South Carolina vs. Alabama Prediction: Week 4 Odds, Picks & Best Bet

The SEC will be on full display during a prime-time tilt in Week 4 with my South Carolina vs. Alabama prediction. No. 8 Alabama has been a juggernaut on offense, averaging 47.7 points per game this season, while South Carolina just blew a 16-0 lead at home to No. 24 Mississippi State. 

Alabama is a -12.5-point betting favorite entering this home game at Bryant-Denny Stadium in Tuscaloosa, Ala., leading up to Saturday night's opening kickoff at 7:00 p.m. ET (ESPN). 

🏈 South Carolina vs. Alabama picks & predictions

See all of our experts' college football picks for Week 4 based on the latest college football odds.

Total wagered: 3.26 units | Max profit: 3.00 units

💰 South Carolina vs. Alabama prediction & best bet

Check out all of our college football predictions for more analysis across this week's slate.

Alabama -12.5 (-108 via BetMGM)

The Crimson Tide's offense runs through QB Keelon Russell. He's a dual-threat signal-caller, logging 24-133-2 as a ball carrier, while recording a 68 percent completion rate with over 750 passing yards. 

Alabama head coach Kalen DeBoer has seemingly unlocked the ceiling of his offense. The Crimson Tide have scored 11 rushing touchdowns and are averaging 5.0 YPC. Alabama has also battled adversity, despite its final scoreboard results, erasing deficits against Kentucky and Florida State in consecutive weeks. 

LaNorris Sellers is an experienced quarterback for the Gamecocks. He's posting 7.5 YPC but only has a 62 percent completion rate, with 5 touchdowns and 3 interceptions.

South Carolina head coach, Shane Beamer, has never led the program to a 10-win season during his 6-year tenure. Following the latest loss to Mississippi State, there's a ton of pressure on the Gamecocks to post a signature win.

Alabama is simply too much to handle for South Carolina. It's a hostile environment under the lights, the first road game for the Gamecocks in 2026, and the Crimson Tide will chew up a South Carolina defense that just gave up 4.0 YPC and 5 passing touchdowns to Kamario Taylor's Bulldogs in Week 3.

We're laying a bit of a premium on Alabama -12.5. However, we're still through a key number below 13.5 and 14.5, so let's go to BetMGM and bet on Alabama -12.5 against South Carolina. 

DeBoer's High-Octane Offense Shreds the Gamecocks

Alabama has been a wagon all season, scoring 45+ points in every game. After falling 21-6 to Florida State in Tuscaloosa last week, the Crimson Tide rallied with 44 points in the final 32 minutes of their matchup. 

The Crimson Tide have held opponents to 1.8 YPC and have forced 4 interceptions in consecutive matchups. The Gamecocks just gave up over 250 passing yards and 5 touchdowns through the air, so expect Russell and Alabama to throttle South Carolina. 

Score prediction: Alabama 48, South Carolina 23

📊 South Carolina vs. Alabama odds

See the latest college football odds for every Week 4 matchup.

South Carolina vs. Alabama opening odds

• Moneyline: South Carolina +350 | Alabama -460
• Spread: South Carolina +11.5 (-115) | Alabama -11.5 (-105)
• Over/Under: Over 46.5 (-120) | Under 46.5 (+100)

📺 How to watch South Carolina vs. Alabama: Week 4

• Date: Saturday, Sept. 26
• Kickoff: 7:00 p.m. ET
• Location: Bryant-Denny Stadium (Tuscaloosa, Ala.)
• TV: ESPN