Dodgers vs. Giants Prediction & Picks: MLB Odds for Friday, Sept. 25

My Dodgers vs. Giants prediction breaks down the best bets, player props, and home run pick I’m betting today.
Dodgers shortstop Mookie Betts (50) hits a double as we break down our Dodgers vs. Giants prediction.
Pictured: Dodgers shortstop Mookie Betts (50) hits a double as we break down our Dodgers vs. Giants prediction. Photo by William Liang / Imagn Images.
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Giants starter Yunior Marte will get his second crack at the Dodgers tonight, after their stacked lineup dominated him just last week. Meanwhile, Tarik Skubal will look to pick up his second win in six days against the Giants. My Dodgers vs. Giants prediction focuses on Marte's struggles against Los Angeles.

My MLB picks also focus on Mookie Betts and Will Smith in a game the Dodgers will dominate. The Dodgers are a -337 betting favorite, with first pitch from Oracle Park in San Francisco set for 10:15 p.m. ET (MLB.TV).


⚾ Dodgers vs. Giants picks & odds today

See all of our experts’ MLB picks based on the latest MLB odds.

Pick Best Odds Units
Dodgers Over 4.5 runs -120 via bet365 2.5 units to win 2.08 units
Mookie Betts Over 1.5 total bases +110 via bet365 2 units to win 2.2 units
Will Smith to hit a home run +600 via BetMGM 0.25 units to win 1.5 units

Total wagered: 4.75 units | Max profit: +5.78 units

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πŸ† Who will win Dodgers vs. Giants?

I'm taking the Dodgers to win this one 9-3. Marte was no match for the Dodgers the last time he faced them, and I expect him to struggle again against the league's fourth-highest-scoring team.

Score prediction: Dodgers 9, Giants 3


πŸ’° Dodgers vs. Giants prediction & best bet

Dodgers Over 4.5 runs (-120)

The Dodgers just faced Marte last Saturday, and they absolutely crushed him. In 4.2 innings, Marte allowed eight hits and six earned runs, as the Dodgers went on to win 10-4. The Dodgers scored in all five innings that Marte pitched.

That was the first time that the Giants' young right-hander had ever faced the Dodgers, and he enters this game allowing Los Angeles to hit .400 off him with an OPS of 1.155. Four of the Dodgers' eight hits against him have been for extra bases. 

📡 SBR Edge: The Giants' bullpen can't pick up the slack

Marte should be chased early in this game, and when he is, the Dodgers should still score plenty against a bullpen that ranks 22nd in ERA.


πŸ”₯ Best Dodgers vs. Giants player prop bet

Mookie Betts Over 1.5 total bases (+110)

Betts was Marte's biggest challenge last week. By the time Marte was pulled from the game, Betts was 3-for-3 with two doubles. Now, Betts enters this game hot after a three-hit performance against the Padres last night. He has at least three hits in four of his last seven games, and he's topped 1.5 total bases in five contests during that span. 

I believe that there's even some value in taking Betts Over 2.5 total bases. After all, in his four starts, Marte has allowed 18 total hits. Seven of them have been for extra bases.

💵 More MLB props today

Looking for more? Dive into Mike Spector's best NRFI bets today.


πŸ’£ Dodgers vs. Giants home run prediction

Will Smith to hit a home run (+600)

Smith has only hit 10 home runs this season, but his power has been on display over the last week, as he's hit three home runs in his last five games. One of those homers came off Marte last Saturday. 

Out of the 865 pitchers who have thrown a pitch this season, Marte ranks 116th in barrels per plate appearance, allowing a barreled ball to 8.4% of the batters he's faced. This makes Smith a very bad matchup for him, as he has hit a barreled ball in 8.9% of his plate appearances, which ranks 45th of 657 this season.


πŸ“Š Live Dodgers vs. Giants odds

Unsurprisingly, the Dodgers are seeing an overwhelming amount of action ahead of this game. I'd back them to win by 1.5 in a parlay, but with the price where it is, I'd look to get them at -2.5 in a straight play. As for the total, the Over is seeing a lot of support. The number opened at 7, but it has increased to 7.5, and with 81% of bets backing the Over, I could see this jumping to 8.


πŸ“ˆ Dodgers vs. Giants betting trends

Dodgers Statistic Giants
97-62 W-L record 65-94
67-92 Run line record 82-77
72-83-4 O/U record 76-71-12
7-3 Last 10 games 3-7
3.59 Team ERA 4.36
.257 Team batting avg. .246
.764 OPS .711

πŸš‘ Dodgers vs. Giants injuries


πŸ“Ί How to watch Dodgers vs. Giants

  • Date: Friday, Sept. 25
  • First pitch: 10:15 p.m. ET
  • Ballpark: Oracle Park (San Francisco)
  • Streaming: MLB.TV
  • Dodgers starter: Tarik Skubal (11-7, 2.85 ERA)
  • Giants starter: Yunior Marte (0-1, 4.66 ERA)