LSU vs. Clemson Prediction, Odds & Expert Picks Tonight: College Football Week 1 Best Bets
My LSU vs. Clemson prediction looks at the game from a betting lens as a pair of AP top 10 ranked Tigers squads tussle tonight. Kickoff from Memorial Stadium in Clemson, S.C., is set for 7:30 p.m. ET (ABC).
No. 4 Clemson is trading as a 3.5 to 4.5-point betting favorite, but my college football picks point out a few reasons that No. 9 LSU is a value play. As part of my college football predictions for Week 1, I have my favorite LSU vs. Clemson player prop trading at nearly 3-1.
🏈 LSU vs. Clemson expert picks & predictions
College football expert picks made Friday; odds subject to change.
- Moneyline pick: LSU (+158 via Caesars) ⭐⭐⭐
- Against the spread pick: LSU +4.5 (-114 via FanDuel) ⭐⭐⭐⭐
- Over/Under pick: Over 57.5 (-110 via Caesars) ⭐⭐⭐
📝 LSU vs. Clemson preview & best bet
Track the latest college football scores for line movement and matchup info.
🐯 LSU +4.5 (-114) ⭐⭐⭐⭐
Clemson and LSU are incredibly similar. They both come into the 2025 season with sky-high expectations behind Heisman Trophy odds favorites under center, questionable offensive lines, and servicable - but spotty - defenses.
The hosts are the popular pick for two reasons: roster continuity (No. 1 in returning production) and consistency. The Bayou Bengals have lost five straight season openers, including the last two under Brian Kelly. However, Dabo Swinney-coached teams have been just as bad in other ways.
A College Football Playoff appearance made everyone forget about Clemson's embarrassing loss in last year's season opener against Georgia. The Bulldogs beat up on the Tigers 34-3, so if that was the case, what's stopping a more talented LSU offense from lighting up the scoreboard?
LSU boasts a significantly higher blue-chip percentage (73%) than Clemson (55%) after adding a top-10 recruiting class and the top-ranked transfer class in the offseason. While I'm not predicting a blowout win for the visitors, I do expect them to keep pace with Cade Klubnik and Co.
This is the best value that the best college football betting sites have offered all week, so grab LSU +4.5 at FanDuel. A $10 ticket with the shop yields an $8.77 return in profits.
Bet $5, Win $300 in Bonus Bets
New customers only. Min. first deposit and wager of $5+. Bonus bets are awarded within 72 hours of winning your first wager. T&Cs apply.
Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
💰 Best LSU vs. Clemson player prop bet
Check out our guide to college player prop betting by state to see where college football player props are legal.
🔥 Trey'Dez Green anytime touchdown scorer (+295) ⭐⭐⭐⭐
LSU dual-sport athlete Trey'Dez Green has the potential to become college football's most dominant player that you've probably never heard of before now. The 6-foot-7, 240-pound tight end showed flashes of his skill set when stepping in as the starter for Mason Taylor in the Tigers' bowl game last season.
Green finished with a relatively unimpressive six catches for 53 yards in the 44-31 victory over Baylor, but 33% of those receptions went for touchdowns. The combination of his size and athleticism makes him nearly unguardable in the red zone.
While Garrett Nussmeier will have a plethora of pacey players to pick from when dropping back, expect Green to be one of his top targets when the field gets shorter. The sophomore is trading at +295 with DraftKings to score a touchdown in Week 1, significantly better than the +210 return at FanDuel.
Our Philip Wood also has a full slate of LSU vs. Clemson player props to feast on for this star-studded showdown.
Bet $5, Get $300 in Bonus Bets + Over $200 Off NFL Sunday Ticket
21+ and present in most states. (18+ DC/KY/NH/WY). Void in OR/NH. 1 per customer. $5+ first-time bet req. Get promo code to redeem NFL Sunday Ticket sub and max. $300 issued as non-withdrawable bonus bets; 7 day expiry.
Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
📊 LSU vs. Clemson odds: Week 1
College football odds update live in real time.
📈 LSU vs. Clemson betting odds analysis
The LSU-Clemson line opened at Clemson -3 back in June. Early money rolled in on the hosts and moved them off the key number, and they are now trading between 3.5 and 4.5 as of Saturday morning, although wagers are now split evenly 50/50.
The popular book has seen 53% of spread tickets and 66% of moneyline tickets back Dabo Swinney's squad, providing even more value for those looking to bet on Brian Kelly's boys. I cannot imagine sharps will allow this line to reach Clemson -5, but stranger things have happened in the world of sports betting before.
🔢 LSU vs. Clemson stats
Season stats courtesy of sports-reference.com.
| LSU (9-4) | Statistic (per game) | Clemson (10-4) |
|---|---|---|
| 30.5 | Points | 34.7 |
| 24.3 | Points allowed | 23.4 |
| -3 | Turnover margin | +16 |
| 315.2 | Passing yards | 278.5 |
| 116.4 | Rushing yards | 173.4 |
| 224.3 | Passing yards allowed | 213.5 |
| 140.1 | Rushing yards allowed | 160.6 |
| +0.3 | Net yards per play | +0.8 |
🚑 LSU vs. Clemson injuries
📺 LSU vs. Clemson game info
- When: Saturday, Aug. 30
- Kickoff: 7:30 p.m. ET
- Where: Memorial Stadium (Clemson, S.C.)
- How to watch: ABC
❓ LSU vs. Clemson FAQs
Who is favored to win LSU vs. Clemson?
Clemson is a -182 betting favorite to beat LSU in Week 1.
What is the spread for LSU vs. Clemson?
Clemson is a 4.5-point betting favorite over LSU in the season opener for both teams.
What is the Over/Under for LSU vs. Clemson?
The total for LSU vs. Clemson is set at 57.5 points.
What are the best bets for LSU vs. Clemson?
My best bets for LSU vs. Clemson are LSU +4.5 and Trey'Dez Green anytime touchdown scorer.
When is the LSU vs. Clemson game?
LSU vs. Clemson kicks off at 7:30 p.m. ET (ABC) from Memorial Stadium in Clemson, S.C.
How do college football odds work?
When betting on college football, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.
Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
Related Articles
