NFL Moneyline Picks for Week 4: Best Bets to Win Every Game
Last Updated: September 29, 2026 12:56 PM EDT • 3 minute read X Social Google News Link
We’re already in Week 4 of the 2026 season, and I'm sharing my NFL moneyline picks for every game.
This will help form the basis of my against-the-spread picks, which go live tomorrow. Let’s dive into which team to back for every tilt, including three feature matchups. The feature matches were chosen with several criteria in mind, including prospective winners with the most palatable odds.
NFL moneyline picks: Week 4
See all of our experts' NFL picks for Week 4 based on the latest NFL odds.
| Matchup | Pick | Confidence |
|---|---|---|
| Titans vs. Ravens | Ravens (-770) | ⭐⭐⭐⭐⭐ |
| Lions vs. Panthers | Lions (-188) | ⭐⭐⭐⭐⭐ |
| Patriots vs. Bills | Bills (-320) | ⭐⭐⭐⭐⭐ |
| Dolphins vs. Vikings | Vikings (-650) | ⭐⭐⭐⭐⭐ |
| Jets vs. Bears | Bears (-190) | ⭐⭐⭐⭐ |
| Packers vs. Buccaneers | Packers (-194) | ⭐⭐⭐⭐ |
| Rams vs. Eagles | Rams (-162) | ⭐⭐⭐⭐ |
| Cowboys vs. Texans | Texans (-134) | ⭐⭐⭐⭐ |
| Chargers vs. Seahawks | Seahawks (-350) | ⭐⭐⭐⭐ |
| Chiefs vs. Raiders | Chiefs (-230) | ⭐⭐⭐⭐ |
| Steelers vs. Browns | Steelers (-142) | ⭐⭐⭐⭐ |
| Colts vs. Commanders | Commanders (+166) | ⭐⭐⭐ |
| Jaguars vs. Bengals | Bengals (-132) | ⭐⭐⭐ |
| Cardinals vs. Giants | Cardinals (-110) | ⭐⭐⭐ |
| Broncos vs. 49ers | Broncos (+120) | ⭐⭐⭐ |
| Falcons vs. Saints | Falcons (+126) | ⭐⭐⭐ |
💡 More Week 4 predictions
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 4.
My best NFL Week 4 moneyline bets
🏗️ Steelers (-142) vs. Browns ⭐⭐⭐⭐
Despite the rash of injuries to the Pittsburgh Steelers’ secondary, this matchup is tailor-made for Mike McCarthy and Co. to snatch an ugly win.
After two dreadful offensive performances, the Steelers were much better in their upset of the Cincinnati Bengals, thanks to a rejigged offensive line.
The changes led to an immediate all-around improvement. The running game improved from 3.4 to 6 yards per carry, and Rodgers was sacked only twice after going down four times the previous week.
Meanwhile, the Browns - lucky to escape with a comeback victory over the Carolina Panthers - are not as good as their 2-1 record indicates.
🧀 Packers (-194) vs. Buccaneers ⭐⭐⭐⭐
Considering how poorly the Packers have played, their -194 odds and 65.99% implied win probability provide reasons to pause. However, they face a team that set a record in the Week 3 loss to the Vikings for the most straight ATS defeats (12).
They will also be without the injured Baker Mayfield, with undrafted Jalon Daniels set to make his first NFL start. Before the 2024 season, rookies in their first start had a 16-35-1 record. While the Packers offensive line has been woeful, it faces a Buccaneers defense that blitzes at the third-highest rate. Despite their propensity to blitz, Todd Bowles’ defense ranks in the lower half of hurry percentage, QB knockdown percentage, and pressure percentage.
🌵Cardinals (-110) vs. Giants ⭐⭐⭐
I’m featuring this pick because of the much more palatable -110 odds. The Cardinals rarely win, picking up four victories in the previous 20 games.
However, they have a relatively cohesive and productive offense, which is more than I can say for the New York Giants under Jameis Winston's stewardship.
As it happens, the current scenario might be fleeting after the team landed J.J. McCarthy from the Minnesota Vikings. Most signs, however, point to Winston getting the nod in Week 4.
The whimsical 32-year-old has been putrid since replacing the injured Jaxson Dart, leading the team to 18 measly points. The Cardinals put up 30 against a banged-up San Francisco 49ers defensive line and 26 in the opening win over the Los Angeles Chargers.
I’ll take that over the most predictable, inefficient offense.
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Gary Pearson X social