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Michail Antonio of West Ham celebrates the 4-2 goal during the English championship Premier League football match between Newcastle United and West Ham United on August 15, 2021 at St James Park in Newcastle, England - Photo Bruce White / Colorsport / DPPI (Photo by Bruce White / Colorsport / DPPI via AFP)

Premier League players will need to fight fatigue when they return to action for a midweek round of fixtures, and clubs with large squads could be well-positioned. Read on for our Premier League Matchday 14 picks.

Man City are now just one point behind Premier League leaders Chelsea after they battled to a 2-1 win over West Ham this past weekend. Liverpool are also right in the mix following their 4-0 victory over Southampton.

There are many more exciting midweek fixtures coming, including Everton against Liverpool and Manchester United facing Arsenal.

Here are my top betting picks and predictions for the Premier League Matchday 14 schedule (odds via DraftKings, and pick confidence is based on a one-to-five scale).

Premier League Matchday 14 Picks

Liverpool -1.25 Asian Handicap vs. Everton (-115) ???West Ham to beat Brighton (-110) ???Arsenal draw double chance vs. Manchester United (-110) ????

SEE ALSO: All Premier League Odds

Premier League Matchday 14 Predictions

Liverpool -1.25 Asian Handicap vs. Everton (-115)

Liverpool will vie for a third straight Premier League win when they lock horns with local rivals Everton during the Merseyside derby on Wednesday.

The Reds have earned back-to-back 4-0 triumphs against Arsenal and Southampton, and they're now only two points behind Chelsea.

Their recent record against Everton is underwhelming, but Liverpool has dominated this fixture during the Premier League era and should pick up a comfortable win.

Meanwhile, Everton are on a seven-game winless streak, and they've been sliding down the table to 14th. Star striker Dominic Calvert-Lewin is still injured, and the Toffees look toothless without him.

West Ham to beat Brighton (-110)

The Hammers will bid to stop a two-game skid when they host Brighton at the London Stadium this week.

David Moyes’ men lost 1-0 to Wolves on Nov. 29 and then fell 2-1 to Manchester City on Sunday.

Yet the club is still enjoying a very strong season while sitting fourth in the standings with seven wins after 13 games. Striker Michail Antonio has been in fine form, and the Hammers are deep enough to rotate on Wednesday.

On the other side, Brighton fans booed their team off the pitch after a 0-0 draw with Leeds on Saturday. The Seagulls have now gone eight games without a Premier League win. They've been resting for one more day than West Ham, but the Hammers possess more talent and should emerge victorious.

Arsenal draw double Chance vs. Manchester United (-110)

Arsenal are unbeaten over their last five games against Manchester United. That should give the players confidence as they prepare for Thursday.

The Gunners moved up to fifth in the table and five points clear of Manchester United after beating Newcastle 2-0 over the weekend. They've lost just once over their last 12 games, and that was against a dominant Liverpool squad.

Ralf Rangnick's arrival could galvanize Manchester United. He signed a deal to take over as interim manager until the end of the season.

However, his work permit may not be ready in time. And if he's in the dugout, Rangnick will not have been given long to work with the players.

Manchester United have logged just one win over their last eight Premier League games, and they're unlikely to beat Arsenal.

Premier League Matchday 14 Quick Picks

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SEE ALSO: All picks and odds. Be sure to check out SportsbookReview.com’s community forums and betting tools.

Premier League Matchday 14 Picks made on 11/29/21 at 10:11 a.m. ET.