MLB Best Home Run Predictions Today: Best HR Props, Picks, Parlay & Odds for Friday, Sept. 25
Multiple doubleheaders today mean we have a loaded 17-game MLB slate to bet on for my home run predictions today. It was another losing day Thursday, as Matt Olson and Kyle Tucker came up just short with fly balls to the warning track.
The late games have a lot of home run value baked in due to their forecast, which is why I'm starting my MLB home run picks with Isaac Paredes. The Astros third baseman is playing in a hitter-friendly ballpark tonight at Sutter Health Park in West Sacramento, Calif., with winds blowing out at 10.9 mph.
⚾ Home run predictions today: MLB HR picks & odds Sept. 25
See all of our experts’ MLB picks based on the latest MLB odds.
| Home run pick | Units | Notes |
|---|---|---|
| Isaac Paredes (+401 via DraftKings) | 0.25 units to win 1 unit | Paredes has hit 3 home runs in his last 5 outings. |
| Randy Arozarena (+508 via DraftKings) | 0.25 units to win 1.27 units | Winds blowing out at 12.9 mph at T-Mobile Park tonight. |
| Shohei Ohtani (+310 via BetMGM) | 0.33 units to win 1.02 units | Winds blowing out at 16.2 mph at Oracle Park tonight. |
Total wagered: 0.83 units | Max profit: +3.29 units
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💣 Best home run predictions & odds today
Home run pick: Isaac Paredes (+401)
While Paredes has weather and a hitter-friendly ballpark on his side tonight, he's also been hot at the plate for the Astros. In his last 5 appearances, Paredes has hit 3 home runs. This includes a homer at Sutter Health Park on Thursday night.
Jacob Lopez is starting for the Athletics. The southpaw has surrendered 7 home runs in his last 4 starts. He's an ideal matchup for a right-handed hitter like Paredes.
Go to DraftKings to get the best line on Paredes' home run prop at +401 odds.
- Time: 9:40 p.m. ET
- Where to watch: MLB.TV
📡 SBR Edge: September to Remember
Paredes has hit seven home runs in September, all recorded in separate contests.
🔥 More home run predictions today
Home run pick: Randy Arozarena (+508)
T-Mobile Park is infamous for its difficult hitting conditions as a pitcher-friendly ballpark. However, tonight's forecast calls for winds blowing out at 12.9 mph, boosting Arozarena's appeal in the home run prop betting market.
The right-handed slugger ranks in the 81st percentile for avg exit velo (90.8) and faces southpaw, Reid Detmers, who has allowed a home run in consecutive starts for the Angels.
Detmers is giving up an 89.8 mph avg exit velo, which feeds right into Arozarena's strength. The Mariners' LF is also getting a major boost from tonight's wind gusts, while recording 5 home runs in September.
Stay on DraftKings and bet on Arozarena's home run at +508 odds.
- Time: 10:10 p.m. ET
- Where to watch: MLB.TV
💵 More MLB props today
Looking for more? Dive into Mike Spector's best NRFI bets today.
Home run pick: Shohei Ohtani (+310)
It's been a long time since Ohtani hit a home run, carrying a 15-game slump into tonight's matchup against the Giants at Oracle Park. However, the Dodgers' star hitter has 16.2 mph wind gusts blowing out to help him find the bleachers at a pitcher-friendly ballpark.
Ohtani faces Yunior Marté, who has allowed 3 home runs in his previous 3 appearances. It's an ideal matchup for Ohtani, who has hit 18 of his 30 home runs against right-handed pitching this season.
Ohtani's power metrics are still at the top of the charts. He's ranked in the 99th percentile for barrel percentage (16.6) and xSLG (.560) in 2026.
BetMGM offers the best line on Ohtani's home run prop at +310 odds.
- Time: 10:15 p.m. ET
- Where to watch: MLB.TV
⚾️ More MLB player props today
Our Phil Wood features Mookie Betts and Will Smith in his Dodgers vs. Giants prediction.
🚀 Best home run parlay picks today
💵 Best MLB home run parlay today
- Isaac Paredes (+401)
- Randy Arozarena (+508)
- Shohei Ohtani (+265)
Best odds: +11018 via DraftKings (0.1 units to win 11.01 units)
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Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
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