Dolphins vs. 49ers Prediction: Week 2 Odds, Picks & Best Bet
My Dolphins vs. 49ers prediction explores Miami's difficult task in Week 2 as the biggest underdog of the slate.
Kickoff is at 4:25 p.m. ET from Levi's Stadium in Santa Clara, Calif. (FOX), with the 49ers priced as a 12.5 to 13.5-point home betting favorite.
🏈 Dolphins vs. 49ers picks & predictions
See all of our experts' NFL picks for Week 2 based on the latest NFL odds.
| Pick | Bet size |
|---|---|
| 49ers -12.5 (-120 via FanDuel) | 1 unit |
| Over 45.5 (-108 via FanDuel) | 0.5 units |
Total wagered: 1.5 units | Max profit: 1.29 units
💰 Dolphins vs. 49ers prediction & best bet
49ers -12.5 (-120 via FanDuel)
We all knew this was going to be a difficult season for the Dolphins, and a cross-country trip to San Francisco is one of the worst situations imaginable for this barren Miami roster.
Even if the 49ers are fatigued by the trip home from Melbourne, the talent disparity is too significant to forecast anything other than a blowout victory for San Fran here.
That imbalance will be most evident on the line of scrimmage. The Raiders sacked Malik Willis five times last week and held De'Von Achane to 36 rushing yards. Now imagine what the Nick Bosa-led unit can do.
FanDuel is the only one of our best sports betting sites still offering a 12.5-point spread. I don't mind paying up slightly to get that number over the 13.5 available at other major sportsbooks. But if 49ers -13.5 is all you can get, bet it with confidence.
📡 SBR Edge
Only the Falcons and Broncos had a worse offensive EPA/play than the Dolphins in Week 1.
New 2-headed monster in 49ers' backfield?
Christian McCaffrey averaged nearly seven yards per carry against the Rams but stayed fresh because of limited usage. Rookie Kaelon Black led the team in Week 1 carries and was one of four 49ers to have a 10-plus-yard rush, alongside McCaffrey, Deebo Samuel, and Brock Purdy.
That deeper rushing attack should help CMC stay fresh in the long term and provide the 49ers with the bodies to hammer the Dolphins' defensive front throughout this Sunday's contest.
Score prediction: 49ers 34, Dolphins 17
📊 Dolphins vs. 49ers odds
See the latest NFL odds for every Week 2 matchup.
Dolphins vs. 49ers opening odds
- Moneyline: Dolphins +570 | 49ers -909
- Spread: Dolphins +12.5 (-110) | 49ers -12.5 (-110)
- Over/Under: Over 46.5 (-110) | Under 46.5 (-110)
📺 How to watch Dolphins vs. 49ers: Week 2
- Date: Sunday, Sept. 20
- Kickoff: 4:25 p.m. ET
- Location: Levi's Stadium (Santa Clara, Calif.)
- TV: FOX
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