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Kansas City Chiefs quarterback Patrick Mahomes (15) looks as we offer our best Chiefs vs. Jaguars prediction and odds for Saturday's NFL preseason Week 1 matchup at EverBank Stadium in Jacksonville.
Kansas City Chiefs quarterback Patrick Mahomes looks over the line during training camp. Photo by Denny Medley / USA TODAY Sports via Imagn.

The Super Bowl odds favorites open their exhibition slate as slight underdogs for their NFL preseason Week 1 opener, as we offer our best Chiefs vs. Jaguars prediction and odds for Saturday's 7 p.m. ET kickoff from EverBank Stadium.

Jacksonville is a 1-point favorite over the Chiefs across our best sports betting sites, and both sides are expected to roll out their starters for the first quarter on Saturday.

Bet on hot start from Chiefs vs. Jaguars

Odds via our best NFL betting sitesNFL picks confidence based on a 1-to-5-star scale.

Prediction: Chiefs 1H moneyline (+100) ⭐⭐⭐

As we laid out in our NFL preseason betting guide, it's hard to have too much confidence when betting on exhibition football. But when you find a spot worth betting into, there's value to be found across our best sportsbooks.

That's the case with this first-half bet on Saturday. Chiefs head coach Andy Reid has already publicly stated he'll play his starters for the first quarter before turning to the second unit and that he'll "play everybody" - which should include quarterback Patrick Mahomes and tight end Travis Kelce.

Jaguars coach Doug Pederson has said he'll do the same, in part to match what the Chiefs are planning to do. So why, exactly, are the defending champions catching even money in the first half when they'll be rolling out their first unit for the first 15 minutes?

Market sleeping on Chiefs

We aren't the only ones to catch onto this seemingly mispriced line. Some of our best sports betting apps have Kansas City as a full-game underdog but a favorite in the first quarter or first half - presumably a nod to the Chiefs' plan to play their starters.

Others, like Betway, have the reigning champs as underdogs in the first half. Even with the uncertainty of the second quarter, I still trust the starters more in the first quarter and can stomach some volatility in the second given these +100 odds, which pay out $1 on a winning ticket for every dollar wagered.

While you can never be too sure in the preseason, I'm expecting an early score from the best offense in the league - one that added speedsters Hollywood Brown and Xavier Worthy for this season. You have to expect Mahomes will try to air it out to one of those two in the early going, which could be all we need to cash this preseason bet.

Best odds: +100 via Betway | Implied probability: 50%

Up To $250 First Bet Reset

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Players to watch

Career statsPatrick Mahomes (KC)Trevor Lawrence (JAX)
Preseason1,111 yards, 9 TD, 2 INT (13 starts)679 yards, 4 TD, 1 INT (7 starts)
Regular season28,424 yards, 219 TD, 63 INT (96 starts)11,770 yards, 58 TD, 39 INT (50 starts)

Chiefs vs. Jaguars odds

See our full NFL odds here.

Chiefs vs. Jaguars game info

  • When: Saturday, Aug. 10
  • Kick off: 7 p.m. ET
  • Where: EverBank Stadium
  • How to watch: NFL Network
  • Favorite: Jaguars -1 (-110 via Caesars)
$1,000 First Bet on Caesars

Terms and conditions apply.

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission. 21+. Gambling can be addictive, please play responsibly

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