Colorado vs. Baylor Prediction: Week 4 Odds, Picks & Best Bet
Last Updated: September 25, 2026 2:00 PM EDT • 2 minute read X Social Google News Link
My Colorado vs. Baylor prediction features a Big 12 matchup with two teams trending in opposite directions. Colorado head coach Deion Sanders needs to figure out a way to improve his team quickly, while Dave Aranda's Bears have outscored their last 2 opponents 80-22.
Baylor enters as a -9.5-point betting favorite at home from McLane Stadium in Waco, Texas, with opening kickoff scheduled for 12:00 p.m. ET (ESPN2).
🏈 Colorado vs. Baylor picks & predictions
See all of our experts' college football picks for Week 4 based on the latest college football odds.
| Pick | Bet size |
|---|---|
| Baylor -9.5 (-112 via BetMGM) | 1.12 units to win 1.0 units |
| Under 55.5 (-110 via DraftKings) | 2.20 units to win 2.0 units |
Total wagered: 3.32 units | Max profit: 3.0 units
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💰 Colorado vs. Baylor prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Under 55.5 (-110 via DraftKings)
Colorado's offense isn't scaring any opponent right now. The Buffaloes have a ton of turnover from last season and have mustered just 21 points against 2 FBS opponents.
Baylor's defense is an underrated unit. The Bears have allowed only 1 passing touchdown through 3 games, while forcing 6 turnovers.
The point total has steamed up from 53.5 to 55.5, creating even more value on the under since we're through key numbers of 52 and 55. Colorado's offense was just held to 7 points on the road against Northwestern, while Baylor hasn't averaged more than 3.8 YPC against either of its FBS opponents.
Under 55.5 is a 2.20-unit play as my best bet for Colorado vs. Baylor. Go to DraftKings to bet Under 55.5 at -110 odds.
📡 SBR Edge: Unranked Unders
Five of Baylor's previous six games played against non-ranked opponents have gone Under the total points line.
Colorado's offensive woes continue in Waco
Colorado's rushing attack has only 3 touchdowns from QB Julian Lewis and RB Micah Welch. Baylor's also forced 2 fumbles and 4 interceptions, while limiting all 3 opponents to 1 total passing touchdown.
Welch and the Buffaloes' offense have not surpassed 168 passing yards against Georgia Tech or Northwestern. Both of those contests were on the road. Colorado's offense just committed 4 turnovers against the Wildcats in Week 3, so expect Baylor to limit Welch and the Buffaloes at home on Saturday.
Score prediction: Baylor 38, Colorado 17
📊 Colorado vs. Baylor odds
See the latest college football odds for every Week 4 matchup.
Colorado vs. Baylor opening odds
- Moneyline: Colorado +210 | Baylor -260
- Spread: Colorado +8.5 (+100) | Baylor -8.5 (-120)
- Over/Under: Over 53.5 (-115) | Under 55.5 (-105)
📺 How to watch Colorado vs. Baylor: Week 4
- Date: Saturday, Sept. 26
- Kickoff: 12:00 p.m. ET
- Location: McLane Stadium (Waco, Texas)
- TV: ESPN2
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