Lions vs. Bills Touchdown Pick: Best TD Scorer Prediction for TNF (Sept. 17)

The Detroit Lions and Buffalo Bills meet Thursday night in a Week 2 matchup on Thursday Night Football. Kickoff is set for 8:15 p.m. ET at Highmark Stadium in Orchard Park, New York, with the game airing on Prime Video. Our top Lions vs. Bills touchdown scorer pick is wide receiver DJ Moore.

Moore enters the matchup after an impressive Bills debut, recording five catches for 100 yards and a touchdown against Houston. His big-play ability and role as a key piece of Buffalo's passing attack make him our favorite anytime touchdown candidate Thursday night.

🏈 Lions vs. Bills touchdown scorer prediction: Thursday Night Football

Check out all of our NFL picks for more analysis across this week's slate.

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💰 Lions vs. Bills best touchdown bet

DJ Moore is my anytime touchdown pick against the Lions on Thursday night. The veteran wide receiver brings explosive playmaking ability and should remain a major part of Buffalo’s passing attack. Moore’s ability to create separation and make plays after the catch gives him multiple ways to reach the end zone.

With Buffalo expected to rely on its passing game against Detroit, Moore should see plenty of opportunities, particularly in the red zone. His combination of speed, route-running and big-play ability makes him a dangerous scoring threat. If Buffalo moves the ball consistently, Moore has an excellent opportunity to find paydirt.

📊 Lions vs. Bills: Thursday Night Football

🚑 Lions vs. Bills latest injuries

📺 How to watch Lions vs. Bills: Thursday Night Football

• Date: Thursday, Sept. 17
• Kickoff: 8:15 p.m. ET
• Location: Highmark Stadium (Orchard Park, NY)
• TV: Prime Video