Colts vs. Commanders Prediction: Week 4 Odds, Picks & Best Bet

Our Colts vs. Commanders prediction for Week 4 includes our best bet, projected score, and the latest odds for Sunday's matchup.
Pictured: Quarterback Marcus Mariota throwing a pass as we break down our Colts vs. Commanders Prediction. Photo by Geoff Burke-Imagn Images.
Pictured: Quarterback Marcus Mariota throwing a pass as we break down our Colts vs. Commanders Prediction. Photo by Geoff Burke-Imagn Images.
Enjoying SBR content? Add us as a preferred source on your Google account Add as a preferred source on Google

Anyone fancy drinking a cup of tea to commemorate Sunday’s 9:30 a.m. ET London encounter (NFL Network) featuring two of the worst-scoring defenses? 

I’m counting on more leaky defense at Tottenham Hotspur Stadium, which my Colts vs. Commanders prediction reflects. With Marcus Mariota looking to pull off a second straight upset, the Commanders are the 4-point betting underdog. The analysis below is part of our Week 4 NFL predictions.


🏈 Colts vs. Commanders picks & predictions

See all of our experts' NFL picks for Week 3 based on the latest NFL odds.

Pick Bet size
Commanders +4 (-112 via BetMGM) 0.89 unit
Over 48.5 (-108 via FanDuel) 1 unit

Total wagered: 2 units | Max profit: +1.82 units


💰 Colts vs. Commanders prediction & best bet

Over 48.5 (-108 via FanDuel)

Sunday’s London matchup features teams that have allowed the second-most (Commanders) and third-most (Colts) points per game. 

Neither defense is good at defending aerial attacks either, with the Commanders sporting the 29th-worst defensive pass DVOA and the Colts 28th-worst. With the second-best EPA per play, the Colts have been proficient on the ground. 

However, the Commanders are the best against the run in DVOA. That should facilitate a pass-heavy game script. 

Despite throwing an interception in each game, Daniel Jones is showing signs of being more comfortable with every outing. And Mariota exploded in his first start, leading the Commanders to a 33-point outburst against the Super Bowl champs.

📡 SBR Edge: Washington's defensive struggles

The Commanders have allowed at least 27 points in 12 of the previous 20 games dating back to the start of last season

Commanders' defensive dichotomy

Through three weeks, the Commanders are one of five teams that have not allowed a rushing TD. Conversely, they have allowed the most passing TDs (11). The Commanders have also allowed seven more fantasy points per reception to opposing wide receivers than any other team.

Score prediction: Colts 27, Commanders 24


📊 Live Colts vs. Commanders odds

See the latest NFL odds for every Week 4 matchup.


Colts vs. Commanders opening odds

  • Moneyline: Colts -105 | Commanders -115
  • Spread: Colts +1.5 (-120) | Commanders -1.5 (+100)
  • Over/Under: Over 49.5 (-110) | Under 49.5 (-110)

📺 How to watch Colts vs. Commanders: Week 4

  • Date: Sunday, Oct. 4
  • Kickoff: 9:30 a.m. ET
  • Location: Tottenham Hotspur Stadium (London)
  • TV: NFL Network

📃 Affiliate disclosure

Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)