Top Premier League Matchday 22 Betting Picks

Premier League leaders Manchester City can move 13 points clear of their closest rivals if they beat Chelsea this weekend. We look at that game and more with our Premier League Matchday 22 picks.

Man City are 10 points ahead of Chelsea at the top of the Premier League table thanks to 11 wins in a row. They take on the Blues this weekend in a game that will have huge ramifications for the title race. Elsewhere, Liverpool take on Brentford, while Spurs and Arsenal lock horns for the North London Derby.

Here are my top betting picks and predictions for the Premier League Matchday 22 schedule (odds via DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

Premier League Matchday 22 Picks

Man City to beat Chelsea and Under 4.5 goals (-105) ???West Ham to beat Leeds and Over 1.5 goals (-125) ????Tottenham vs. Arsenal - both teams to score & Over 2.5 goals (+110) ???

SEE ALSO: Top Ligue 1 Matchday 21 Betting Picks

Premier League Matchday 22 Predictions

Man City to win and Under 4.5 goals (-105)

City put in a brilliant performance to beat Chelsea 1-0 at Stamford Bridge earlier this season. That earned them a measure of revenge after suffering a surprise defeat to the Blues in last season's Champions League final.

Pep Guardiola's men have gone from strength to strength since then, and they're the overwhelming favorites to win a fourth Premier League title in five years. They have a few players missing for this game, including Riyad Mahrez, but City boast a deep squad and should put out a very strong starting 11.

City will also be fresher than Chelsea - who played in the EFL Cup against Spurs in midweek - and should extend their winning streak to 12 Premier League matches.

West Ham to win and Over 1.5 goals (-125)

The Hammers are back up to fifth in the table thanks to three wins in a row. Jarrod Bowen banged in a brace to lead them to a 2-0 victory against Norwich on Wednesday, so they should be full of confidence.

Leeds have endured a very poor season thus far. They've had rotten luck with injuries, as they're missing star midfielder Kalvin Phillips and several important defenders - striker Patrick Bamford could return in time for this game, but he's unlikely to be 100% fit. Their finishing has been wayward, too. Leeds have an expected goals tally of 24.25, but they've scored just 21 times.

West Ham have won all three Premier League games against Leeds since Marcelo Bielsa's men were promoted to the top flight, and they also beat Leeds 2-0 in the FA Cup last weekend. All four of those games went Over 1.5 goals.

Tottenham vs. Arsenal - both teams to score & Over 2.5 goals (+110)

Spurs are unbeaten in eight Premier League games since Antonio Conte replaced Nuno Espirito Santo as manager. However, they suffered some damaging defeats in other competitions and are coming off a loss to Chelsea in the EFL Cup.

Tottenham are great in attack, despite missing Son Heung-Min through injury, but weak in midfield and defense, and they're unlikely to keep a clean sheet against their fierce rivals this weekend.

Meanwhile, Arsenal have a midfield crisis with Thomas Partey away at the Africa Cup of Nations, and they've also looked shaky at the back in their last couple of games.

Both teams to score and Over 2.5 goals has paid off in the last two North London derbies, and it could land again this weekend.

Premier League Matchday 22 Quick Picks

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Premier League Matchday 22 picks made 1/13/2022 at 7:20 a.m. ET.