March Madness Predictions Today: Expert Picks & Scores for Every NCAA Tournament Game

After the first round of the NCAA Tournament saw most of the favorites advance and cover the spread, our March Madness predictions today expect a little more upheaval with the first game of the second round tipping off at 12:10 p.m. ET.

We've gathered all our experts' picks against the spread and score predictions for all eight games today to open the second round of the 2025 NCAA Tournament.

👉 Can't get enough March Madness action? Check out the rest of our March Madness second-round expert picks as part of our March Madness predictions.

💰 March Madness predictions, NCAA Tournament odds & expert picks today

📅  Saturday's March Madness odds & schedule

🏀 No. 1 Auburn vs. No. 9 Creighton, 7:10 p.m. ET (TBS/truTV), South Region

✅ ATS prediction: Auburn to cover the spread -9.5 ⭐⭐⭐⭐
🎯 Score prediction: Auburn 88, Creighton 73

Here's why Phil Wood is picking Auburn to cover the spread (-9.5):

"The lackluster start for the No. 1 overall seed has made the betting public nervous, as 72% of bettors are backing the Bluejays against the spread. However, the spread has been growing from 8.5 to 9.5 at most of our best sportsbooks, which means oddsmakers aren’t trying to offset the public action."

👉 For more analysis, check out our Auburn vs. Creighton prediction.

📊 Auburn vs. Creighton odds

🏀 No. 3 Wisconsin vs. No. 6 BYU, 7:45 p.m. ET (CBS), East Region

✅ ATS prediction: BYU to cover the spread +1.5 ⭐⭐⭐
🎯 Score prediction: BYU 80, Wisconsin 78

Here's why Mike Spector is picking BYU to cover the spread (+1.5):

"It is fair to wonder if BYU received an underrated advantage playing at altitude in Denver against a VCU unfamiliar with the environment on just four days' rest after winning its conference championship. Nevertheless, the Cougars lit up one of the best defenses in the country to the tune of 1.23 points per possession."

👉 For more analysis, check out our Wisconsin vs. BYU prediction.

📊 Wisconsin vs. BYU odds

🏀 No. 1 Houston vs. No. 8 Gonzaga, 8:40 p.m. ET (TNT), Midwest Region

✅ ATS prediction: Gonzaga to cover the spread +5.5 ⭐⭐⭐⭐
🎯 Score prediction: Gonzaga 74, Houston 71

Here's why Brenden Schaeffer is picking Gonzaga to cover the spread (+5.5):

"To get here, Gonzaga treated Georgia like it was a scrimmage opponent in the opening round, opening up a 27-3 lead out of the gates and finishing with a 21-point win. Houston will present more of a stylistic challenge for the Bulldogs, as the Cougars’ dictating tempo could frustrate a Gonzaga team that wants to play fast."

👉 For more analysis, check out our Houston vs. Gonzaga prediction.

📊 Houston vs. Gonzaga odds

🏀 No. 2 Tennessee vs. No. 7 UCLA, 9:40 p.m. ET (TBS/truTV), Midwest Region

✅ ATS prediction: Tennessee to cover the spread -4.5 ⭐⭐⭐⭐
🎯 Score prediction: Tennessee 68, UCLA 62

Here's why Brenden Schaeffer is picking Tennessee to cover the spread (-4.5):

"Although UCLA’s 25-point win over Utah State in the first round may convince some bettors that the Bruins are a value getting 4.5 points on Saturday night, I’m not taking too much away from that result. Utah State was the worst at-large team in the NCAA Tournament field according to the KenPom rankings. Tennessee will present a vastly different challenge."

👉 For more analysis, check out our Tennessee vs. UCLA prediction.

📊 Tennessee vs. UCLA odds

🏀 Best March Madness odds, predictions & expert picks today

Here are our best March Madness picks for Saturday's second-round action:

• March Madness odds & schedule today
• March Madness survivor pool picks today
• March Madness predictions today
• Best March Madness player props today
• March Madness upset picks today

💰 March Madness betting odds pages

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