NFL AI Predictions: Week 2 ATS Picks & Score Projections for Every Matchup
NFL Week 2 is here, and the latest NFL AI predictions feature against-the-spread picks and projected scores for all 16 games on the schedule.
The action begins Thursday night with the Detroit Lions visiting Josh Allen and the Buffalo Bills before a loaded Sunday slate. Week 2 concludes Monday night when the New York Giants visit the Los Angeles Rams at SoFi Stadium.
The ChatGPT AI model considers Week 1 performance, advanced metrics, roster and coaching changes, injuries, matchup advantages, and current market movement when projecting each game. All ATS picks below use Kalshi's NFL spread markets as of Thursday, Sept. 17.
Check out the complete 2026 NFL schedule and follow all of SBR's NFL picks throughout the season. Bettors can also compare the latest NFL odds before kickoff.
NFL AI predictions for Week 2
| Date | Kickoff (ET) | Prediction | ATS pick |
|---|---|---|---|
| Thu., Sept. 17 | 8:15 p.m. | Bills 34, Lions 24 | Bills -5.5 |
| Sun., Sept. 20 | 1 p.m. | Eagles 31, Titans 13 | Eagles -7.5 |
| Sun., Sept. 20 | 1 p.m. | Steelers 23, Patriots 20 | Steelers +5.5 |
| Sun., Sept. 20 | 1 p.m. | Bears 37, Vikings 24 | Bears -4.5 |
| Sun., Sept. 20 | 1 p.m. | Falcons 28, Panthers 24 | Falcons +2.5 |
| Sun., Sept. 20 | 1 p.m. | Jets 27, Packers 23 | Jets +3.5 |
| Sun., Sept. 20 | 1 p.m. | Ravens 38, Saints 24 | Ravens -8.5 |
| Sun., Sept. 20 | 1 p.m. | Bengals 31, Texans 27 | Bengals +2.5 |
| Sun., Sept. 20 | 1 p.m. | Buccaneers 34, Browns 17 | Buccaneers -8.5 |
| Sun., Sept. 20 | 4:05 p.m. | Jaguars 27, Broncos 23 | Jaguars +2.5 |
| Sun., Sept. 20 | 4:05 p.m. | Raiders 27, Chargers 24 | Raiders +6.5 |
| Sun., Sept. 20 | 4:25 p.m. | Cardinals 24, Seahawks 20 | Cardinals +3.5 |
| Sun., Sept. 20 | 4:25 p.m. | 49ers 38, Dolphins 17 | 49ers -13.5 |
| Sun., Sept. 20 | 4:25 p.m. | Commanders 30, Cowboys 24 | Commanders +4.5 |
| Sun., Sept. 20 | 8:20 p.m. | Chiefs 34, Colts 20 | Chiefs -6.5 |
| Mon., Sept. 21 | 8:15 p.m. | Rams 30, Giants 20 | Rams -7.5 |
Lions at Bills AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Lions | 7 | 7 | 3 | 7 | 24 |
| Bills | 7 | 10 | 10 | 7 | 34 |
Buffalo's offense picked up where it left off in a 36-31 victory over Houston, with Josh Allen accounting for four touchdowns and throwing for 334 yards. Detroit escaped New Orleans 31-30 in overtime but allowed Tyler Shough to throw for 410 yards. That's concerning ahead of a matchup with Allen, who once again sits atop SBR's NFL MVP odds. Detroit has enough offensive talent to stay competitive early, but Buffalo should create separation once Allen begins attacking that secondary.
ATS pick: Bills -5.5
Eagles at Titans AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Eagles | 7 | 10 | 7 | 7 | 31 |
| Titans | 3 | 3 | 0 | 7 | 13 |
Philadelphia wasn't dominant in its 24-22 win over Washington, but Jalen Hurts threw three touchdowns and the Eagles made the decisive plays late. Tennessee's opener was considerably more concerning, as the Titans produced just 10 points and 140 passing yards against the Jets. Philadelphia's advantage in the trenches should make it difficult for Tennessee to consistently sustain drives, while Saquon Barkley and Hurts can keep the Eagles balanced offensively. The matchup sets up well for Philadelphia to turn an early lead into a comfortable victory.
ATS pick: Eagles -7.5
Steelers at Patriots AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Steelers | 3 | 7 | 6 | 7 | 23 |
| Patriots | 3 | 7 | 3 | 7 | 20 |
New England's offense has an immediate problem after A.J. Brown landed on injured reserve, while Drake Maye threw three interceptions in the Patriots' 13-10 loss to Seattle. Pittsburgh's defense is particularly well-equipped to capitalize on those mistakes after T.J. Watt helped turn the Falcons over in a 20-13 Week 1 victory. New England deserves some respect at home, but laying more than a field goal against this Steelers defense looks aggressive. Pittsburgh can keep the score low and has a legitimate opportunity to win outright.
