Colts vs. Jaguars Prediction: Week 8 Odds, Picks & Best Bet (Nov. 1)

Our Colts vs. Jaguars prediction for Week 8 includes our best bet, projected score, and the latest odds for Sunday's matchup.
Jacksonville Jaguars QB Trevor Lawrence reacts as we make our best Colts vs. Jaguars prediction.
Pictured: Jacksonville Jaguars QB Trevor Lawrence reacts as we make our best Colts vs. Jaguars prediction. Photo by Action Images via Reuters/Paul Childs
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An AFC South rivalry kicks off with one team engaging in a fire-sale, as the other looks to hold its divisional lead in my Colts vs. Jaguars prediction. 

The Jaguars are a 10.5-point betting favorite at home in EverBank Stadium from Jacksonville, Fla., leading up to Sunday's 1 p.m. ET kickoff (CBS). 


Colts vs. Jaguars picks & predictions

See all of our experts' NFL picks for Week 8 based on the latest NFL odds.

Pick Odds Bet size
Colts +10.5 -119 via bet365 1.19 units to profit 1.00 unit
Over 46.5  -105 via FanDuel 2.10 units to profit 2.00 units

Picks submitted: Oct. 30 at noon ET. Odds subject to change.

Total wagered: 3.29 units | Max profit: +3.00 units

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Colts vs. Jaguars prediction & best bet

Over 46.5 (-105 via FanDuel)

I like the Colts to give the Jaguars a fight in this game. However, the point total over appears to be the best bet in this matchup. 

Indianapolis is a bottom-10 scoring defense, allowing over 25 points per game this season. The Colts and Jaguars have both allowed 5.8 yards per play, tied for the fourth-worst mark in the league. 

While Indianapolis is trading away key pieces, it still has star RB Jonathan Taylor in the backfield. The Jaguars' offense is a top-10 scoring unit, posting 25.7 points per game this season, including 31+ points in three of six games. 

Coming out of a bye week, expect Jaguars head coach Liam Coen to have his group focused and ready to roll against a porous Colts defense that has only forced 1 turnover in its previous 3 contests. 

Go to FanDuel and bet Over 46.5 at -105 odds. 

📡 SBR Edge: AFC Road Kill

The Colts have gone over the total points line in 4 straight road games played against an AFC opponent. 

Jaguars' offense outlasts desperate Colts

The Jaguars, led by QB Trevor Lawrence, will put up numbers with a rest advantage and a top-10 offense that continues to trend upward. However, Jacksonville's defense is vulnerable, so expect Taylor and QB Daniel Jones to move the football downfield into scoring position enough to cover against a familiar divisional foe.

Ultimately, Lawrence and the Jaguars' offense will pull away late, scoring at least 27 points to beat the Colts for an eleventh straight time at EverBank Stadium. Taylor and the Colts do enough to break 20 points, losing by a touchdown and suffering a fourth straight loss. 

Play to: Over 46.5 (-120)

Score prediction: Jaguars 27, Colts 20


Live Colts vs. Jaguars odds

See the latest odds movement and more on our Colts vs. Jaguars matchup page.

Colts vs. Jaguars opening odds

  • Moneyline: Colts +180 | Jaguars -218
  • Spread: Colts +7.5 (-115) | Jaguars -7.5 (-105)
  • Over/Under: Over 49.5 (-105) | Under 49.5 (-115)

Colts vs. Jaguars weather

The forecast at EverBank Stadium in Jacksonville at opening kickoff is 75 F with 16 mph wind and a 34% probability of precipitation. Strong wind and the potential for rain could impact passing and kicking game. 


Latest Colts vs. Jaguars injuries


How to watch Colts vs. Jaguars: Week 8

  • Date: Sunday, Nov. 1
  • Kickoff: 1 p.m. ET
  • Location: EverBank Stadium (Jacksonville, Fla.)
  • TV/Streaming: CBS