Colts vs. Steelers Prediction: Week 5 Odds, Picks & Best Bet
Indianapolis looks to win its third game in a row after an 0-2 start as I provide my Colts vs. Steelers prediction.
Today's matchup kicks off at 1 p.m. ET from Acrisure Stadium in Pittsburgh (CBS), with the Steelers priced as a 2.5-point home betting favorite.
🏈 Colts vs. Steelers picks & predictions
See all of our experts' NFL picks for Week 5 based on the latest NFL odds.
| Pick | Bet size |
|---|---|
| Colts ML (+124 via DraftKings) | 0.5 units |
| Under 44.5 (-108 via DraftKings) | 1 unit |
Total wagered: 1.5 units | Max profit: +1.55 units
Colts vs. Steelers prediction & best bet
Under 44.5 (-108 via DraftKings)
Expect a low-scoring AFC slugfest in Pittsburgh because of the two impotent passing games involved here.
Aaron Rodgers and Daniel Jones have been two of the worst quarterbacks in the league, especially if you pop the hood on their underlying analytics. Only Baker Mayfield ranks worse in EPA/play than Rodgers and Jones among QBs with at least 100 snaps this season.
I bet Under 44.5 for Colts vs. Steelers, but there's still value in taking the Under all the way down at a 42.5-point total.
📡 SBR Edge: Pittsburgh's struggles against the run
The Steelers have been out-rushed in three of four games, even before facing Pro Bowl RB Jonathan Taylor.
Rodgers can no longer handle pass-rush pressure
No QB has been sacked more than Aaron Rodgers in 2026. Meanwhile, Indy's defense has at least two sacks in every game this season while allowing an average of just 15 points over the last two weeks.
That's an advantage the Colts can exploit en route to a road win on Sunday.
Score prediction: Colts 22, Steelers 19
Live Colts vs. Steelers odds
Colts vs. Steelers opening odds
- Moneyline: Colts +114 | Steelers -140
- Spread: Colts +2.5 (-110) | Steelers -2.5 (-110)
- Over/Under: Over 44.5 (-110) | Under 44.5 (-110)
How to watch Colts vs. Steelers: Week 5
- Date: Sunday, Oct. 11
- Kickoff: 1 p.m. ET
- Location: Acrisure Stadium (Pittsburgh)
- TV: CBS
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