Memphis vs. Iowa State Prediction: College Basketball Picks & Odds (Nov. 2)
Last Updated: November 2, 2026 3:47 AM EST • 3 minute read X Social Google News Link
No. 18 Iowa State begins the season against Memphis while looking to replicate last year’s 16-0 start that was the best in school history, and my Memphis vs. Iowa State prediction backs the Cyclones to cover given their more intact roster and returning experience from last season. I look to build off yesterday's best bet cash with Notre Dame covering +7.5 points in a game in beat Villanova in an outright upset.
Tipoff from Sanford Pentagon in Sioux Falls, S.D. is set for 7 p.m. ET tonight (FS1). Iowa State is a 13.5-point betting favorite.
Memphis vs. Iowa State picks & odds
See all of our experts' college basketball picks based on the latest college basketball odds.
| Pick | Odds | Bet size (units) |
|---|---|---|
| Iowa State -13.5 | -102 via DraftKings | 1 unit to profit 0.98 units |
| Memphis team total Under 71.5 | -120 via FanDuel | 1 unit to profit 0.83 units |
Picks submitted: Nov. 1 at 3:20 p.m. ET. Odds subject to change.
Total wagered: 2 units | Profit if all picks win: 1.81 units
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Memphis vs. Iowa State best bet
Iowa State -13.5 (-102 via DraftKings)
Iowa State returns three starters (Tamin Lipsey, Killyan Toure (out with injury), and Blake Buchanan) from a team that won 25 games in the regular season for the third time in program history. The Cyclones’ 29 wins overall were also tied for the second most in school history.
Despite losing sharpshooter Milan Momcilovic (transferred to Kentucky), the Cyclones still project to rank 24th in adjusted offensive efficiency (per KenPom). Memphis’ fast-paced attack that has ranked in the top 37 nationally in tempo should play right into Iowa State’s hands, as the Cyclones will look to space the floor in transition and knock down tons of 3-pointers.
Iowa State’s biggest advantage is a defense that projects to be second-best nationally in adjusted defensive efficiency. The unit is led by Lipsey, who is third in the history of the Big 12 in steals. It’s also a big reason the Cyclones have ranked in the top five in “Kill Shots” in each of the last three seasons, which is a measure of double-digit scoring runs.
Play to: -14 (-110)
Score prediction: Iowa State 84, Memphis 68
Memphis vs. Iowa State team prop
Follow all of our college basketball analysis and expert predictions this season.
Memphis team total Under 71.5 (-120 via FanDuel)
Iowa State finished last season 21st in the country in adjusted offensive efficiency, its highest ever ranking under head coach T.J. Otzelberger. But even with that dramatic offensive improvement, the Cyclones defense was still light years ahead, finishing in the top five and allowing just 65 points per game through six conference tournaments and NCAA Tournament games when the competition and stakes were the highest.
While this game is played at a neutral site and not Hilton Coliseum, it's worth noting that the Cyclones force more than 17 turnovers per game in home games over the last three seasons. That is the seventh-most in the country and leads Power Conference teams in that span.
Since Otzelberger took over as head coach, Iowa State has held 151 of 177 opponents below their season scoring average entering the game. And with this being the first game action from a Memphis team that is constructed differently from last year, there should be a lot of growing pains when facing the Cyclones right out the gate.
Play to: 69.5 (-110)
Live Memphis vs. Iowa State odds
See the latest odds movement and more on our Memphis vs. Iowa State matchup page.
Latest Memphis vs. Iowa State injuries
Iowa State:
- Christian Wiggins, G (Achilles) - Out
- Killyan Toure, G (Shoulder) - Out
How to watch Memphis vs. Iowa State
- Date: Monday, Nov. 2
- Tipoff: 7 p.m. ET
- Location: Sanford Pentagon (Sioux Falls, S.D.)
- TV/Streaming: FS1
Mike Spector X social