Skip to main content
Lionel Messi dribbles the ball between Joaquín Sosa and Samuel Piette of CF Montréal as we make our best Lionel Messi and game predictions for the May 15 clash featuring Orlando City SC and Inter Miami.
Lionel Messi dribbles the ball between Joaquín Sosa and Samuel Piette of CF Montréal during the second half at Saputo Stadium on May 11, 2024 in Montreal, Quebec. Photo by Minas Panagiotakis/Getty Images via AFP.

On Wednesday, Inter Miami invades Orlando to face state rivals Orlando City SC, as we offer our Lionel Messi pick and Orlando City SC-Inter Miami predictions for the showcase MLS matchup based on the odds from our best sports betting sites.

As expected by soccer enthusiasts worldwide, Lionel Messi and his former Barcelona teammates are making waves in the MLS. Inter Miami (8-2-3) are heavily favored for Wednesday's showdown against Orlando City SC (3-5-3), according to our best sports betting sites. The match kicks off at 7:30 p.m. ET at Inter&Co Stadium in sunny Orlando, Fla.

Currently leading the MLS standings, Messi's squad has secured victory in their last five consecutive games. In contrast, Orlando has faced difficulties, failing to secure a win in their past three home matches. With Messi's recent stellar performance, including seven assists and three goals, Orlando faces a daunting challenge as they square off against their in-state rivals.

Here are our best Orlando City SC vs. Inter Miami predictions for Wednesday's matchup, along with our top soccer picks (odds via our best soccer betting sites; pick confidence based on a 1-to-5-star scale).

Orlando City SC vs. Inter Miami prediction

Inter Miami ML ⭐⭐⭐⭐

Winning five on the bounce, the Herons enter Wednesday's match against their in-state rivals rounding into top form. Inter Miami is the Eastern Conference's second-best road team, taking 13 from a possible 16 points and scoring 14 goals in six games. 

Meanwhile, Orlando City SC has won just three of 10 league matches and finds themselves on the outside of the playoff picture. Orlando has the Eastern Conference's fourth-worst home record, winning one of six encounters.

Inter Miami rolls into Orlando with few personnel concerns. Messi, Luis Suarez, and new signing Matias Rojas are fit, while Diego Gomez remains sidelined. Jordi Alba missed the game against Montreal, but he may be utilized off the bench.

Inter Miami has more firepower than the US Navy, so expect the Herons to deploy it indiscriminately in what should be their sixth win in a row. FanDuel offers the best odds for a Herons' win, a tasty plus-money +155. The implied probability is 39.22%, and a winning $10 bet pays a profit of $15.50. 

Best odds: +155 via FanDuel

Not intended for use in MA
Affiliate Disclosure: Sportsbook Review may receive advertising commissions for visits to a sportsbook

Bet $5, Win $150 in Bonus Bets

New customers only. Deposit min. $10. Place first bet of $5+ and get $150 in Bonus Bets if the bet wins (within 72 hours).

Sportsbook Review may receive advertising commissions for visits to a sportsbook betting site. 21+. Gambling can be addictive, please play responsibly

Lionel Messi anytime goal odds

DraftKingsFanDuelBetMGMCaesarsbet365
+100-110+100-115+110

Lionel Messi prediction

There is a better Messi prop, which focuses on him notching at least one assist. However, FanDuel is the only one of our best sportsbooks offering it. If you can, lock in Messi to get at least one assist, which FanDuel offers at a mouthwatering price of +135. 

As the assists market isn't available at most sportsbooks, I'll turn my attention to Messi bulging the old onion bag. He didn't score against Montreal but potted three in the previous two encounters. Despite starting just eight games, Messi has 10 goals, one behind three players tied atop the goalscorers chart.

Messi scored a brace the last time these two teams met, a 5-0 Inter Miami home victory on March 2. The +110 odds offered by bet365 imply a 47.62% probability that he'll do it again, and a $10 winning bet pays a profit of $11.

Best odds: +110 via bet365

Bet $5, Get $150 in Bonus Bets

Gambling problem? Call 1-800-GAMBLER

Sportsbook Review may receive advertising commissions for visits to a sportsbook betting site. 21+. Gambling can be addictive, please play responsibly

Luis Suarez prediction

Suarez to score is another exceptional bet. The Uruguayan has 11 goals in nine starts and is tied atop the MLS goalscorers chart. He scored five goals in the last three games, including a hat trick at home against the New York Red Bulls.

Like Messi, Suarez scored two goals the last time he faced Orlando. While the former Barcelona frontman should get a few dangerous scoring opportunities, he'll only require one. 

At +125, DraftKings and BetMGM offer the best value. Those odds come with an implied probability of 44.44%, and a $10 winning bet pays a profit of $12.50. 

Best odds: +125 via DraftKings

No Sweat Bet Up To $1,500

+ No Sweat SGP Every Day of NBA Playoffs 🏀

Sportsbook Review may receive advertising commissions for visits to a sportsbook betting site. 21+. Gambling can be addictive, please play responsibly

Orlando City SC vs. Inter Miami game info

  • Date: Wednesday, May 15, 7:30 p.m. ET
  • TV: Apple TV
  • Location: Inter&Co Stadium, Orlando, Fla.
  • Weather: 82 Fahrenheit, sunny
  • Favorite: Inter Miami (+140 via DraftKings)

Orlando City SC vs. Inter Miami odds

(Odds via DraftKings)

TeamsMoneylineSpreadTotal
Inter Miami +140-0.5 (+135)Over 3.5 (+125)
Orlando City SC+155+0.5 (-190)Under 3.5 (-155)

See all of our MLS odds.

Orlando City SC vs. Inter Miami prediction made Tuesday at 12:30 p.m. ET.

Here are our best soccer betting sites:

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Related pages