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Manchester City's English midfielder #47 Phil Foden (C) celebrates with teammates as we make our best Manchester City vs. Real Madrid predictions for the second leg of their Champions League quarterfinal at the Etihad Stadium.
Manchester City's English midfielder #47 Phil Foden (C) celebrates with teammates after scoring his team's second goal during the UEFA Champions League quarter final first leg football match between Real Madrid CF and Manchester City at the Santiago Bernabeu stadium in Madrid on April 9, 2024. Photo by Pierre-Philippe MARCOU via AFP

The Champions League will see one of the favorites ousted on Wednesday, as Manchester City welcome Real Madrid to the Etihad Stadium for the return leg of their quarterfinal, and we have our expert prediction based on the best Champions League odds.

The Champions League quarterfinal clash between Real Madrid and Manchester City at the Bernabeu last week finished level at three, resembling the script from last season's semifinals. Everything hangs in the balance for Wednesday's second leg, which kicks off in Manchester at 3 p.m. ET. 

Manchester City are heavily favored (-310) to advance, boasting an impressive unbeaten record at the Etihad spanning 30 Champions League matches since 2018.

Real Madrid won't be daunted by their 4-0 defeat at the Etihad in last season's semifinals. They are La Liga's top away team, having lost just once in 16 away matches. Madrid, who have won all four away games in this season's competition, is unlikely to repeat their poor performance from their last visit to Manchester.

Along with our Bayern Munich vs. Arsenal prediction, here is our best Man City vs. Real Madrid prediction and soccer picks (odds via our best soccer betting sites; pick confidence based on a 1-to-5-star scale).

Man City vs. Real Madrid game info

  • Date: Wednesday, April 17, 3 p.m. ET
  • TV: CBS
  • Location: Etihad Stadium, Manchester, England
  • Weather: 48 degrees, sunny
  • Favorite: Manchester City (-150)

Man City vs. Real Madrid odds

(Odds via DraftKings)

TeamsMoneylineSpreadTotal
Manchester City-155-0.5 (-170)Over 2.5 (-175)
Real Madrid +400+0.5 (+125)Under 2.5 (+140)

Man City vs. Real Madrid prediction

Man City win + Over 2.5 goals ⭐⭐⭐⭐

While all sensational records eventually fall, Manchester City's 30-match unbeaten run at the Etihad in the Champions League should remain intact for at least one more game.

Pep Guardiola's side is fully fit and in no mood to let any team, including Real Madrid, get in its way of repeating as champion. It's not just City's home record in the competition that leaves jaws agape. They haven't lost at the Etihad in 28 Premier League matches, dating back to Nov. 12, 2022.

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City averages 2.53 goals per home contest in the Premier League and three in the Champions League. Their outrageous home unbeaten streak has one minor blemish, and it focuses on their defensive play. City kept a clean sheet in just four of the previous 14 Premier League matches and one of four in the Champions League, which will fill Carlo Ancelotti's side with belief.

City are on a 27-match unbeaten run in all competitions, while Real Madrid haven't had to deal with the sour taste of defeat in 14 contests, but something will have to give on Wednesday. If any team can pull off the upset, it's Madrid. Unfortunately, they have too many holes defensively to beat a team that can't recall what it feels like to lose on its home patch.

Best odds: +120 via DraftKings

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Man City vs. Real Madrid odds analysis

There are two similar markets that you might find as appealing. You can back a City win + Over 1.5 goals, offered by DraftKings at -120. It's a safer bet that would pay out $18.33 on a winning $10 bet. If you're feeling slightly braver, lock in Man City to win and both teams to score, which BetMGM offers at +190. That would pay out $29 on a $10 wager.

DraftKings' +120 on a City win and Over 2.5 goals implies a probability of 45.45%. A $10 winning bet pays out $22. The line might shorten slightly in the lead-up to kick-off but should remain relatively stable.

Manchester City vs. Real Madrid prediction made Monday at 1:37 p.m. ET.

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