Miami vs. Clemson Prediction: Week 5 Odds, Picks & Best Bet

Our Miami vs. Clemson prediction for Week 5 includes our best bet, projected score, and the latest odds for Saturday's matchup.
Clemson quarterback Tait Reynolds (2) passes as he is featured in our Miami vs. Clemson prediction.
Pictured: Clemson quarterback Tait Reynolds (2) passes as he is featured in our Miami vs. Clemson prediction. Photo by Ken Ruinard / USA Today Network / USA TODAY NETWORK via Imagn Images
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Darian Mensah's ridiculous passing efficiency will be tested during his second road game of the season in my latest Miami vs. Clemson prediction. No. 4 Miami has benefited from Mensah's transfer, as he boasts an 88.7 percent completion rate with 14 touchdowns and 0 interceptions for the Hurricanes.

Oddsmakers have Miami valued as a -16.5-point betting favorite on the road at Memorial Stadium in Clemson, S.C., leading up to Saturday's opening kickoff at 7:30 p.m. ET (ABC). 


🏈 Miami vs. Clemson picks & predictions

See all of our experts' college football picks for Week 5 based on the latest college football odds.

Pick Bet size
Clemson +16.5(-105 via DraftKings) 2.10 units to win 2.00 units
Under 47.5 (-102 via DraftKings) 2.04 units to win 2.00 units

Total wagered: 4.14 units | Max profit: 4.00 units

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💰 Miami vs. Clemson prediction & best bet

Check out all of our college football predictions for more analysis across this week's slate.

Clemson +16.5 (-105 via DraftKings)

The chance to bet Clemson +17.5 is no longer available. However, steam is moving toward the Tigers, who find themselves 2.5 touchdown underdogs at home this weekend. 

Dabo Swinney's group took advantage of a 2.5-hour delay against North Carolina during QB Tait Reynolds first start. He led the Tigers to a clutch 4th-quarter rally to avoid an upset by the Tar Heels. 

Then, Clemson went on the road and posted a solid 24-10 win over California in Week 4, limiting the Golden Bears' offense to 231 total yards. 

Clemson's defense has forced 5 turnovers during its 3-game winning streak, while averaging 5.3 YPC against UNC and Cal. Miami's defense gave up 312 passing yards and 3 touchdowns to Wake Forest during a 33-20 win in Week 3.  

This game comes down to Clemson's defense limiting Mensah's red-hot efficiency from the pocket. +16.5 feels like too many points for a Clemson team rallying around a new quarterback after a bad Week 1 loss to LSU. 

Let's play the contrarian side of the spread, with 72 percent of public bets on Miami -16.5, and take Clemson +16.5 at -105 odds on DraftKings. 

📡 SBR Edge: Halloween Home Cookin'

Clemson has won 23 of its previous 24 home games played in October. 

Tigers' Defense Limits Mensah's Hurricanes

While Clemson is still finding its identity on offense, the strength of this roster is on its defense. The Tigers have limited opponents to 3 total touchdowns in their last 3 matchups, while holding UNC and Cal to under 150 passing yards. 

Mensah's passing numbers are due for regression. Clemson's the likely candidate, as the Tigers have held 3 straight teams to a 56 percent completion rate or worse. Miami wins but fails to cover in a low-scoring grinder of a game. 

Score prediction: Miami 30, Clemson 17


📊 Miami vs. Clemson odds

See the latest college football odds for every Week 5 matchup.

Miami vs. Clemson opening odds

  • Moneyline: Miami -880 | Clemson +600
  • Spread: Miami -17.5 (-108) | Clemson +17.5 (-112)
  • Over/Under: Over 50.5 (+100) | Under 50.5 (-120)

📺 How to watch Miami vs. Clemson: Week 5

  • Date: Saturday, Oct. 3
  • Kickoff: 7:30 p.m. ET
  • Location: Memorial Stadium (Clemson, S.C.)
  • TV: ABC

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Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)