 2

College football odds update live in real time.

📊 Iowa vs. Iowa State odds

• Date: Saturday, Sept. 6
• Kickoff: Noon ET
• Location: Jack Trice Stadium (Ames, Iowa)
• How to watch: ESPN

🔮 Iowa vs. Iowa State prediction

Here's an excerpt from our Iowa vs. Iowa State prediction on why Matt Jacob picks Iowa-Iowa State to finish Under on Saturday:

"How low can they go? That’s been the theme of the Iowa-Iowa State rivalry in recent years. In fact, the victor has scored more than 20 points just once in the six head-to-head battles, that being Iowa’s 27-17 road victory in 2021 - the only matchup since 2018 to clear 40 combined points."

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📊 Illinois vs. Duke odds

• Date: Saturday, Sept. 6
• Kickoff: Noon ET
• Location: Wallace Wade Stadium (Durham, N.C.)
• How to watch: ESPN

🔮 Illinois vs. Duke prediction

Here's an excerpt from my college football betting trends on why I pick Illinois-Duke to finish Under on Saturday:

"Both Duke and Illinois have seasoned secondaries that will lead to the ground attacks featuring heavily in the game narrative. I wasn't convinced by what I saw from the Blue Devils in their Week 1 game. I'm also not certain the Fighting Illini's big-play abilities will translate when playing an FBS opponent after averaging 26.9 points per game last season (64th in FBS)."

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📊 Baylor vs. SMU odds

• Date: Saturday, Sept. 6
• Kickoff: Noon ET
• Location: Gerald J. Ford Stadium (Dallas)
• How to watch: The CW

🔮 Baylor vs. SMU prediction

Here's an excerpt from my college football betting trends on why I pick SMU to cover the spread against Baylor on Saturday:

"I don't like the way Baylor struggled against a mobile quarterback in Jackson Arnold during a Week 1 loss to Auburn. Thus, I'll take a flier on the Mustangs to end the streak and pick up a historic victory at home with a convincing win over the Bears."

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📊 Ole Miss vs. Kentucky odds

• Date: Saturday, Sept. 6
• Kickoff: 3:30 p.m. ET
• Location: Kroger Field (Lexington, Ky.)
• How to watch: ABC

🔮 Ole Miss vs. Kentucky prediction

Here's an excerpt from our college football picks on why Brenden Schaeffer picks Ole Miss to cover the spread against Kentucky on Saturday:

"Ole Miss dropped 695 yards of total offense on Georgia State, which tells me the Rebels may send Kentucky’s defense reeling as retribution for the Wildcats’ upset win in Oxford last fall."

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📊 Oklahoma State vs. Oregon odds

• Date: Saturday, Sept. 6
• Kickoff: 3:30 p.m. ET
• Location: Autzen Stadium (Eugene, Ore.)
• How to watch: CBS

🔮 Oklahoma State vs. Oregon prediction

Here's an excerpt from our Oklahoma State vs. Oregon prediction on why Isaiah Sirois picks Oklahoma State-Oregon to play to Under on Saturday:

"It’s unclear whether the Ducks will even want to reach the 42 they [likely] need to score to push this one Over. Head coach Dan Lanning may opt for a more conservative, slow-paced game script after his Ducks get out to an early lead, especially against an injury-riddled team captained by a legend of the sport in head coach Mike Gundy."

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📊 South Florida vs. Florida odds

• Date: Saturday, Sept. 6
• Kickoff: 4:15 p.m. ET
• Location: Ben Hill Griffin Stadium (Gainesville, Fla.)
• How to watch: SEC Network

🔮 South Florida vs. Florida prediction

Here's an excerpt from my college football betting trends on why I pick South Florida-Florida to finish Over on Saturday:

"I need a bigger sample size from both squads before deciding how to play the spread, so I simply won't in Week 2. Instead, I'll play the lowest total in a meeting between the two this decade and back them to remain perfect toward the Over in their rivalry's short history."

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📊 Michigan vs. Oklahoma odds

• Date: Saturday, Sept. 6
• Kickoff: 7:30 p.m. ET
• Location: OU Memorial Stadium (Norman, Okla.)
• How to watch: ABC

🔮 Michigan vs. Oklahoma prediction

Here's an excerpt from our college football picks on why Matt Jacob picks Oklahoma to cover the spread against Michigan on Saturday:

"Michigan true freshman quarterback Bryce Underwood was solid in his debut. But that was in the Big House. Let’s see how he handles the crazy atmosphere that awaits in Norman. Moreover, let’s see how Michigan’s defense holds up against a quarterback who is vastly superior to the one they faced a week ago: Oklahoma’s John Mateer."

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📊 Arizona State vs. Mississippi State odds

• Date: Saturday, Sept. 6
• Kickoff: 7:30 p.m. ET
• Location: Davis Wade Stadium (Starkville, Miss.)
• How to watch: ESPN2

🔮 Arizona State vs. Mississippi State prediction

Here's an excerpt from our college football picks on why Rob Paul picks Arizona State to cover the spread against Mississippi State on Saturday:

"Mississippi State struggled with a Southern Miss squad that predominantly relied on transfers in Week 1. The Bulldogs' defense, No. 78 in SP+, is going to have an impossible time slowing down Sam Leavitt and Jordyn Tyson, who have the Sun Devils ranked No. 30 in SP+."

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❓ College football betting FAQs

How do college football spread odds work?

When betting on college football, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.

How do college football moneyline odds work?

When betting on college football, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.

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