ATS pick: Steelers +5.5
Vikings at Bears AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Vikings | 7 | 7 | 3 | 7 | 24 |
| Bears | 10 | 10 | 10 | 7 | 37 |
Chicago couldn't have made a louder offensive statement in Week 1, producing 552 total yards and 59 points against Carolina. Minnesota was impressive in its own right, scoring 29 unanswered points in a 39-22 win over Green Bay, but Kyler Murray's concussion makes his status a major factor entering Sunday. Carson Wentz played well in relief, but Chicago's offense presents a much different challenge on the road. Caleb Williams and D'Andre Swift should keep the Bears moving, with Chicago eventually creating a two-score cushion.
ATS pick: Bears -4.5
Panthers at Falcons AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Panthers | 7 | 7 | 3 | 7 | 24 |
| Falcons | 7 | 10 | 3 | 8 | 28 |
Carolina scored 37 points in Week 1, but allowing a franchise-record 59 to Chicago while committing three turnovers makes the Panthers difficult to trust as road favorites. Atlanta's offense wasn't much better in a 20-13 loss to Pittsburgh, but this represents a far more favorable matchup for the Falcons. Carolina's defensive issues should give Atlanta opportunities to establish the run and avoid obvious passing situations. Kalshi has flipped the Panthers into slight favorites, creating value on Atlanta getting points at home.
ATS pick: Falcons +2.5
Packers at Jets AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Packers | 3 | 7 | 6 | 7 | 23 |
| Jets | 7 | 7 | 6 | 7 | 27 |
Green Bay's Week 1 collapse raises some immediate concerns. Jordan Love threw for 387 yards, but the Packers surrendered 29 unanswered points and committed two costly late turnovers in a 39-22 loss to Minnesota. New York played a much cleaner game, controlling possession for nearly 39 minutes while Breece Hall rushed for 102 yards in a 23-10 win over Tennessee. The Packers have the more explosive passing offense, but getting more than a field goal with a Jets team capable of controlling the pace looks attractive.
ATS pick: Jets +3.5
Saints at Ravens AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Saints | 7 | 7 | 3 | 7 | 24 |
| Ravens | 10 | 14 | 7 | 7 | 38 |
New Orleans showed far more offensive upside than expected in Week 1, with Tyler Shough throwing for 410 yards and three touchdowns in an overtime loss to Detroit. Baltimore presents a much more difficult challenge. The Ravens scored 41 points at Indianapolis while Derrick Henry rushed for 144 yards and three touchdowns, allowing Lamar Jackson to play from advantageous situations throughout the afternoon. New Orleans can score enough to keep this interesting early, but Baltimore's rushing attack and defensive pressure should create significant separation after halftime.
ATS pick: Ravens -8.5
Bengals at Texans AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Bengals | 7 | 10 | 7 | 7 | 31 |
| Texans | 7 | 7 | 6 | 7 | 27 |
Cincinnati's rebuilt defense made an immediate impact against Tampa Bay, forcing four turnovers and recording four sacks in a 33-27 victory. Houston generated 381 yards against Buffalo but repeatedly hurt itself, with C.J. Stroud losing two fumbles in a 36-31 defeat. The Texans deserve respect at home, yet Cincinnati getting points is appealing, with Joe Burrow, Ja'Marr Chase, and Tee Higgins capable of exploiting a Houston defense that just surrendered 36. If the Bengals avoid Tampa Bay's turnover problems from a week ago, they can win this outright.
ATS pick: Bengals +2.5
Browns at Buccaneers AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Browns | 3 | 7 | 0 | 7 | 17 |
| Buccaneers | 7 | 10 | 10 | 7 | 34 |
Tampa Bay committed four turnovers against Cincinnati and still managed to score 27 points, which speaks to the offense's upside entering a much softer matchup. Cleveland was overwhelmed 34-10 by Jacksonville, with Deshaun Watson taking five sacks and the Browns converting only one of eight third downs. Baker Mayfield also gets a matchup against his former franchise, adding another storyline to Sunday's game. If Tampa simply takes better care of the football, its offense should be able to build a comfortable multi-score advantage.
