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Jaren Hall of the Brigham Young Cougars throws a pass against the Wyoming Cowboys during the first half of their game September 24, 2022 at LaVell Edwards Stadium in Provo, Utah.
Jaren Hall of the Brigham Young Cougars throws a pass against the Wyoming Cowboys during the first half of their game September 24, 2022 at LaVell Edwards Stadium in Provo, Utah. Photo by Chris Gardner/Getty Images via AFP.

Our college football experts offer their top picks and predictions for Week 5.

Conference schedules ramp up in Week 5 of the 2022 college football season. Saturday's slate features six ranked-on-ranked matchups, highlighted by No. 10 NC State visiting No. 5 Clemson. Top-ranked Georgia visits Missouri, No. 2 Alabama visits No. 20 Arkansas, and No. 3 Ohio State hosts Rutgers.

Sportsbook Review is tracking the odds to win the CFP National Championship and Heisman Trophy all throughout the 2022 college football season. We also offer up our weekly power rankings and look at each week's most interesting odds and lines. Here, we track our college football experts' top picks on the biggest games each week.  

Click the links below to access our full college football picks previews for the biggest games on the Week 5 slate.

College Football Picks Week 5: Thursday

Utah State vs. BYU

Spread: BYU -24 (-107 via PointsBet)
Over/Under: Under 60 (-107 via PointsBet)
Prop: Utah State team total Under 17.5 (-135 via DraftKings Sportsbook)

College Football Picks Week 5 : Friday

Tulane vs. Houston

Spread: Houston -2.5 (-107 via PointsBet)
Over/Under: Over 54.5 (-105 via FanDuel Sportsbook)
Prop: First half Over 27 (-105 via DraftKings)

UTSA vs. Middle Tennessee

Spread: UTSA -4 (-110 via Caesars Sportsbook)
Over/Under: Under 63.5 (-110 via BetMGM)

San Diego State vs. Boise State

Spread: San Diego State +6.5 (-114 via FanDuel)
Over/Under: Under 39 (-110 via DraftKings)
Prop: San Diego State to win first half (+175 via DraftKings)

(15) Washington vs. UCLA

Spread: UCLA +3.5 (-114 via FanDuel)
Over/Under: Over 66 (-110 via DraftKings)
Prop: UCLA to score 40-plus points (+190 via PointsBet)

New Mexico vs. UNLV

College Football Picks Week 5: Saturday

(4) Michigan vs. Iowa

(7) Kentucky vs. (14) Ole Miss

Spread: Kentucky +6.5 (-107 via PointsBet)
Over/Under: Under 54.5 (-105 via FanDuel)
Prop: First half Under 27.5 (-108 via FanDuel)

(18) Oklahoma vs. TCU

Spread: TCU +6.5 (-107 via PointsBet)
Over/Under: Under 67.5 (+100 via PointsBet)
Prop: First half Under 32.5 (-105 via DraftKings)

Navy vs. Air Force

Oregon State vs. (12) Utah

Spread: Utah -10.5 (-105 via DraftKings)
Over/Under: Over 54.5 (-110 via FanDuel)
Prop: Utah first half spread -6.5 (-110 via DraftKings)

(2) Alabama vs. (20) Arkansas

Rutgers vs. (3) Ohio State

(9) Oklahoma State vs. (16) Baylor

Northwestern vs. (11) Penn State

(22) Wake Forest vs. (23) Florida State

Michigan State vs. Maryland

Virginia Tech vs. North Carolina

Spread: North Carolina -9 (-110 via DraftKings)
Over/Under: Under 51.5 (-110 via FanDuel)
Prop: First quarter Under 10.5 (-110 via DraftKings)

(17) Texas A&M vs. Mississippi State

LSU vs. Auburn

(1) Georgia vs. Missouri

(10) NC State vs. (5) Clemson

West Virginia vs. Texas

Spread: Texas -9 (-110 via DraftKings)
Over/Under: Under 62.5 (-110 via BetMGM)
Prop: First half Under 31.5 (-110 via FanDuel)

Indiana vs. Nebraska

Spread: Nebraska -5.5 (-110 via Caesars)
Over/Under: Under 60.5 (-110 via BetMGM)
Prop: Nebraska -3.5 first half spread (-105 via DraftKings)

Georgia Tech vs. (24) Pittsburgh

Colorado vs. Arizona

Spread: Arizona -17.5 (-107 via PointsBet)
Over/Under: Over 56.5 (-110 via FanDuel)
Prop: Arizona team total Over 37.5 (+100 via DraftKings)

Arizona State vs. (6) USC

Top Week 5 College Football Picks

Where to Bet on College Football

Here are our top-rated sportsbooks:

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