Colts vs. Chiefs Prediction: Week 2 Odds, Picks & Best Bet
Teams whose Week 1 performances couldn’t have been more contrasting clash at GEHA Field at Arrowhead Stadium for Sunday Night Football (8:20 p.m. ET, NBC), and I’m backing Patrick Mahomes and Co. to cover the spread in my Colts vs. Chiefs prediction.
The Chiefs are the 6.5-point betting favorite for the prime-time clash. The analysis below is part of our Week 2 predictions.
🏈 Colts vs. Chiefs picks & predictions
See all of our experts' NFL picks for Week 2 based on the latest NFL odds.
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💰 Colts vs. Chiefs prediction & best bet
Chiefs -6.5 (-115 via BetMGM)
Kenneth Walker III set a career rushing-yards mark (173) in his debut with the Chiefs. Walker's importance to the Chiefs offense can't be overstated, as he lets Mahomes and Co. execute under center more effectively while disguising passes through play action.
The Chiefs racked up 31 points against the Denver Broncos despite Mahomes completing only 15 passes for 184 yards.
The Chiefs’ newfound versatility should petrify an Indianapolis Colts team that allowed 41 points, including 304 passing yards and 202 rushing yards against the Baltimore Ravens in Week 1.
📡 SBR EDGE - Chiefs ground attack vs. Colts rushing D
The Colts allowed 202 yards and 5.5 yards per carry against the Ravens in Week 1, while Walker averaged 7.5 yards per carry against the Broncos.
Daniel Jones will feel the heat
Daniel Jones didn't look comfortable in his first game back after tearing his Achilles tendon last season. He had the 27th-ranked QB rating (72.8) via Pro Football Focus, with just 166 passing yards on 19 completions and 31 attempts.
Steve Spagnuolo’s defense tied for the seventh-highest blitz percentage in Week 1 (33.3%), and I expect the Chiefs to bring the heat again. I’m not confident in Jones’ mobility or his ability to solve problems quickly enough.
Score prediction: Chiefs 31, Colts 20
📊 Colts vs. Chiefs odds
See the latest NFL odds for every Week 2 matchup.
Colts vs. Chiefs opening odds
- Moneyline: Colts +240 | Chiefs -295
- Spread: Colts +6.5 (-110) | Chiefs -6.5 (-108)
- Over/Under: Over 48 (-112) | Under 48 (-105)
📺 How to watch Colts vs. Chiefs: Week 2
- Date: Sunday, Sept. 20
- Kickoff: 8:20 p.m. ET
- Location: GEHA Field at Arrowhead Stadium
- TV: NBC
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