Exclusive: Trade $25, Get $35 in Bonus Funds CODE: SBR35

Browns vs. Buccaneers Prediction: Week 2 Odds, Picks & Best Bet

Our Browns vs. Buccaneers prediction for Week 2 includes our best bet, projected score, and the latest odds for Sunday's matchup.

Matt MacKay

Last Updated: September 19, 2026 2:30 PM EDT • 3 minute read

Pictured: Tampa Bay Buccaneers quarterback Baker Mayfield (6) drops back to throw as he is featured in our Browns vs. Buccaneers prediction. Photo by Sam Greene/The Enquirer / USA TODAY NETWORK via Imagn Images

Enjoying SBR content? Add us as a preferred source on your Google account

A pair of winless teams will take the field, although one offense holds a massive edge in my Browns vs. Buccaneers prediction. Baker Mayfield makes his home debut this week, while Deshaun Watson and the Browns' offense will search for any meaningful production after an abysmal Week 1 performance.

Catch this game's opening kickoff at 1 p.m. ET from Raymond James Stadium in Tampa, Fla. (CBS). The Buccaneers enter this game as 7.5-point betting favorites against the Browns.

🏈 Browns vs. Buccaneers picks & predictions

See all of our experts' NFL picks for Week 2 based on the latest NFL odds.

Pick	Bet size
Buccaneers -7.5 (-115 via FanDuel)	2.30 units
Over 40.5 (-122 via FanDuel)	1.22 units

Total wagered: 3.52 units | Max profit: +3.00 units

💰 Browns vs. Buccaneers prediction & best bet

Check out all of our NFL picks for more analysis across this week's slate.

Buccaneers -7.5 (-115 via FanDuel)

Mayfield and the Buccaneers tried to rally against the Bengals last week, but falling into a 21-3 deficit and allowing 21 unanswered points proved to be too much. That won't be the case in Week 2, as the Browns only mustered 185 net passing yards from Watson against the Jaguars in Week 1.

Cleveland committed 11 penalties, 2 turnovers, and gave up 5 sacks. Watson's wide receiving corps outside of Jerry Jeudy is extremely raw and young. The entire offense will have growing pains, especially under a new coaching regime led by a defensive-minded head coach in Todd Monken.

The Buccaneers' skilled players are leagues better under a proven OC like Zac Robinson. RB Bucky Irving, veteran wideout Chris Godwin, and talented second and third-year wideouts Emeka Egbuka and Jalen McMillan offer enough talent for Mayfield to stay hyper-productive.

The Browns gave up 245 passing yards and 4 touchdowns to Trevor Lawrence last week. He only threw 5 incompletions and had no turnovers. Mayfield should have a nuclear outing in a Week 2 bounce-back spot.

📡 SBR Edge: Browns Can't Cover

The Browns have failed to cover the point spread in 10 consecutive games.

Sunshine State woes continue for the Browns

This Florida trip will be one to forget for the Cleveland Browns. Mayfield's a highly productive passer and playmaker, and now he faces a defense that no longer has Myles Garrett coming off the edge.

Despite a Week 1 loss, Mayfield finished 23-of-28 for 216 yards and zero interceptions against Cincinnati. The Buccaneers lost 4 fumbles, which is an outlier that won't happen against the Browns. Mayfield's scrambling ability makes him tough to cover, using his legs to find the end zone or extend plays to force broken coverage downfield.

Score prediction: Buccaneers 44, Browns 17

📊 Browns vs. Buccaneers odds

See the latest NFL odds for every Week 2 matchup.

Browns vs. Buccaneers opening odds

Moneyline: Browns +310 | Buccaneers -395
Spread: Browns +6.5 (+100) | Buccaneers -6.5 (-120)
Over/Under: Over 40.5 (-118) | Under 40.5 (-102)

📺 How to watch Browns vs. Buccaneers: Week 2

Date: Sunday, Sept. 20
Kickoff: 1:00 p.m. ET
Location: Raymond James Stadium (Tampa, Fla.)
TV: CBS

📃 Affiliate disclosure

Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)

Written by:
Matt MacKay

Matt MacKay has handicapped golf, the NFL, NCAAF, and NHL since joining the sports betting industry as a writer in 2020. He’s worked for several prominent sites, recently expanding his coverage to include sports betting news and the regulatory industry. Bringing a background in communications and writing, earning a Masters Degree in Organizational Communication from Ohio University, Matt has co-hosted a fantasy football and sports betting podcast, while continuously refining his handicapping methods. This includes identifying recent trends, head-to-head statistics, and comparing individual and team strengths and weaknesses to accurately predict the outcome in certain betting markets before a game or event. He’s a daily bettor and tends to wager on FanDuel, with DraftKings and Hard Rock Bet as preferred sports betting app alternatives. An avid researcher, writer, editor, and podcaster, Matt is eager to dig into matchups to offer readers and subscribers value on his picks. He’s a big proponent of building bankroll by avoiding poor betting habits and tendencies, like chasing losses, placing too many wagers, and managing bankroll. His worst beats to date both came on two separate NFL parlays, losing due to Tyreek Hill and A.J. Brown dropping passes. NRFIs have quickly become one of Matt’s favorite betting markets, recently diving into MLB game props.