Padres vs. Dodgers Prediction & Picks: MLB Odds for Today, Sept. 22
NL West rivals go at it tonight as the San Diego Padres visit the Los Angeles Dodgers for the series opener of a three-game set. While both teams are red-hot, my Padres vs. Dodgers predictions back LA because of Yoshinobu Yamamoto's dominance.
I'll also reveal two additional MLB picks, including a player prop, ahead of tonight's first pitch from Dodger Stadium at 10:10 p.m. ET (MLB.TV). The Dodgers are a -120 home moneyline favorite.
โพ Padres vs. Dodgers picks & odds today
See all of our expertsโ MLB picks based on the latest MLB odds.
| Pick | Best Odds | Units |
|---|---|---|
| Dodgers ML | -120 via DraftKings | 1.5 units to win 1.25 units |
| Mookie Betts Over 1.5 total bases | +131 at DraftKings | 1.00 units to win 1.31 units |
| Mookie Betts to hit a HR | +532 at DraftKings | 0.25 units to win 1.33 units |
Total wagered: 2.75 units | Max profit: 3.89 units
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๐ Who will win Padres vs. Dodgers?
I can't help but back Yamamoto. He is dominating everyone right now, but the Padres' offense, just like LA's, is swinging the bat with authority. I'm predicting a high-scoring contest here, with the Dodgers coming out on top. Most of the runs could come late.
Score prediction: Padres 4, Dodgers 7
๐ฐ Padres vs. Dodgers prediction & best bet
Dodgers ML (-120)
Yamamoto has been the Dodgers' healthiest and best starter in 2026. The Japanese phenom owns a 2.40 xERA across his last four starts, holding opponents to a 36.7% hard-hit rate and a .140 average. Yamamoto has carved up the Padres this season, posting a 1.35 ERA over three outings. San Diego is raking, but this matchup will prove to be a difficult one.
Michael King, on the other hand, has a 4.02 FIP in his previous two appearances, and the Dodgers have a 160 wRC+ in the last week. He's pitched respectably against LA this season, but King hasn't been untouchable, and he won't be able to outduel Yamamoto.
📡 SBR Edge: Dodgers destroying baseballs
The Dodgers are hitting .311 as a lineup over their last six games. For comparison, the defending champions are batting .257 as a team overall.
๐ฅ Best Padres vs. Dodgers player prop bet
Mookie Betts Over 1.5 total bases (+131)
Mookie Betts is tearing the cover off the baseball at the moment. The veteran is hitting .500 over the last week with an impressive .450 ISO.
Betts is 6-for-21 lifetime against King, and he has 10 hits in his previous three contests. Yes, you read that correctly. Also, five of those hits have been for extra bases.
With the Padres bullpen also giving up hard contact, Betts is worth a serious look for another big performance at the dish.
๐ฃPadres vs. Dodgers home run prediction
Mookie Betts (+532)
I'm sticking with Betts for my home run pick. He has two bombs in his last three games, and of his six hits lifetime vs. King, three left the yard. Betts has a 47.4% hard-hit rate recently, and he's consistently getting lift.
Betts has a 52.6% FB rate over the last seven days, and with a strong history against King, don't be surprised if he makes his presence felt in the first game of this highly anticipated series.
๐ Live Padres vs. Dodgers odds
๐ Padres vs. Dodgers betting trends
| Padres | Statistic | Dodgers |
|---|---|---|
| 87-69 | W-L record | 96-60 |
| 88-68 | Run line record | 66-90 |
| 74-78-4 | O/U record | 72-80-4 |
| 9-1 | Last 10 games | 7-3 |
| 3.94 | Team ERA | 3.62 |
| .244 | Team batting avg. | .257 |
| .719 | OPS | .765 |
๐ Padres vs. Dodgers injuries
๐บ How to watch Padres vs. Dodgers
- Date: Tuesday, Sept. 22
- First pitch: 10:10 p.m. ET
- Ballpark: Dodger Stadium (Los Angeles)
- TV: Local
- Streaming: MLB.TV
- Padres starter: Michael King (12-9, 3.03 ERA)
- Dodgers starter: Yoshinobu Yamamoto (14-8, 2.51 ERA)
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