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South Carolina Gamecocks quarterback LaNorris Sellers rushes against the Kentucky Wildcats.
South Carolina Gamecocks quarterback LaNorris Sellers rushes against the Kentucky Wildcats. Photo by Jeff Blake via Imagn Images Kentucky.

An SEC showdown takes over College GameDay on Saturday, as the LSU Tigers square off against the South Carolina Gamecocks in Columbia, S.C.

No. 16 LSU may only be a middle-of-the-road contender by the SEC championship odds, but it serves as a touchdown favorite in this affair despite playing on the road. However, Brian Kelly's team has been vulnerable in its first two games.

For its part, South Carolina pulled off a big road upset against Kentucky, and this could serve as another statement game - this time coming in front of a national audience.

As part of our college football Week 3 predictions, we question whether South Carolina can do enough to keep this close against LSU.

Best LSU vs. South Carolina picks

College football picks based on the odds from our best college football betting sites. Odds subject to change.

  • Against the spread pick: South Carolina +7 (-110 via BetMGM) vs. LSU ⭐⭐⭐
  • Player prop pick: LaNorris Sellers Over 176.5 yards (-117 via Caesars) ⭐⭐⭐⭐⭐

South Carolina to cover the spread: +7 (-110 via BeMGM) ⭐⭐⭐

LSU vs. South Carolina opening odds:

The spread hasn’t moved at BetMGM, but DraftKings was hanging a line as high as 10 in the lookahead market. That’s a sign South Carolina is likely the correct side, especially in this matchup.

Mike Spector certainly agrees with that thinking in his college football upset picks.

Nuss bus on the road

Despite having the burden of replacing a Heisman winner, LSU quarterback Garrett Nussmeier, who's now a Heisman odds long shot himself, has been the team’s best player through two weeks. He's thrown for 610 yards and eight touchdowns.

But this will be his first start on the road, and South Carolina’s defense is equipped to give him a test. The Gamecocks rank third in the country in EPA per dropback allowed, posting the sixth-best coverage grade in college football, according to Pro Football Focus.

LSU’s offense has become one-dimensional since losing running back John Emery Jr., which is why Nussmeier threw 37 times against Nicholls last week. South Carolina’s defense will be ready to take advantage of that approach.

Sellers statement

The surface stats don’t look too impressive for South Carolina freshman quarterback LaNorris Sellers. He's 20-for-37 for 280 yards and two touchdowns through the air, all while adding 57 yards on 30 rushing attempts.

But he's flashed his big-play ability, highlighting his potential as a collegiate signal-caller. Sellers has registered a 92.8 passing grade on 10-plus yard throws, according to PFF. That bodes well against a shaky LSU defense that's allowed 48 points through two weeks.

If Sellers can make a big play at home, that could go a long way toward aiding South Carolina’s upset bid.

Best odds: -110 via BetMGM | Implied probability: 52.38%

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LSU vs. South Carolina prop pick for Week 3

Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

LaNorris Sellers Over 176.5 passing yards (-117) ⭐⭐⭐⭐⭐

Sometimes betting doesn’t have to be too complicated. FanDuel, one of the sharper prop betting sites among our best sportsbooks, is trading Sellers’ passing prop at 184.5. As such, Caesars is offering bettors a discount with this line.

This play is a five-star pick because there are multiple ways to get the Over to the window. South Carolina needs a strong game from Sellers to pull off an upset, but he could also clear this mark if the team needs to play from behind. 

Either way, Sellers should excel against an LSU pass defense that ranks 126th in yards per dropback allowed. With a projection north of 200 yards, this Over comes with plenty of value.

Best odds: -117 via Caesars | Implied probability: 53.92%

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LSU vs. South Carolina odds

See all of this week's college football odds and NCAAF scores.

LSU vs. South Carolina game info

  • When: Saturday, Sept. 14
  • Kickoff: Noon
  • Where: Williams-Brice Stadium, Columbia, SC
  • How to watch: ESPN
  • Weather: 76 degrees, 25% chance of precipitation, 9 mph winds
  • Favorite: LSU -7 (-110 via BetMGM)

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