Liverpool vs. Atletico Madrid Prediction: Expert Picks & Odds for Wednesday’s Champions League Match
The best time of the year has arrived as I turn my attention to the Champions League and offer my Liverpool vs. Atletico Madrid prediction for Wednesday’s tilt at Anfield, with kickoff set for 3 p.m. ET (Paramount+).
Liverpool are a -145 betting favorite, thanks to their historic dominance at home and against Spanish sides in the competition.
⚽ Liverpool vs. Atletico Madrid predictions & best bets
See our experts' soccer picks.
| 💰 Best bets | 📊 Best odds | ⚖️ Wager (units) |
|---|---|---|
| Liverpool and Over 2.5 goals | +130 via BetMGM | 1 unit to profit 1.3 units |
| Alexander Isak anytime goal | +138 via BetMGM | 0.5 units to profit 0.69 units |
| Alexander Isak to score & Liverpool to win | +200 via FanDuel | 0.25 units to profit 0.5 units |
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💰 Liverpool vs. Atletico Madrid best bet
Check out all of our soccer betting analysis and expert predictions this season.
Liverpool and Over 2.5 goals (+130)
Neither team has fulfilled expectations early in their domestic campaigns, but Liverpool usually finds a way to win at this stage of the Champions League at Anfield. The Reds won 17 of their previous 18 league-phase matches, and they will enter feeling good after securing their first victory of the season on the weekend against Ipswich Town.
Liverpool have also enjoyed success against Spanish sides recently, winning the previous six, including three against Atletico Madrid.
Atleti has allowed six second-half goals in four La Liga matches, and they will likely be without injured striker Alexander Sorloth.
🔥 More Liverpool vs. Atletico Madrid expert picks
Alexander Isak anytime goal (+138)
After a disappointing 2025-26 campaign in which Alexander Isak scored only three goals in 14 Premier League matches, this is the version of the primary talisman fans expected to see.
Isak bagged three goals in three matches, two of which occurred against Ipswich in Liverpool’s 2-0 win.
Isak looks to score for a third successive game in all competitions, and he will like his chances against a team that has conceded six second-half goals in four matches and put forth a putrid display in a recent 3-0 defeat to Athletic Bilbao.
⚖️ Liverpool vs. Atletico Madrid key stats
| Liverpool | Atletico Madrid | |
|---|---|---|
| Record (domestic) | 1-2-0 (Premier League) | 2-1-1 (La Liga) |
| Recent form (all comps) | DDW | WDWL |
| Goals for (domestic) | 6 | 7 |
| xG (domestic) | 5.41 | 5.8 |
| Goals against (domestic) | 4 | 6 |
| xGA (domestic) | 4.6 | 6.1 |
| Average possession (domestic) | 61.7% | 56.1% |
📊 Liverpool vs. Atletico Madrid odds
🆚 Liverpool vs. Atletico Madrid projected lineups
Here are the projected lineups for Liverpool vs. Atletico Madrid; subject to change:
| Liverpool (4-2-3-1) | Atletico Madrid (4-4-2) |
|---|---|
| Alisson (GK) | Oblak (GK) |
| Araujo (D) | Llorente (D) |
| Jacquet (D) | Pubill (D) |
| Van Dijk (D) | Romero (D) |
| Kerkez (D) | Grimaldo (M) |
| Szoboszlai (M) | Koke (M) |
| Gravenberch (M) | Hjulmand (M) |
| Barcola (M) | Simeone (M) |
| Wirtz (M) | Baena (M) |
| Gakpo (M/F) | Lookman (F) |
| Isak (F) | David (F) |
📺 How to watch Liverpool vs. Atletico Madrid
- Date: Wednesday, Sept. 9
- Kickoff: 3 p.m. ET
- Location: Anfield (Liverpool)
- TV/Streaming: Paramount+
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