March Madness First Round Schedule & Live Odds: 2025 NCAA Tournament Game Info

We're breaking down the March Madness first-round schedule with live odds and game info for all first-round games.
March Madness First Round Schedule & Opening Odds: NCAA Tournament Round 1 Betting Lines
Pictured: A member of the Creighton Bluejays shoots during NCAA Tournament First Round Practice at Rupp Arena. Photo by Aaron Doster-Imagn Images.

The most exciting three weeks in sports got underway yesterday afternoon, as March Madness has officially entered your living room. Auburn is the No. 1 seed entering the tournament, while Duke is the March Madness odds betting favorite. 

While the March Madness bracket will be front and center for the duration of the tournament, here's the March Madness first-round schedule and opening odds, complete with game times and TV schedule. 

Our C Jackson Cowart asked ChatGPT to fill out a March Madness bracket with a predicted score for every game.

🗓️ March Madness first round schedule

Here is the full March Madness first-round schedule with the NCAA Tournament beginning in full on Thursday. Listed odds are from BetMGM.

Day Matchup Time How to watch
Friday  No. 9 Baylor (-1.5) vs. No. 8 Mississippi State 12:15 p.m. ET  CBS
Friday No. 15 Robert Morris vs. No 2 Alabama (-3.5) 12:40 p.m.  truTV
Friday No. 14 Lipscomb vs. No. 3 Iowa State (-13.5) 1:30 p.m. ET  TNT
Friday No. 12 Colorado State (-3.5) vs. No. 5 Memphis 2 p.m. ET  TBS
Friday Mount St. Mary's vs. No. 1 Duke  2:50 p.m. ET CBS
Friday No. 10 Vanderbilt vs. No. 7 Saint Mary's (-4.5) 3:15 p.m. ET truTV
Friday No. 11 North Carolina vs. No. 6 Ole Miss 4:05 p.m. ET TNT
Friday No. 13 Grand Canyon vs. No. 4 Maryland 4:35 p.m. ET TBS
Friday No. 16 Norfolk State vs. No. 1 Florida (-27.5) 6:50 p.m. ET TNT 
Friday No. 14 Troy vs. No. 3 Kentucky (-10.5) 7:10 p.m. ET CBS
Friday  No. 10 New Mexico vs. No. 7 Marquette (-3.5) 7:25 p.m. ET TBS
Friday No. 13 Akron vs. No. 4 Arizona (-14.5) 7:35 p.m. ET truTV
Friday No. 9 Oklahoma vs. No. 8 UConn (-4.5) 9:25 p.m. ET TNT
Friday No. 11 Xavier vs. No. 6 Illinois 9:45 p.m. ET CBS
Friday No. 15 Bryant vs. No. 2 Michigan State (-19.5) 10 p.m. ET TBS
Friday  No. 12 Liberty vs. No. 5 Oregon  10:10 p.m. ET truTV

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👉 See all of the college basketball odds from our best March Madness betting sites.

🏀 March Madness odds & predictions for Friday

Here are Friday's March Madness odds:

No. 16 Norfolk State vs. No. 1 Florida odds, 6:50 p.m. ET

  • When: Friday, March 21 | 6:50 p.m. ET
  • Where: Lenovo Center (Raleigh, N.C.)
  • How to watch: TNT

No. 14 Troy vs. No. 3 Kentucky odds, 7:10 p.m. ET

  • When: Friday, March 21 | 7:10 p.m. ET
  • Where: Fiserv Forum (Milwaukee)
  • How to watch: CBS

No. 10 New Mexico vs. No. 7 Marquette odds, 7:25 p.m. ET

  • When: Friday, March 21 | 7:25 p.m. ET
  • Where: Rocket Arena (Cleveland)
  • How to watch: TBS

No. 13 Akron vs. No. 4 Arizona odds, 7:35 p.m. ET

  • When: Friday, March 21 | 7:35 p.m. ET
  • Where: Climate Pledge Arena (Seattle)
  • How to watch: truTV

No. 9 Oklahoma vs. No. 8 UConn odds, 9:25 p.m. ET

  • When: Friday, March 21 | 9:25 p.m. ET
  • Where: Lenovo Center (Raleigh, N.C.)
  • How to watch: TNT

No. 11 Xavier vs. No. 6 Illinois odds, 9:45 p.m. ET

  • When: Friday, March 21 | 9:45 p.m. ET
  • Where: Fiserv Forum (Milwaukee)
  • How to watch: CBS

No. 15 Bryant vs. No. 2 Michigan State odds, 10 p.m. ET

  • When: Friday, March 21 | 10 p.m. ET
  • Where: Rocket Arena (Cleveland)
  • How to watch: TBS

No. 12 Liberty vs. No. 5 Oregon odds, 10:10 p.m. ET

  • When: Friday, March 21 | 10:10 p.m. ET
  • Where: Climate Pledge Arena (Seattle)
  • How to watch: truTV

⏰ When is March Madness Round 1?

The first round of the 2025 NCAA Tournament takes place over Thursday and Friday with 16 games each day.

The First Four games will be played Tuesday and Wednesday, with two games each day. The second round of March Madness will begin Saturday with eight games played on each of Saturday and Sunday.

💰 March Madness betting odds pages

👑 Best March Madness betting sites

Ready to place your March Madness bets? Check out the best March Madness betting promos from the best March Madness betting sites, as determined by our expert team at Sportsbook Review.

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