ATS pick: Buccaneers -8.5
Jaguars at Broncos AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Jaguars | 7 | 10 | 3 | 7 | 27 |
| Broncos | 7 | 7 | 3 | 6 | 23 |
Jacksonville couldn't have asked for a much better opener, beating Cleveland 34-10 behind four touchdown passes from Trevor Lawrence and a turnover-free offensive performance. Denver still has its Week 1 matchup with Kansas City to play on Monday night, meaning the Broncos will also have one fewer day to prepare. Mile High gives Denver a legitimate home-field edge, but Jacksonville getting points after such an efficient opening performance is appealing. The Jaguars have enough offensive balance and defensive pressure to turn this into another outright upset opportunity.
ATS pick: Jaguars +2.5
Raiders at Chargers AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Raiders | 7 | 10 | 3 | 7 | 27 |
| Chargers | 7 | 7 | 3 | 7 | 24 |
Las Vegas looked considerably sharper than Los Angeles in Week 1. Kirk Cousins threw three touchdown passes in a 27-13 win over Miami, while Ashton Jeanty produced 147 yards from scrimmage. The Chargers were held to 14 points by Arizona, with Justin Herbert throwing for only 209 yards. Los Angeles has too much offensive talent to write off after one poor performance, but asking the Chargers to cover nearly a touchdown against a divisional opponent is difficult. The Raiders have enough firepower to stay close and potentially win outright.
ATS pick: Raiders +6.5
Seahawks at Cardinals AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Seahawks | 3 | 7 | 3 | 7 | 20 |
| Cardinals | 7 | 7 | 3 | 7 | 24 |
Seattle's defense carried it to a 13-10 Week 1 win over New England, but the offense was far from convincing with Drew Lock starting in place of the injured Sam Darnold. Arizona, meanwhile, opened the Mike LaFleur era with an impressive 26-14 road victory over the Chargers as Jacoby Brissett threw for 277 yards. Seattle's defense keeps its floor relatively high, but laying more than a field goal on the road with questions at quarterback is difficult. Arizona has a realistic chance to win this NFC West matchup outright.
ATS pick: Cardinals +3.5
Dolphins at 49ers AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Dolphins | 3 | 7 | 0 | 7 | 17 |
| 49ers | 10 | 14 | 7 | 7 | 38 |
San Francisco produced one of Week 1's biggest statements, beating the Rams 27-7 in Melbourne behind three Brock Purdy touchdown passes. Miami's new-look offense managed only 13 points against Las Vegas, and Malik Willis completed just 15 of his 27 attempts with an interception. The spread is enormous, but the matchup supports it. San Francisco can pressure Miami into obvious passing situations while leaning on its own rushing attack once it gets ahead. This is one of Week 2's clearest candidates for a genuine blowout.
ATS pick: 49ers -13.5
Commanders at Cowboys AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Commanders | 7 | 10 | 6 | 7 | 30 |
| Cowboys | 7 | 7 | 3 | 7 | 24 |
Washington nearly erased a double-digit deficit against Philadelphia before falling 24-22, with Jayden Daniels leading two fourth-quarter touchdown drives. Dallas had a rougher opener, allowing 394 total yards and 165 on the ground in a 28-20 loss to the Giants. The Cowboys still possess plenty of offensive talent, but their defensive performance makes laying more than a field goal difficult in a divisional matchup. Washington's mobility at quarterback and ability to run the football should cause problems, giving the Commanders a real chance to win outright.
ATS pick: Commanders +4.5
Colts at Chiefs AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Colts | 3 | 7 | 3 | 7 | 20 |
| Chiefs | 10 | 10 | 7 | 7 | 34 |
Indianapolis' defense struggled badly against Baltimore, allowing 41 points while Lamar Jackson threw for 324 yards and Derrick Henry scored three rushing touchdowns. That's a concerning setup before a trip to Arrowhead Stadium. Patrick Mahomes gives Kansas City another quarterback who can exploit the Colts' issues defending explosive plays, and the Chiefs should also be able to create pressure on Daniel Jones. Kansas City's Week 1 game against Denver still has to be played, but assuming the Chiefs emerge healthy, this matchup has the potential to become lopsided.
ATS pick: Chiefs -6.5
Giants at Rams AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Giants | 3 | 7 | 3 | 7 | 20 |
| Rams | 7 | 10 | 6 | 7 | 30 |
New York made an impressive start to the John Harbaugh era, beating Dallas 28-20 as Jaxson Dart completed 23 of 29 passes for 230 yards and three touchdowns. Los Angeles had the opposite experience, scoring only seven points in a 27-7 loss to San Francisco. The Rams still have enough top-end talent to respond at SoFi Stadium, and Matthew Stafford should have a more manageable matchup than he faced against the 49ers. New York can stay competitive early, but Los Angeles has the stronger path to pulling away after halftime.
ATS pick: Rams -7.5
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