Final Four Odds After Bracket Reveal: Duke Fronts Favorites to Reach San Antonio

Duke, Florida, Houston, and Auburn are the betting favorites by the updated Final Four odds after the March Madness bracket was revealed on Selection Sunday.

Esten McLaren

Last updated: March 16, 2025 11:55 PM EDT • 5 min read

Final Four Odds After Bracket Reveal: Who'll Advance to San Antonio? — Pictured: Florida players celebrate their win over Tennessee after the SEC tournament championship. Photo by Denny Simmons / The Tennessean via Imagn Images.

The bracket's been revealed for the 2025 NCAA Tournament with Duke, Auburn, Florida, and Houston as the No. 1 seeds. Those schools are also the betting favorites by the Final Four odds as they'll try to advance to San Antonio for the March Madness semifinals on Saturday, April 5.

The NCAA Tournament begins Tuesday with the First Four games with the first round of March Madness beginning Thursday. We're looking ahead while aiming to help your March Madness bracket predictions.

There's long been similarities between the Final Four odds and the March Madness odds, and Duke and Auburn have long paced the field in both futures betting markets.

4️⃣ Final Four odds 2025

Our updated Final Four odds are from our best sports betting sites and update in real time throughout March Madness. Visit Sportsbook Review during the NCAA Tournament to get the best college basketball prop bets today.

Odds to win East region

Duke (1) and Alabama (2) have the shortest odds of the 16 teams in the East region. They could potentially meet in the Elite Eight.

Odds to win Midwest region

Houston (1) leads Tennessee (2) by the odds to make the Final Four out of the Midwest region:

Before locking in any of your picks to make the Final Four, be sure to check out the March Madness betting promos and our March Madness bracket challenges. Futures bets will be paid out following the national championship game on Monday, April 7.

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Odds to win South region

Auburn (1) is the favorite to win the South region over Michigan State (2). Auburn's the third-biggest favorite in the regional betting markets, behind Duke and Florida, who're both offered with minus-money odds.

Odds to win West region

Florida (1) is the second-biggest favorite behind Duke to reach the Final Four. Texas Tech, the region's No. 3 seed, actually has shorter odds than St. John's (2) to make the Final Four. Those two teams could meet in the Sweet 16.

🏆 Final Four odds 2025: Teams to watch

😈 Duke

Duke won the ACC tournament mostly without the services of star freshman Cooper Flagg. With Flagg expected to be available for the NCAA Tournament, the Blue Devils are thus being penciled in to win the East region and make the Final Four in San Antonio.

Duke's odds to make the Final Four float around -110, representing an implied win probability of 52.38% at FanDuel.

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🐯 Auburn

Auburn has +110 odds at FanDuel of winning the South region. The biggest competition is expected to come from Michigan State (+480), the region's second seed.

🐊 Florida

Florida joins Duke as the only other school at minus-money to win its region. The Gators won the SEC tournament over Tennessee on Sunday and will face Norfolk State in the first round of the NCAA Tournament.

🛑 Houston

At +165 on FanDuel, Houston has the longest odds of any of the No. 1 seeds to make the Final Four. Tennessee (+340) is expected to pose the biggest challenge in that region.

🧠 March Madness bracket tips

Here are our college basketball betting experts' best March Madness bracket tips:

🔢 Final Four betting history

Here is a look at the Final Four odds history. UConn had +2000 pre-season odds last season. The year prior the Huskies had +8000 odds.

Year	March Madness champion	Preseason Final Four odds
2023-24	UConn	+2000
2022-23	UConn	+8000
2021-22	Kansas	+1400
2020-21	Baylor	+800
2018-19	Virginia	+1350
2017-18	Villanova	+2700
2016-17	North Carolina	+1900
2015-16	Villanova	+2500
2014-15	Duke	+900
2013-14	Connecticut	+6500
2012-13	Louisville	+700

❓March Madness FAQs

Who is the March Madness 2025 favorite?

The Duke Blue Devils are the favorites to win the 2025 NCAA Tournament with +350 odds. Those odds imply a win probability of 22.22%.

When is the Final Four?

The Final Four will be played Saturday, April 5 ahead of the national championship on Monday, April 7.

Where will the Final Four be played?

The Final Four of the 2025 NCAA Tournament will be played at the Alamodome in San Antonio.

💰 March Madness betting odds pages

March Madness odds	March Madness MVP odds
Women's March Madness odds	March Madness MVP predictions
Final Four odds	March Madness prop bets

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Written By:
Esten McLaren

Esten is the Senior Publishing Editor for SportsbookReview.com. He has been in the sports betting industry since the legalization of mobile sports betting in New Jersey, and with SportsbookReview prior to the launch of sports betting in Ontario. Esten's previous stops include the USA TODAY network, including GolfWeek. He previously worked in the fantasy sports industry, with FNTSY Sports Network, theScore, and USA TODAY. Esten graduated from the College of Sports Media with a diploma in Radio and Television Sports Broadcasting after acquiring a degree in Biological Sciences from the University of Guelph. He has appeared on FNTSY Sports Network, VSiN, and VSiN's Long Shots podcast, where he correctly called Will Zalatoris as the winner of the 2022 FedEx St. Jude Championship. Esten is a big proponent of the entertainment side of sports betting and loves to dip his toes into the novelty and alt-markets while chasing long shots with reduced wagers on golf outrights and futures markets. He's also been known to sprinkle some lunch money on touchdown-scorer parlays with two notable hits still funding his bankroll. Esten looks at sports betting much like golf and advises beginner bettors to compete against themselves rather than being concerned with what others may or may not be doing based on social media claims.