Tulane vs. Charlotte Prediction, Picks & Odds for Tonight

Tulane is unbeaten in American Athletic Conference play as it rolls into Charlotte, and we like the visitors to cover the notable spread in tonight's Week 10 action.
Oklahoma Sooners defensive lineman Trace Ford pressures Tulane Green Wave quarterback Darian Mensah as we offer our Tulane vs. Charlotte prediction.
Oklahoma Sooners defensive lineman Trace Ford pressures Tulane Green Wave quarterback Darian Mensah. Photo by Bryan Terry/The Oklahoman/USA Today via Imagn Images

Tulane is on a roll and looks to make it six straight wins it faces Charlotte at Jerry Richardson Stadium for tonight's Week 10 tilt.

Tulane is unbeaten in American Athletic Conference play and enters the game as favorites across our best college betting sites. The line hasn't moved much in the lead-up to the game, with Tulane favored between 14.5 and 15.5 points. 

Our Tulane vs. Charlotte prediction backs the Green Wave to cover the spread, expecting them to dole out a heavy dose of Makhi Hughes. 

The below picks are part of our college football Week 10 predictions

Best Tulane vs. Charlotte picks

College football picks based on the odds from our best college football betting sites. Odds subject to change.

Tulane vs. Charlotte against the spread prediction: Week 10

Tulane to cover the spread: -15.5 (-110) ⭐⭐⭐⭐

Tulane vs. Charlotte opening odds:

  • Tulane: -16.5 (-110)
  • Charlotte: +16.5 (-110)

Tulane is 6-2 against the spread and boasts the fifth-best average ATS margin in the nation (+10.7). The Green Wave haven't faltered under the pressure of road environments, going 3-1 ATS.

49ers are flimsy against quality teams 

Charlotte’s 4-4 ATS record hides the extent of its struggles against quality opponents. The 49ers have three wins, beating FCS program Gardner-Webb and adding conference wins over Rice and East Carolina, which rank 115th and 96th in FPI’s overall adjusted efficiency, respectively.

The Niners are 0-5 against teams ranked 65th or better in overall adjusted efficiency. Four of those five losses came by 18 or more points, with an average margin of defeat of 23.6 PPG. Tulane ranks 25th nationally in overall adjusted efficiency.

Play this spread at BetMGM or FanDuel, which list Tulane at -15.5 with -110 odds. DraftKings has the same spread with -112 odds. Avoid the line at Caesars and bet365 (Tulane -16) for this spread bet. A winning $10 bet yields a $9.09 profit. 

Best odds: -110 via BetMGM | Implied probability: 52.38%

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Tulane vs. Charlotte best bet

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Makhi Hughes Over 129.5 rushing yards (-115) ⭐⭐⭐⭐⭐

This AAC clash is a mismatch on the ground for a Charlotte defense that has allowed 5.2 yards per rushing attempt (115th in FBS) and 203.6 rushing yards per game (118th in FBS).

The Green Wave has the 10th-ranked rushing attack in FBS, averaging 213.3 rushing yards per game. It is led by a sophomore running back who has rumbled for three straight triple-digit rushing efforts.

Green Wave should run the rock—and roll

Makhi Hughes has averaged 136.2 rushing yards per game over the previous five games, clearing this rushing total in three of the five.

After logging 27 and 30 rushing attempts over his last two games, there’s nothing scary about Hughes’ workload—unless you’re facing him on Halloween night as one of the nation’s worst run-stopping units.

The best edge on Hughes’ rushing prop comes from Caesars, listed at 129.5 yards with -115 odds on Over. Avoid the inflated 133.5-yard rushing total at bet365.

Our Shane Jackson is taking a different approach to this game while fading one of Tulane's top receivers in his college football Week 10 player prop picks.

Best odds: -115 via Caesars | Implied probability: 53.49%

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Tulane vs. Charlotte odds

See all of this week's college football odds and NCAAF scores.

Tulane vs. Charlotte game info

  • When: Thursday, Oct. 31
  • Kickoff: 7:30 p.m. ET
  • Where: Jerry Richardson Stadium (Charlotte, N.C.)
  • How to watch: ESPN
  • Weather: 68 degrees, 20% chance of precipitation, wind 6 mph S
  • Favorite: Tulane -15.5 (-110 via BetMGM)

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