Uruguay vs. Spain Prediction: World Cup Picks & Best Bets (June 26)
The stakes are high heading into Friday's pivotal Group H meeting between Uruguay and Spain at Estadio Akron in Guadalajara, Mexico. My Uruguay vs. Spain prediction backs the 2024 European champion to live up to its billing as a -200 betting favorite with first place in Group H on the line.
My World Cup best bets also analyze why Mikel Oyarzabal is the likeliest scorer for Spain when the action gets going at 8 p.m. ET, airing on FOX, Telemundo, and FOX One.
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⚽ Uruguay vs. Spain predictions: Pick to win & player prop bets
See all of our experts' soccer picks across the best World Cup betting sites.
| 💰 Best bets | 📊 Best odds | ⚖️ Wager (units) |
|---|---|---|
| Spain ML | -200 via bet365 | 1.5u -> 0.75u |
| Both teams to score: No | -125 via bet365 | 1u -> 0.8u |
| Pedri anytime assist | +270 via FanDuel | 1u -> 2.7u |
| Under 2.5 goals | -111 via bet365 | 1u -> 0.9u |
⚽ Who will win Uruguay vs. Spain?
After a disappointing goalless draw against Cape Verde, Spain rebounded with a convincing 4-0 win over Saudi Arabia. The victory helped Spain secure a place in the Round of 32, but Luis de la Fuente’s side will have its sights set on another strong performance to seal first place in Group H.
Spain has a clear attacking advantage over Uruguay, while boasting a disciplined back line that hasn't conceded a goal in the first two games.
Meanwhile, Uruguay's World Cup campaign has been bitterly disappointing after draws against Saudi Arabia and Cape Verde. Uruguay's failure to win either of those games could lead to Marcelo Bielsa's men taking risks that might leave them exposed at the back.
Score prediction: Spain 2, Uruguay 0
💵 My best bet: Pedri anytime assist(+270)
This could be Pedri's breakout match. After a pair of solid performances to open the World Cup, we're backing Spain's creative spark to register his first goal contribution with an assist against Uruguay.
Pedri leads Spain with the most key passes, including five in a 0-0 draw against Cape Verde. He's among the leaders for passes completed in the final third at the 2026 World Cup. So, it's probably safe to say he's due for an assist.
🦶 Who will score in Uruguay vs. Spain?
Follow all of our expert soccer betting analysis for the 2026 World Cup.
Mikel Oyarzabal, F, Spain (+130)
Lamine Yamal is Spain's superstar, but Mikel Oyarzabal is the engine that keeps Spain's attack on track. Expect Oyarzabal to solidify his claim as Spain's go-to striker with another goal-scoring performance in Friday's meeting with Uruguay.
After recording two goals against Saudi Arabia, we're backing Oyarzabal's intelligent movement in the box to result in his third goal of the tournament. And with so many elite playmakers around him, Oyarzabal should have plenty of chances to add to his goal haul and join the Golden Boot conversation.
Best Uruguay vs. Spain goal-scorer pick: Mikel Oyarzabal (+130 via FanDuel)
🥅 Will both teams score in Uruguay vs. Spain?
Considering how solid Spain's defense has looked compared to Uruguay's inept attack, Both Teams to Score: No seems like a no-brainer.
Although Uruguay has to score to keep its World Cup campaign alive, the country has provided little reason to be optimistic that it can score against an elite defense like Spain's.
Both teams to score (BTTS) pick: No (-125 via bet365)
💡 How to bet on both teams to score (BTTS)
Our soccer expert Jeremy Vernon broke down how to bet BTTS at the World Cup with a full history and statistical analysis of the popular prop betting market across more than 7,000 matches.
📊 Uruguay vs. Spain odds
We're tracking the latest World Cup odds and favorites to win this year's tournament.
📺 How to watch Uruguay vs. Spain
- Date: Friday, June 26
- Kickoff: 8 p.m. ET
- Location: Estadio Akron (Guadalajara, Mexico)
- TV/Streaming: FOX, Telemundo, FOX One
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